Recent Publications

Associate Professor of Ophthalmology and, by courtesy, of Chemical Engineering

Publications

  • Electrospun Nanofiber Membrane for Cultured Corneal Endothelial Cell Transplantation. Bioengineering (Basel, Switzerland) Song, E., Chen, K. M., Margolis, M. S., Wungcharoen, T., Koh, W., Myung, D. 2024; 11 (1)

    Abstract

    The corneal endothelium, comprising densely packed corneal endothelial cells (CECs) adhering to Descemet's membrane (DM), plays a critical role in maintaining corneal transparency by regulating water and ion movement. CECs have limited regenerative capacity within the body, and globally, there is a shortage of donor corneas to replace damaged corneal endothelia. The development of a carrier for cultured CECs may address this worldwide clinical need. In this study we successfully manufactured a gelatin nanofiber membrane (gelNF membrane) using electrospinning, followed by crosslinking with glutaraldehyde (GA). The fabricated gelNF membrane exhibited approximately 80% transparency compared with glass and maintained a thickness of 20 m. The gelNF membrane demonstrated desirable permeability and degradability for a Descemet's membrane analog. Importantly, CECs cultured on the gelNF membrane at high densities showed no cytotoxic effects, and the expression of key CEC functional biomarkers was verified. To assess the potential of this gelNF membrane as a carrier for cultured CEC transplantation, we used it to conduct Descemet's membrane endothelial keratoplasty (DMEK) on rabbit eyes. The outcomes suggest this gelNF membrane holds promise as a suitable carrier for cultured CEC transplantation, offering advantages in terms of transparency, permeability, and sufficient mechanical properties required for successful transplantation.

    View details for DOI 10.3390/bioengineering11010054

    View details for PubMedID 38247931

  • Embedded 3d Bioprinting of Collagen Inks into Microgel Baths to control hydrogel Microstructure and Cell Spreading. Advanced healthcare materials Brunel, L. G., Christakopoulos, F., Kilian, D., Cai, B., Hull, S. M., Myung, D., Heilshorn, S. C. 2023: e2303325

    Abstract

    Microextrusion-based 3D bioprinting into support baths has emerged as a promising technique to pattern soft biomaterials into complex, macroscopic structures. We hypothesized that interactions between inks and support baths, which are often composed of granular microgels, could be modulated to control the microscopic structure within these macroscopic-printed constructs. Using printed collagen bioinks crosslinked either through physical self-assembly or bioorthogonal covalent chemistry, we demonstrate that microscopic porosity is introduced into collagen inks printed into microgel support baths but not bulk gel support baths. The overall porosity is governed by the ratio between the ink's shear viscosity and the microgel support bath's zero-shear viscosity. By adjusting the flow rate during extrusion, the ink's shear viscosity was modulated, thus controlling the extent of microscopic porosity independent of the ink composition. For covalently crosslinked collagen, printing into support baths comprised of gelatin microgels (15-50 µm) resulted in large pores (∼40 µm) that allowed human corneal mesenchymal stromal cells to readily spread, while control samples of cast collagen or collagen printed in non-granular support baths did not allow cell spreading. Taken together, these data demonstrate a new method to impart controlled microscale porosity into 3D printed hydrogels using granular microgel support baths. This article is protected by copyright. All rights reserved.

    View details for DOI 10.1002/adhm.202303325

    View details for PubMedID 38134346

  • AI-Human Hybrid Workflow Enhances Teleophthalmology for the Detection of Diabetic Retinopathy. Ophthalmology science Dow, E. R., Khan, N. C., Chen, K. M., Mishra, K., Perera, C., Narala, R., Basina, M., Dang, J., Kim, M., Levine, M., Phadke, A., Tan, M., Weng, K., Do, D. V., Moshfeghi, D. M., Mahajan, V. B., Mruthyunjaya, P., Leng, T., Myung, D. 2023; 3 (4): 100330

    Abstract

    Detection of diabetic retinopathy (DR) outside of specialized eye care settings is an important means of access to vision-preserving health maintenance. Remote interpretation of fundus photographs acquired in a primary care or other nonophthalmic setting in a store-and-forward manner is a predominant paradigm of teleophthalmology screening programs. Artificial intelligence (AI)-based image interpretation offers an alternative means of DR detection. IDx-DR (Digital Diagnostics Inc) is a Food and Drug Administration-authorized autonomous testing device for DR. We evaluated the diagnostic performance of IDx-DR compared with human-based teleophthalmology over 2 and a half years. Additionally, we evaluated an AI-human hybrid workflow that combines AI-system evaluation with human expert-based assessment for referable cases.Prospective cohort study and retrospective analysis.Diabetic patients ≥ 18 years old without a prior DR diagnosis or DR examination in the past year presenting for routine DR screening in a primary care clinic.Macula-centered and optic nerve-centered fundus photographs were evaluated by an AI algorithm followed by consensus-based overreading by retina specialists at the Stanford Ophthalmic Reading Center. Detection of more-than-mild diabetic retinopathy (MTMDR) was compared with in-person examination by a retina specialist.Sensitivity, specificity, accuracy, positive predictive value, and gradability achieved by the AI algorithm and retina specialists.The AI algorithm had higher sensitivity (95.5% sensitivity; 95% confidence interval [CI], 86.7%-100%) but lower specificity (60.3% specificity; 95% CI, 47.7%-72.9%) for detection of MTMDR compared with remote image interpretation by retina specialists (69.5% sensitivity; 95% CI, 50.7%-88.3%; 96.9% specificity; 95% CI, 93.5%-100%). Gradability of encounters was also lower for the AI algorithm (62.5%) compared with retina specialists (93.1%). A 2-step AI-human hybrid workflow in which the AI algorithm initially rendered an assessment followed by overread by a retina specialist of MTMDR-positive encounters resulted in a sensitivity of 95.5% (95% CI, 86.7%-100%) and a specificity of 98.2% (95% CI, 94.6%-100%). Similarly, a 2-step overread by retina specialists of AI-ungradable encounters improved gradability from 63.5% to 95.6% of encounters.Implementation of an AI-human hybrid teleophthalmology workflow may both decrease reliance on human specialist effort and improve diagnostic accuracy.Proprietary or commercial disclosure may be found after the references.

    View details for DOI 10.1016/j.xops.2023.100330

    View details for PubMedID 37449051

    View details for PubMedCentralID PMC10336195

  • Artificial Intelligence Improves Patient Follow-Up in a Diabetic Retinopathy Screening Program. Clinical ophthalmology (Auckland, N.Z.) Dow, E. R., Chen, K. M., Zhao, C. S., Knapp, A. N., Phadke, A., Weng, K., Do, D. V., Mahajan, V. B., Mruthyunjaya, P., Leng, T., Myung, D. 2023; 17: 3323-3330

    Abstract

    We examine the rate of and reasons for follow-up in an Artificial Intelligence (AI)-based workflow for diabetic retinopathy (DR) screening relative to two human-based workflows.A DR screening program initiated September 2019 between one institution and its affiliated primary care and endocrinology clinics screened 2243 adult patients with type 1 or 2 diabetes without a diagnosis of DR in the previous year in the San Francisco Bay Area. For patients who screened positive for more-than-mild-DR (MTMDR), rates of follow-up were calculated under a store-and-forward human-based DR workflow ("Human Workflow"), an AI-based workflow involving IDx-DR ("AI Workflow"), and a two-step hybrid workflow ("AI-Human Hybrid Workflow"). The AI Workflow provided results within 48 hours, whereas the other workflows took up to 7 days. Patients were surveyed by phone about follow-up decisions.Under the AI Workflow, 279 patients screened positive for MTMDR. Of these, 69.2% followed up with an ophthalmologist within 90 days. Altogether 70.5% (N=48) of patients who followed up chose their location based on primary care referral. Among the subset of patients that were seen in person at the university eye institute under the Human Workflow and AI-Human Hybrid Workflow, 12.0% (N=14/117) and 11.7% (N=12/103) of patients with a referrable screening result followed up compared to 35.5% of patients under the AI Workflow (N=99/279; χ2df=2 = 36.70, p < 0.00000001).Ophthalmology follow-up after a positive DR screening result is approximately three-fold higher under the AI Workflow than either the Human Workflow or AI-Human Hybrid Workflow. Improved follow-up behavior may be due to the decreased time to screening result.

    View details for DOI 10.2147/OPTH.S422513

    View details for PubMedID 38026608

    View details for PubMedCentralID PMC10665027

  • Automated Detection of Dysthyroid Optic Neuropathy in Graves' Ophthalmopathy with Computed Tomography (CT) Scans by Convolutional Neural Networks Hung, J., Luo, A., Deng, Y., Chung, C., Fuh, C., Perera, C., Myung, D., Kossler, A., Liao, S. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023
  • Impact of crosslinking chemistry on corneal tissue regeneration after in situforming collagen-hyaluronate matrix therapy Wungcharoen, T., Chen, F., Seo, Y., Myung, D. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023
  • SCONE: Development of optic nerve head delivery technology Chiang, B., Dalal, R., Heng, K., Liao, Y., Goldberg, J. L., Myung, D. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023
  • Real world outcomes from artificial intelligence to detect diabetic retinopathy in the primary care setting: 12 month experience Knapp, A. N., Dow, E., Chen, K., Khan, N. C., Do, D. V., Mahajan, V., Mruthyunjaya, P., Leng, T., Myung, D. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023
  • Collagen Gels Crosslinked by Photoactivation of Riboflavin for the Repair and Regeneration of Corneal Defects. ACS applied bio materials Fernandes-Cunha, G. M., Brunel, L. G., Arboleda, A., Manche, A., Seo, Y. A., Logan, C., Chen, F., Heilshorn, S. C., Myung, D. 2023

    Abstract

    Bioengineered corneal tissue is a promising therapeutic modality for the treatment of corneal blindness as a substitute for cadaveric graft tissue. In this study, we fabricated a collagen gel using ultraviolet-A (UV-A) light and riboflavin as a photosensitizer (PhotoCol-RB) as an in situ-forming matrix to fill corneal wounds and create a cohesive interface between the crosslinked gel and adjacent collagen. The PhotoCol-RB gels supported corneal epithelialization and exhibited higher transparency compared to physically crosslinked collagen. We showed that different riboflavin concentrations yielded gels with different mechanical and biological properties. In vitro experiments using human corneal epithelial cells (hCECs) showed that hCECs are able to proliferate on the gel and express corneal cell markers such as cytokeratin 12 (CK12) and tight junctions (ZO-1). Using an ex vivo burst assay, we also showed that the PhotoCol-RB gels are able to seal corneal perforations. Ex vivo organ culture of the gels filling lamellar keratectomy wounds showed that the epithelium that regenerated over the PhotoCol-RB gels formed a multilayer compared to just a double layer for those that grew over physically cross-linked collagen. These gels can be formed either in situ directly on the wound site to conform to the geometry of a defect, or can be preformed and then applied to the corneal wound. Our results indicate that PhotoCol-RB gels merit further investigation as a way to stabilize and repair deep and perforating corneal wounds.

    View details for DOI 10.1021/acsabm.3c00015

    View details for PubMedID 37126648

  • In Situ-Forming Collagen-Hyaluronate Semi-Interpenetrating Network Hydrogel Enhances Corneal Defect Repair. Translational vision science & technology Chen, F., Mundy, D. C., Le, P., Seo, Y. A., Logan, C. M., Fernandes-Cunha, G. M., Basco, C. A., Myung, D. 2022; 11 (10): 22

    Abstract

    Purpose: Millions worldwide suffer vision impairment or blindness from corneal injury, and there remains an urgent need for a more effective and accessible way to treat corneal defects. We have designed and characterized an in situ-forming semi-interpenetrating polymer network (SIPN) hydrogel using biomaterials widely used in ophthalmology and medicine.Methods: The SIPN was formed by cross-linking collagen type I with bifunctional polyethylene glycol using N-hydroxysuccinimide ester chemistry in the presence of linear hyaluronic acid (HA). Gelation time and the mechanical, optical, swelling, and degradation properties of the SIPN were assessed. Cytocompatibility with human corneal epithelial cells and corneal stromal stem cells (CSSCs) was determined in vitro, as was the spatial distribution of encapsulated CSSCs within the SIPN. In vivo wound healing was evaluated by multimodal imaging in an anterior lamellar keratectomy injury model in rabbits, followed by immunohistochemical analysis of treated and untreated tissues.Results: The collagen-hyaluronate SIPN formed in situ without an external energy source and demonstrated mechanical and optical properties similar to the cornea. It was biocompatible with human corneal cells, enhancing CSSC viability when compared with collagen gel controls and preventing encapsulated CSSC sedimentation. In vivo application of the SIPN significantly reduced stromal defect size compared with controls after 7 days and promoted multilayered epithelial regeneration.Conclusions: This in situ-forming SIPN hydrogel may be a promising alternative to keratoplasty and represents a step toward expanding treatment options for patients suffering from corneal injury.Translational Relevance: We detail the synthesis and initial characterization of an SIPN hydrogel as a potential alternative to lamellar keratoplasty and a tunable platform for further development in corneal tissue engineering and therapeutic cell delivery.

    View details for DOI 10.1167/tvst.11.10.22

    View details for PubMedID 36239965

Publications By Year

2024

  • Song E, Chen KM, Margolis MS, Wungcharoen T, Koh WG, Myung D. Electrospun Nanofiber Membrane for Cultured Corneal Endothelial Cell Transplantation. Bioengineering. 2024 Jan 5;11(1):54.

2023

  • Brunel LG, Christakopoulos F, Kilian D, Cai B, Hull SM, Myung D, Heilshorn SC. Embedded 3d Bioprinting of Collagen Inks into Microgel Baths to control hydrogel Microstructure and Cell Spreading. Advanced Healthcare Materials 2023 Dec 22:e2303325. doi: 10.1002/adhm.202303325. Epub ahead of print. PMID: 38134346.

  • Dow ER, Chen KM, Zhao CS, Knapp AN, Phadke A, Weng K, Do DV, Mahajan VB, Mruthyunjaya P, Leng T, Myung D. Artificial Intelligence Improves Patient Follow-Up in a Diabetic Retinopathy Screening Program. Clinical Ophthalmology. 2023 Dec 31:3323-30.

  • Dow ER, Khan NC, Chen KM, Mishra K, Perera C, Narala R, Basina M, Dang J, Kim M, Levine M, Phadke A, Tan M, Weng K, Do DV, Moshfeghi DM, Mahajan VB, Mruthyunjaya P, Leng T, Myung D. AI-Human Hybrid Workflow Enhances Teleophthalmology for the Detection of Diabetic Retinopathy. Ophthalmol Sci. 2023 May 12;3(4):100330. doi: 10.1016/j.xops.2023.100330. PMID: 37449051; PMCID: PMC10336195.

  • Medeiros FA, Lee T, Jammal AA, Al-Aswad LA, Eydelman MB, Schuman JS, Abramoff M, Blumenkranz M, Chew E, Chiang M, Eydelman M. The Definition of Glaucomatous Optic Neuropathy in Artificial Intelligence Research and Clinical Applications. Ophthalmology Glaucoma. 2023 Jan 31.

  • Parajuli A, Collon S, Myung D, Thapa S. Teleophthalmology in Nepal. InDigital Eye Care and Teleophthalmology: A Practical Guide to Applications 2023 Jun 20 (pp. 495-503). Cham: Springer International Publishing.

  • Khan N, Myung D. Smartphone Technology for Teleophthalmology. In Digital Eye Care and Teleophthalmology: A Practical Guide to Applications 2023 Jun 20 (pp. 37-53). Cham: Springer International Publishing.


  • Chen K, Dow E, Basina M, Dang J, Khan N, Kim M, Levine ML, Mishra K, Perera C, Phadke A, Tan M. Improved access to diabetic retinopathy screening through primary care-based teleophthalmology during the COVID-19 pandemic. medRxiv. 2023:2023-05.
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  • Gabriella Maria Fernandes-Cunha, Lucia G. Brunel, Alejandro Arboleda, Alyssa Manche, Youngyoon Amy Seo, Caitlin Logan, Fang Chen, Sarah C. Heilshorn, and David Myung. Collagen Gels Crosslinked by Photoactivation of Riboflavin for the Repair and Regeneration of Corneal Defects. ACS Applied Bio Materials, Articles ASAP. 2023 May 1. https://pubs.acs.org/doi/10.1021/acsabm.3c00015

2022

  • Cui, K. W., Myung, D. J., Fuller, G. G. Tear Film Stability as a Function of Tunable Mucin Concentration Attached to Supported Lipid Bilayers. JOURNAL OF PHYSICAL CHEMISTRY B2022, DOI 10.1021/acs.jpcb.2c04154AJ 
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  • Logan, C. M., Fernandes-Cunha, G. M., Chen, F., Le, P., Mundy, D., Na, K. S., Myung, D. In Situ-forming Collagen Hydrogels Crosslinked by Multifunctional Polyethylene Glycol as a Matrix Therapy for Corneal Defects: 2-Month Follow-Up In Vivo. Cornea2022, DOI 10.1097/ICO.0000000000003104

 

Mun J, Kim TY, Myung D, Hahn SK. Smart contact lens containing hyaluronate–rose bengal conjugate for biophotonic myopia vision correction. Biomaterials Science. 2022, In Press

 


Khan NC, Perera C, Dow ER, Chen KM, Mahajan VB, Mruthyunjaya P, Do DV, Leng T, Myung D. Predicting Systemic Health Features from Retinal Fundus Images Using Transfer-Learning-Based Artificial Intelligence Models. Diagnostics. 2022; 12(7):1714. https://doi.org/10.3390/diagnostics12071714 

 


Park SK, Ha M, Kim EJ, Seo YA, Lee HJ, Myung D, Kim HS, Na KS. Hyaluronic acid hydrogels crosslinked via blue light-induced thiol-ene reaction for the treatment of rat corneal alkali burn. Regenerative Therapy, 2022 Mar 30;20:51-60. doi: 10.1016/j.reth.2022.03.005. PMID: 35402662; PMCID: PMC8971597.

 


Kim SK, Lee GH, Jeon C, Han HH, Kim SJ, Mok JW, Joo CK, Shin S, Sim JY, Myung D, Bao Z, Hahn SK. Bimetallic Nanocatalysts Immobilized in Nanoporous Hydrogels for Long-Term Robust Continuous Glucose Monitoring of Smart Contact Lens. Adv Mater. 2022 May;34(18):e2110536. doi: 10.1002/adma.202110536. Epub 2022 Mar 13. PMID: 35194844.

 


Blumenkranz MS, Tarver ME, Myung D, Eydelman MB; Collaborative Community on Ophthalmic Imaging Executive Committee. The Collaborative Community on Ophthalmic Imaging: Accelerating Global Innovation and Clinical Utility. Ophthalmology. 2022 Feb;129(2):e9-e13. doi: 10.1016/j.ophtha.2021.10.001. Epub 2021 Nov 10. PMID: 34774340.

 


Hung JY, Chen KW, Perera C, Chiu HK, Hsu CR, Myung D, Luo AC, Fuh CS, Liao SL, Kossler AL. An Outperforming Artificial Intelligence Model to Identify Referable Blepharoptosis for General Practitioners. Journal of Personalized Medicine, 2022 Feb 15;12(2):283. doi: 10.3390/jpm12020283. PMID: 35207771; PMCID: PMC8877622.

 


Madl AC, Liu C, Cirera-Salinas D, Fuller GG, Myung D. A Mucin-Deficient Ocular Surface Mimetic Platform for Interrogating Drug Effects on Biolubrication, Antiadhesion Properties, and Barrier Functionality. ACS Appl Mater Interfaces. 2022 Apr 27;14(16):18016-18030. doi: 10.1021/acsami.1c22280. Epub 2022 Apr 13. PMID: 35416028; PMCID: PMC9052192.

 


Kim DG, Webel AD, Blumenkranz MS, Kim Y, Yang JH, Yu SY, Kwak HW, Palanker D, Toy B, Myung D. A Smartphone-Based Near-Vision Testing System: Design, Accuracy, and Reproducibility Compared With Standard Clinical Measures. Ophthalmic Surg Lasers Imaging Retina. 2022 Feb;53(2):79-84. doi: 10.3928/23258160-20220121-05. Epub 2022 Feb 1. PMID: 35148218. 

 

2021

Fernandes-Cunha GM, Jeong SH, Logan CM, Le P, Mundy D, Chen F, Chen KM, Kim M, Lee GH, Na KS, Hahn SK, and Myung D. Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects. The Ocular Surface, 2021 Sep 16:S1542-0124(21)00101-4. doi: 10.1016/j.jtos.2021.09.002. Epub ahead of print. PMID: 34537415.

 


Kim DG, Webel A, Blumenkranz MS, Kim Y, Yang JH, Yu SY, Palanker D, Toy B, and Myung D. A Smartphone-based Near Vision Testing System: Design, Accuracy, and Reproducibility Compared with Standard Clinical Measures, OSLI Retina, 2021. In Press.

 


Chen F, Bian M, Nahmou M, Myung D, and Goldberg JL. Fusogenic Liposome-Enhanced Cytosolic Delivery of Magnetic Nanoparticles. RSC Advances, 2021; 11 (57): 35796-35805

 


Le, P., Chen, F., Myung, D. Development of Simple Inner-Stopper Guarded Trephine to Create Consistent Keratectomy Wounds in Rodents. Journal of Ophthalmic and Vision Research 2021. In Press.  

 


Liu TYA, Wei J, Zhu H, Subramanian PS, Myung D, Yi PH, Hui FK, Unberath M, Ting DSW, Miller NR. Detection of Optic Disc Abnormalities in Color Fundus Photographs Using Deep Learning. J Neuroophthalmol. 2021 Sep 1;41(3):368-374. doi: 10.1097/WNO.0000000000001358. PMID: 34415271.

 


Kim TY, Shin S, Choi H, Jeong SH, Myung D, and Hahn SK. Smart Contact Lens with Integrated Transparent Silver Nanowire Sensor for Continuous Intraocular Pressure Monitoring. ACS Applied Biomaterials, 2021. In Press.  

 


Liu C, Madl AC, Cirera-Salinas D, Kress W, Straube F, Myung D, and Fuller GG. Mucin-like Glycoproteins Modulate Interfacial Properties of a Mimetic Ocular Epithelial Surface. Advanced Science, 2021. In Press.

 


Na KS, Fernandes-Cunha GM, Blanco Varela I, Lee HJ, Seo YA, and Myung D. Effect of mesenchymal stem cells encapsulated within in situ forming PEG-collagen hydrogels on alkali burns in a corneal organ culture model, Cytotherapy, 2021. Mar 19;S1465-3249(21)00034-7. PMID: 33752960 

 


Idriss BR, Tran TM, Atwine D, Chang RT, Myung D, Onyango J. Smartphone-Based Ophthalmic Imaging Compared to Spectral Domain Optical Coherence Tomography Assessment of Vertical Cup-to-Disc Ratio among Adults in Southwestern Uganda, Journal of Glaucoma, 2021, Mar 1;30(3):e90-e98. PMID: 33394852

 


Hung JY, Perera C, Chen KW, Myung D, Chiu HK, Fuh CS, Hsu CR, Liao SL, Kossler AL. A deep learning approach to identify blepharoptosis by convolutional neural networks. International journal of medical informatics, 2021; 148: 104402 

 


Na K, Fernandes-Cunha G, Seo A, Blanco-Varela I, Lee H, and Myung D. Effect of mesenchymal stem cells encapsulated within in situ forming PEG-collagen hydrogels on alkali burned-corneas in an ex vivo organ culture model. Cytotherapy. 2021; In Press.

 


Chen F, Buickians D, Le P, Mundy DC, Xia X, Montague-Alamin SQ, Blanco I, Logan CM, and Myung D. 3D Printable, Modified Trephine Designs for Consistent Anterior Lamellar Keratectomy Wounds in Rabbits. Current Eye Research, 2021. In Press.

 


Chun YH, Park SK, Kim EJ, Lee HJ, Kim H, Koh WG, Cunha GF, Myung D, Na KS. In vivo biocompatibility evaluation of in situ-forming polyethylene glycol-collagen hydrogels in corneal defects. Sci Rep. 2021 Dec 13;11(1):23913. doi: 10.1038/s41598-021-03270-3. PMID: 34903788; PMCID: PMC8668970.

 

2020

Sayadi JJ, Lam H, Lin CC, and Myung D. Management of Acute Corneal Hydrops with Intracameral Gas Injections. American Journal of Ophthalmology Case Reports, 2020 In Press. 

 


Hull SM, Lindsay C, Shiwarski DJ, Tashman JW, Myung D, Feinberg AW, and Heilshorn SC. 3D Bioprinting using UNIversal Orthogonal Network (UNION) Bioinks. Advanced Functional Materials, 2020, Vol. 20: 100994. 

 


Fernandes-Cunha G, Chen K, Chen F, Le P, Han JH, Mahajan LA, Lee HJ, Na KS, Myung DIn situ-forming collagen hydrogel crosslinked via multi-functional PEG as a matrix therapy for corneal defects. Scientific Reports. 2020, 7;10(1):16671. PMID: 33028837

 


Ludwig C, Perera C, Myung D, Smith S, Chang R, and Leng T. Automatic Identification of Referral-Warranted Diabetic Retinopathy using Deep Learning on Mobile Phone Images. Translational Vision Science & Technology (TVST), 2020, In Press.

 


Idriss BR, Tran TM, Atwine D, Chang RT, Myung D, Onyango J. Smartphone-Based Ophthalmic Imaging Compared to Spectral Domain Optical Coherence Tomography Assessment of Vertical Cup-to-Disc Ratio among Adults in Southwestern Uganda, Journal of Glaucoma, 2020, In Press.

 


Chen F, Peng S, de la Zerda A, Jokerst JV, and Myung D. Gold nanoparticles to enhance ophthalmic imaging, Biomaterials Science, 2020. In Press.

 


Madl A, Fuller G, and Myung D. Modeling and Restoring the Ocular Surface Lubrication. Current Ophthalmology Reports2020 (8), pp. 281–300(2020)

 


Brodie F, Repka M, Burns SA, Prakalapakorn SG, Morse C, Schuman JS, Duenas MD, Afshari N, Pollack JS, Thorne J, Vitale A, Nida Sen H, Myung D, Blumenkranz MS, Tu, E, Hammer D, Tarver M, Cunningham B, Kagemann L, Sadda SV, Sarraf D, Jaffe GJ, and Eydelman M, Development, Validation and Innovation in Ophthalmic Laser Based Imaging: Report from an FDA co-sponsored forum. JAMA Ophthalmology, 2020 Nov 19. doi: 10.1001/jamaophthalmol.2020.4994. Online ahead of print.  PMID: 33211074

 


Han Y, Pan C, Leung LS, Blumenkranz M, Myung D, and Toy B. Comparison of Telemedicine Screening of Diabetic Retinopathy by Mydriatic Smartphone-Based and NonMydriatic Table-Top Camera-Based Fundus Imaging. Journal of Vitreoretinal Diseases, Oct 2020.  doi.org/10.1177/2474126420958304

 


Rosenblatt TR, Myung D, Fischbein, Steinberg GK, and Kossler A.  Microsurgical Resection of an Orbital Arterovenous Malformation with Intraoperative Digital Subtraction Angiography. Ophthalmic Plastic and Reconstructive Surgery, Sept. 2020. EPub ahead of print. PMID: 32976328

 


Veerappan-Paricha M, Jelks A, Myung D, and Pan C. Nonmydriatic Photographic Screening for Diabetic Retinopathy in Pregnant Patients with Preexisting Diabetes in a Safety Net Population: 1 Year Results from the Diabetic Retinopathy in Pregnant Patients (DRIPP) Study. Women’s Health Reports, Oct 2020. 1(1)  pp. 436-443.

 


Sayadi J, Ta CN, Myung D. “Anatomy and Physiology of the Cornea and Sensory Nerves.”  Book chapter in Techniques in Corneal Neurotization, Edited by IM Leyngold, AL Kossler, MT Yen, 2020. Quality Medical Publishing

 


Chen F, Le P, Fernandes-Cunha GM, Heilshorn SC, and Myung D. Bio-orthogonally crosslinked hyaluronate-collagen hydrogel for suture-free corneal defect repair. Biomaterials, 2020. In Press. doi.org/10.1016/j.biomaterials.2020.120176

 


Chen F, Le P, Lai K, Fernandes-Cunha GM, and Myung D. Simultaneous Interpenetrating Polymer Network of Collagen and Hyaluronic Acid as an In Situ-Forming Corneal Defect Filler.  Chemistry of Materials, 2020, In Press. doi.org/10.1021/acs.chemmater.0c0130z

 


Madl AC, Madl CM, Myung D. Injectable Cucurbit[8]uril-Based Supramolecular Gelatin Hydrogels for Cell Encapsulation. ACS Macro Letters. 2020; 9:619-626.

 


Lai KY, Pathipati MP, Blumenkranz MS, Leung LS, Moshfeghi DM, Toy BC, and Myung D. Assessment of eye disease and visual impairment in the nursing home population using mobile health technology.  OSLI Retina, 2020, In Press.

 


Keum DH, Kim SK, Koo JH, Lee GH, Jeon C, Mok JW, Mun BH, Lee KJ, Kamrani E, Joo CK, Shin S, Sim JY, Myung D, Yun SH, Bao Z, Hahn SK. Wireless Smart Contact Lens for Diabetic Diagnosis and Therapy. Science Advances. 2020 April; 6(17):1-13.

 


Lee GH, Moon H, Kim H, Kwon W, Yoo SH, Myung D, Yu SK, Bao Z, Hahn SK. Multifunctional Materials for Implantable and Wearable Photonic Healthcare Devices. Nature Reviews Materials. 2020; 5:149-165.

 


Collon S, Chang D, Hong, K, Tabin G, Ruit S, Myung D, and Thapa S. Utility and feasibility of teleophthalmology using a smartphone-based ophthalmic camera in village screening camps in Nepal.  Asia-Pacific Journal of Ophthalmology2020, Jan-Feb;9(1): 54-58. doi: 10.1097/01.APO.0000617936.16124.ba. PMID:31990747

 

2019

Carter K, Lee HJ, Na KS, Fernandez-Cunha G, Blanco I, Djalilian AR, and Myung D. Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cells on corneal wound healing in vitro and ex vivo.  Acta Biomaterialia, 2019, 9, pp. 247-257; PMID:31539656


Fernandes-Cunha F, Na KS, Putra I, Lee HJ, Hull S, Cheng YC, Blanco IJ, Eslani M, Djalilian AR, and Myung D.  Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered within a Viscoelastic Gel Carrier. Stem Cells Translational Medicine, 2019; 8(5), pp. 478-489.

 


Hong K, Collon S, Chang D, Thakalli S, Welling J, Oliva M, Peralta P, Gurung R, Ruit S, Tabin G, Myung D, and Thapa S. Teleophthalmology through handheld mobile devices: a pilot study in rural Nepal, Journal of Mobile Technology in Medicine, 2019, 8(1), pp. 1–10

 


Bodnar ZM, Schuchard R, Myung D, Tarver ME, Blumenkranz M, Afshari NA, Humayun, MS, Morse C, Nischal K, Repka MX, Sprunger D, Trese M, and Eydelman M.  Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development. JAMA Ophthalmology, 2019, 137(8):939-944. PMID: 31169870

 

2018

Lee HJ, Fernandes-Cunha G, Na KS, Hull SM, and Myung D. Bio-orthogonally Crosslinked, In Situ-forming Corneal Stromal Tissue Substitute. Advanced Healthcare Materials, 2018,7(19) https://doi.org/10.1002/adhm.201800560

 


Lee HJ, Fernandes-Cunha G, and Myung D.  In Situ-Forming Hyaluronic Acid Hydrogel through Visible Light-Induced Thiol-Ene Reaction. Reactive and Functional Polymers, 2018. 131, pp. 29-35. https://doi.org/10.1016/j.reactfunctpolym.2018.06.010

 

2017

Mercado C, Welling J, Oliva M, Li, J, Gurung R, Ruit S, Tabin G, Chang D, Thapa S, and Myung D. Clinical Application of a Smartphone-Based Ophthalmic Camera Adapter in Under-Resourced Settings in Nepal. Journal of Mobile Technology in Medicine, 2017. 6(3) pp. 34-42.

 


Fernandes-Cunha G, Lee HJ, Kumar A, Kreymerman A, Heilshorn S, Myung D. Immobilization of Growth Factors to Collagen Surfaces Using Pulsed Visible Light. Biomacromolecules, 2017. DOI: 10.1021/acs.biomac.7b00838

 


Lee HJ, Fernandes-Cunha G, Putra I, Koh WG, Myung D. Tethering Growth Factors to Collagen Surfaces Using Copper-free Click Chemistry: Surface Characterization and In Vitro Biological Response. ACS Applied Materials and Interfaces, 2017. DOI: 10.1021/acsami.7b05262

 

2016

Toy B, Myung D, He L, Pan C, Chang R, Polkinhorne A, Merrell D, Foster D, Blumenkranz M.   Smartphone Ophthalmoscopy Adapter as an Inexpensive Screening Tool to Detect Referral-Warranted Diabetic Retinopathy. Retina2016, Vol 36 Issue 5: 1000-1008.