Selected Publications

To view the articles which are indicated as Portable Document Format () files, download a free Acrobat Reader from Adobe

  • Han F, Faraco J, Dong XS, Ollila HM, Lin L, et al. (2013) Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic. PLoS Genet 9(10): e1003880. doi:10.1371/journal.pgen.1003880. Article ()
  • Faraco J, Lin L, Kornum BK, Kenny EE, Trynka G,  Einen M, Rico TJ, Lichtner P, Dauvilliers Y, Arnulf I, Lecendreux M, Javidi S, Geisler P, Mayer G, Pizza F, Poli F, Plazzi G, Overeem S Lammers GJ,  Kemlink D, Sonka K, Nevsimalova S, Rouleau G, Desautels A, Montplaisir J, Frauscher B, Ehrmann L, Högl B, Jennum P, Bourgin P, Peraita-Adrados R, Iranzo A, Bassetti C, Chen WM, Concannon P, Thompson SD, Damotte V, Fontain B, Breban M, Gieger C, Klopp N, Deloukas P, Wijmenga C, Hallmayer J, Onengut-Gumuscu S, Rich SS, Winkelmann J, Mignot E. ImmunoChip study implicates antigen presentation to T cells in narcolepsy. Plos Genetics, 2013;9(2):e1003270. doi: 10.1371/journal.pgen.1003270. Epub 2013 Feb 14. Article ()
  • Andlauer O, Moore H, Jouhier L, Drake C, Peppard PE, Han F, Hong SH, Poli F, Plazzi G O’Hara R, Haffen E, Roth T, Young T, Mignot E.  Nocturnal REM sleep latency for identifying patients with narcolepsy/hypocretin deficiency. JAMA neurology, 2013 Jul;70(7):891-902. doi: 10.1001/jamaneurol.2013.1589. Article ()
  • Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G, Melberg A, Cornelio F, Urban AE, Pizza F, Poli F, Grubert F, Wieland T, Graf E, Hallmayer J, Strom TM, Mignot E. Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.  Hum Mol Genet. 2012 May 15;21(10):2205-10.  Article () See also Pedroso JL, Barsottini OGP, Lin L, Melberg A, Oliveira ASB, Mignot E. A Novel de novo Exon 21 DNMT1 Mutation Causes Cerebellar Ataxia, Deafness and Narcolepsy in a Brazilian Patient. Sleep, 2013 Aug 1;36(8):1257-9, 1259A. doi: 10.5665/sleep.2898. Article ()
  • Andlauer O, Moore H 4th, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep. 2012 Sep 1;35(9):1247-55F.  Article ()
  • Mignot E.  A Practical Guide to the Therapy of Narcolepsy and Hypersomnia Syndromes. Neurotherapeutics, Neurotherapeutics. 2012 Oct;9(4):739-52.  Article ()
  • Han F, Lin L, Li J, Dong SX, An P, Zhao L, Liu NY, Li QY, Yan H, Gao ZC, Faraco J, Strohl KP, Liu X, Miyadera H, Mignot E. HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens. 2012 Oct;80(4):328-35. Article ()
  • Plazzi G, Pizza F, Palaia V, Franceschini C, Poli F, Moghadam KK, Cortelli P, Nobili L, Bruni O, Dauvilliers Y, Lin L, Edwards MJ, Mignot E, Bhatia KP. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011 Dec;134(Pt 12):3480-92. doi: 10.1093/brain/awr244. Epub 2011 Sep 19.  Article ()
  • Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.  Ann Neurol. 2011 Sep;70(3):410-7.
    Article
    () See also Han F, Lin L, Li J, Dong XS, Mignot E. Ann Neurol. 2012 Nov 9. doi: 10.1002/ana.23799. Article ()
  • Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan;43(1):66-71.  Article ()
  • Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, Kawashima M, Bayard S, Monaca C, Tiberge M, Filipini D, Tripathy A, Nguyen BH, Kotagal S, Mignot E.  Post-H1N1 Narcolepsy-Cataplexy Sleep 2010 33(11):1428-30.  
  • Mignot E, Dauvillers Y, Montplaisir J. Comment on the Letter to the Editor by Dr. Marcus on the association between narcolepsy and H1N1 exposure Sleep 2011, Vol. 34, 689-690. Article ()
  • Aran A, Einen M, Lin L, Plazzi G, Nishino S, Mignot E.  Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep 2010 33(11):1457-64 Article ()
  • Taheri S, Mignot E. (2010) Sleep well and stay slim: dream or reality? Ann Intern Med 2010 153(7):475-6. Comment ()
  • Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, Kawashima M, Bayard S, Monaca C, Tiberge M, Filipini D, Tripathy A, Nguyen BH, Kotagal S, Mignot E.  Post-H1N1 Narcolepsy-Cataplexy Sleep 2010 33(11):1428-30. Letter ()
  • Appelbaum L, Wang G, Yokogawa T, Skariah GM, Smith SJ, Mourrain P, Mignot E. Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons Neuron 2010 68(1):87-98 Article ()
  • Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep. 2010 33(7):869-74. Article ()
  • Appelbaum L, Wang GX, Maro GS, Mori R, Tovin A, Marin W, Yokogawa T, Kawakami K, Smith SJ, Gothilf Y, Mignot E, Mourrain P. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21942-7. Epub 2009 Dec 4. Article ()
  • Aran A, Lin L. Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009 32:979-983. Article ()
  • Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y,Mignot E. IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS ONE. 2009 4(1):e4254. Article ()
  • Hallmayer J, Faraco J, Lin L, Hesselson S, Winklemann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong S, Honda Y, Honda M, Högl B, Longstreth Jr WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poll F, Frauscher B, Jeong JH, Sung-Pil Lee SP, Ton TGN, Kvale M, Kolesar LB, Dobrovolna M, Nepom GT, Salomon D, HE, Rouleau  GA, Gieger C, Levinson  DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga  K, Kwock PY, Risch N, Mignot E.. Narcolepsy is strongly associated with the TCR alpha locus. Nature Genet 2009, 41(6):708-11. Article ()
  • Honda M, Arai T, Fukazawa M, Honda Y, Tsuchiya K, Salehi A, Akiyama H, Mignot E. Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy. Neurology 2009 73(7):511-7. Article ()
  • Berman JR, Skariah G, Maro GS, Mignot E, Mourrain P. Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system. J Comp Neurol.2009 517(5):695-710. Article ()
  • Arnulf I, Lin L, Gadoth N, File J, Lecendreux M, Franco P, Zeitzer J, Lo B, Faraco, JH, Mignot E. Kleine-Levin syndrome: a systematic study of 108 patients. Ann. Neurol.2008, 63(4):482-93.
  • Mignot E.  Why we sleep: Temporal organization of recovery. Plos Biol 2008 6(4):e106. Review ()
  • Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Rosa F, Mourrain P, Mignot E. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007, Oct 16;5(10):e277. Article ()
  • Hong S, Lin L, Lo B, Jeong J, Shin YK, Kim SY, Kweon Y, Zhang J, Einen, M, Smith A, Hansen J, Grument C, Mignot E DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans, Hum. Immunol. 2006, 68(1):59-68. Article ()
  • Crocker A, Espanan RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology 2005, 65(8):1184-8. Article ()
  • Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain. 2005 Dec;128(Pt 12):2763-76. Epub 2005 Oct 17. Article ()
  • Taheri S, Lin L, Austin D, Young T, Mignot E . Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PloS Medicine 2004, (3): e68, 1-8). Article ()
  • Zeitzer J, Buckmaster CL, Parker KJ, Hauck CM, Lyons DM, Mignot E Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J. Neurosci.2003, 23(8): 3555-3560. Article ()
  • Chabas D, Taheri S, Renier C, Mignot E. The genetics of narcolepsy. Annu. Rev. Genomics Hum. Genet. 2003, 4: 459-483. Review ()
  • Nishino S, Mignot E  A commentary on: Plasma orexin-A is lower in patients with narcolepsy. Sleep Med. 2002 3(4): 377-378. Comment ()
  • Mignot E, Taheri S, Nishino S. Sleeping with the Hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci. 2002 Nov;5 Suppl:1071-5. Article ().
  • Mignot E, Lammers GJ, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Bassetti C, Shrader H, Nishino S. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol. 2002 Oct;59(10):1553-62. Article ()
  • Mignot E. History of narcolepsy : a hundred years of research. Arch. Ital. Biol. 2001 Apr;139(3):207-20. Review. Article ()
  • Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu S, Leffell M, Grumet F, Fernandez-Vina M, Honda M, Risch N. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001 Mar;68(3):686-99. American Journal of Human Genetics, March 1st, 2001.
    Article ()
  • Hungs M, Mignot E. Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001 May;23(5):397-408. Article ()
  • Hungs M, Fan J, Lin L, Lin X, Maki RA, Mignot E. Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines. Genome Res. 2001 Apr;11(4):531-9. Article ()
  • Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001 Mar 1;21(5):1787-94. Article ()
  • Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep;6(9):991-7. Article ()
  • Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E.Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000 Jan 1;355(9197):39-40. Article ()
  • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999 Aug 6;98(3):365-76. Article ()
  • Anic-Labat S, Guilleminault C, Kraemer HC, Meehan J, Arrigoni J, Mignot E. Validation of a cataplexy questionnaire in 983 sleep-disorders patients. Sleep. 1999 Feb 1;22(1):77-87. Article ()
  • Mignot E. Genetic and familial aspects of narcolepsy. Neurology, 50(Suppl.1): 516-522, 1998.
  • Mignot E., Young T., Lin L., Finn L., Palta M. Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults. The Lancet 531: 727, 1998. Article ()
  • Nishino S., Mignot E. Pharmacological aspects of human and canine narcolepsy. Prog. Neurobiol. 52: 27-78, 1997. Article ()
  • Ellis M, Hetisimer AH, Ruddy DA, Hansen SL, Kronmal GS, McClelland E, Quintana L, Drayna DT, Aldrich MS, Mignot E. HLA Class II haplotype and sequence analysis support a role for DQ in narcolepsy. Immunogenetics, 46:410-417, 1997. Article ()
  • Mignot E, Kimura A, Lattermann A, Lin X, Yasunaga S, Mueller-Eckhardt G, Rattazzi C, Lin L, Guilleminault C, Grumet FC, Mayer G, Dement WC, Underhill P. Extensive HLA Class II studies in 58 non DRB1*15 (DR2) narcoleptic patients with cataplexy. Tissue Antigens, 49: 329-341, 1997.
  • Mignot E, Tafti M, Dement WC, Grumet FC. Narcolepsy and Immunity. Adv. Neuroimmunology 5 (1): 23-37, 1995.
  • Mignot E., Nishino S., Hunt-Sharp L., Arrigoni J., Siegel J.M., Reid M.S., Edgar D.M., Ciaranello R.D., Dement W.C. Heterozygocity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J. Neurosci, 13(3): 1057-1064, 1993.
  • Matsuki K., Grumet F.C., Lin X., Guilleminault C., Dement W.C., Mignot E. DQ rather than DR gene marks susceptibility to narcolepsy. The Lancet 339: 1052, 1992.
  • Mignot E., Wang C., Rattazzi C., Gaiser C., Lovett M., Guilleminault C., Dement W.C., Grumet F.C. Genetic linkage of autosomal recessive narcolepsy with an immunoglobulin µ chain switch-like segment. Proc. Natl. Acad. Sci. (USA), 88: 3475-3478, 1991.
  • Guilleminault C., Mignot E., Grumet C. Familial patterns of narcolepsy. The Lancet 333: 1376-1379, 1989.