Nephrology In the Department of Medicine

Ralph Rabkin, MD

Professor of Medicine, Emeritus

Ralph Rabkin, MD

Office Address

Nephrology
3801 Miranda Ave 154L MC: 111R
154L MC: 111R
Palo Alto , CA 94305
(650) 858-3985

Professional Education

Residency

Years on Staff

27

Research Interests

Advanced chronic renal failure (CRF) is often complicated by muscle wasting and malnutrition, conditions that adversely affect morbidity and mortality Many factors contribute to the wasted state including acquired resistance to anabolic hormones such as growth hormone (GH) and insulin-like growth factor-1, that are required for normal body and muscle growth. Apart from its impact in uremia, GH resistance has also been implicated as a cause of muscle wasting in a wide range of conditions including CHF, hepatic failure, chronic inflammatory diseases and sepsis. In children with renal failure GH resistance leads to impaired body growth. To some extent uremic GH resistance can be overcome by high doses of GH. In uremic children GH treatment increases body growth and muscle mass and in adults GH has significant anabolic effects and increases lean body mass. Dr Rabkins research is directed at elucidating the pathomechanisms causing the resistance to GH. In particular he is interested in unraveling the defects in GH mediated signal transduction that occurr in uremia. To this end experiments are carried out with cells in culture, rat models of chronic renal failure and finally based on the outcome of these basic experiments, human subjects with advanced renal failure are studied. Dr Rabkin is also engaged in studying the role of growth hormone and insulin-like growth factor-1 in animal models of diabetic nephropathy.

Publications

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