Nephrology In the Department of Medicine

Timothy W. Meyer, MD

Professor of Medicine
Chief, Division of Nephrology

Timothy W. Meyer, MD

Research Interests

Progression of Renal Disease

A number of factors contribute to progressive nephron loss once the kidney is damaged by disease. These factors include increases in glomerular capillary pressure and glomerular volume, alterations in glomerular epithelial cell structure, and tubular atrophy. Current research efforts are directed toward discovering the mechanisms responsible for these changes, and testing new drug therapies designed to retard the progression of experimental renal disease. Animal studies involve measurement of renal function, administration of experimental drugs, and evaluation of glomerular structure by morphometry. Clinical studies involve follow-up measurements of kidney function and structure in patients with chronic renal insufficiency.

Uremic Toxicity

The nature of the toxic chemicals that build up in patients without kidneys is surprisingly little understood. Without better knowledge of these chemicals, it is hard to improve renal replacement therapy. Current research efforts are directed toward identifying protein-bound small molecules which accumulate in uremia. The clearance of these molecules during dialysis, CVVH, and CVVHDF is then modeled and measured. Clinical studies involve testing the ability of different renal replacement prescriptions to improve clearances of the molecules of interest.

Publications

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