Mormino Lab Publications

Early Tau accumulation is detected within the medial temporal lobe using Tau PET imaging. 

Trelle AN, Carr VA, Guerin SA, Thieu MK, Jayakumar M, Guo W, Nadiadwala A, Corso NK, Hunt MP, Litovsky CP, Tanner NJ, Deutsch GK, Bernsteing JD, Harrison MB,Khazenzon AM, Jiang J, Sha SJ, Fredericks CA, Rutt BK, Mormino EC, Kerchner GA, Wagner AD. Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. eLife 2020;9:e55335 doi: 10.7554/eLife.55335

Hansson O, Mormino EC. Is longitudinal tau PET ready for use in Alzheimer's disease clinical trials? Brain. 2018 May 1;141(5):1241-1244. doi: 10.1093/brain/awy065. PubMed PMID: 29701788.

Ge T, Sabuncu MR, Smoller JW, Sperling RA, Mormino EC; Alzheimer's Disease Neuroimaging Initiative. Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition. Neurology. 2018 May 1;90(18):e1605-e1612. doi: 10.1212/WNL.0000000000005415. Epub 2018 Mar 28. PubMed PMID: 29592889; PubMed Central PMCID: PMC5931806.

Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5. Alzheimers Dement (N Y). 2017 Nov 10;3(4):668-677. doi: 10.1016/j.trci.2017.10.004. eCollection 2017 Nov. PubMed PMID: 29264389; PubMed Central PMCID: PMC5726754.

Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS; Alzheimer’s Disease Neuroimaging Initiative. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 Jan;135(1):85-93. doi: 10.1007/s00401-017-1789-4. Epub 2017 Nov 24. PubMed PMID: 29177679; PubMed Central PMCID: PMC5758038.

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA Neurol. 2017 Dec 1;74(12):1455-1463. doi: 10.1001/jamaneurol.2017.2216. PubMed PMID: 28973551; PubMed Central PMCID: PMC5774633.

Lim YY, Mormino EC; Alzheimer's Disease Neuroimaging Initiative. APOE genotype and early β-amyloid accumulation in older adults without dementia. Neurology. 2017 Sep 5;89(10):1028-1034. doi: 10.1212/WNL.0000000000004336. Epub 2017 Aug 9. PubMed PMID: 28794245; PubMed Central PMCID: PMC5589795.

Roe CM, Babulal GM, Head DM, Stout SH, Vernon EK, Ghoshal N, Garland B, Barco PP, Williams MM, Johnson A, Fierberg R, Fague MS, Xiong C, Mormino E, Grant EA, Holtzman DM, Benzinger TLS, Fagan AM, Ott BR, Carr DB, Morris JC. Preclinical Alzheimer's disease and longitudinal driving decline. Alzheimers Dement (N Y). 2017 Jan;3(1):74-82. doi: 10.1016/j.trci.2016.11.006. PubMed PMID: 28435853; PubMed Central PMCID: PMC5396459.

Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 Apr 19;37(16):4323-4331. doi: 10.1523/JNEUROSCI.3263-16.2017. Epub 2017 Mar 17.
PubMed PMID: 28314821; PubMed Central PMCID: PMC5413178.

Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. 2017 Apr 11;88(15):1431-1438. doi: 10.1212/WNL.0000000000003812. Epub 2017 Mar 10. PubMed PMID: 28283594; PubMed Central PMCID: PMC5386436.

Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr;81(4):583-596. doi: 10.1002/ana.24910. Epub 2017 Apr 6. PubMed PMID: 28253546; PubMed Central PMCID: PMC5404378.

Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β. Alzheimers Dement. 2017 Sep;13(9):1004-1012. doi: 10.1016/j.jalz.2017.01.018. Epub 2017 Feb 28. PubMed PMID: 28253478; PubMed Central PMCID: PMC5573651.

Mormino EC, Wolk DA, Apostolova LG. Introduction to special edition, "State of the Field: Advances in Neuroimaging from the 2016 Alzheimer's Imaging Consortium". Alzheimers Dement (Amst). 2016 Dec 21;5:67-69. doi: 10.1016/j.dadm.2016.12.008. eCollection 2016. PubMed PMID: 28054029; PubMed Central PMCID: PMC5198873.

Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL; Alzheimer's Disease Neuroimaging Initiative. Asymptomatic Alzheimer disease: Defining resilience. Neurology. 2016 Dec 6;87(23):2443-2450. Epub 2016 Nov 4. PubMed PMID: 27815399; PubMed Central PMCID: PMC5177674.

Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT; Alzheimer’s Disease Neuroimaging Initiative. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6535-E6544. Epub 2016 Oct 4. PubMed PMID: 27702899; PubMed Central PMCID: PMC5081632.

Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging Behav. 2017 Apr;11(2):383-390. doi: 10.1007/s11682-016-9640-4. PubMed PMID: 27738998; PubMed Central PMCID: PMC5391311.

Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurol. 2016 Oct 1;73(10):1185-1191. doi: 10.1001/jamaneurol.2016.2237. PubMed PMID: 27548655; PubMed Central PMCID: PMC5266522.

Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative. Polygenic risk of Alzheimer disease is associated with early- and late-life processes. Neurology. 2016 Aug 2;87(5):481-8. doi: 10.1212/WNL.0000000000002922. Epub 2016 Jul 6. PubMed PMID: 27385740; PubMed Central PMCID: PMC4970660.

Hsu DC, Mormino EC, Schultz AP, Amariglio RE, Donovan NJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA; Harvard Aging Brain Study. Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly. J Alzheimers Dis. 2016 Jun 18;53(3):1097-105. doi: 10.3233/JAD-150987. PubMed PMID: 27340843; PubMed Central PMCID: PMC4976009.

Mormino EC, Papp KV. Cognitive Decline in Preclinical Stage 2 Alzheimer Disease and Implications for Prevention Trials. JAMA Neurol. 2016 Jun 1;73(6):640-2. doi: 10.1001/jamaneurol.2016.0281. PubMed PMID: 27064971.

Jack CR Jr, Knopman DS, Chételat G, Dickson D, Fagan AM, Frisoni GB, Jagust W, Mormino EC, Petersen RC, Sperling RA, van der Flier WM, Villemagne VL, Visser PJ, Vos SJ. Suspected non-Alzheimer disease pathophysiology--concept and controversy. Nat Rev Neurol. 2016 Feb;12(2):117-24. doi: 10.1038/nrneurol.2015.251. Epub 2016 Jan 18. Review. PubMed PMID: 26782335; PubMed Central PMCID: PMC4784257.

Papp KV, Mormino EC, Amariglio RE, Munro C, Dagley A, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease. Neuropsychology. 2016 Jul;30(5):624-30. doi: 10.1037/neu0000246. Epub 2015 Nov 23. PubMed PMID: 26595826; PubMed Central PMCID: PMC4877295.

Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan;79(1):110-9. doi: 10.1002/ana.24546. Epub 2015 Dec 15. PubMed PMID: 26505746; PubMed Central PMCID: PMC4738026.

Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P, Johnson KA, Sperling RA, Rentz DM. Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly. Neurology. 2015 Jul 7;85(1):56-62. doi:  10.1212/WNL.0000000000001712. Epub 2015 Jun 5. PubMed PMID: 26048028; PubMed Central PMCID: PMC4501939.

Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer's disease. Neuropsychologia. 2015 Jul;73:169-75. doi: 10.1016/j.neuropsychologia.2015.04.034. Epub 2015 May 19. PubMed PMID: 26002757; PubMed Central PMCID: PMC4479270.

Donovan NJ, Hsu DC, Dagley AS, Schultz AP, Amariglio RE, Mormino EC, Okereke OI, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults. J Alzheimers Dis. 2015;46(1):63-73. doi: 10.3233/JAD-142940. PubMed PMID: 25697700; PubMed Central PMCID: PMC4544638.

Huijbers W, Mormino EC, Schultz AP, Wigman S, Ward AM, Larvie M, Amariglio RE, Marshall GA, Rentz DM, Johnson KA, Sperling RA. Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression. Brain. 2015 Apr;138(Pt 4):1023-35. doi: 10.1093/brain/awv007. Epub 2015 Feb 11. PubMed PMID: 25678559; PubMed Central PMCID: PMC4438387.

Ge T, Nichols TE, Ghosh D, Mormino EC, Smoller JW, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative. A kernel machine method for detecting effects of interaction between multidimensional variable sets: an imaging genetics application. Neuroimage. 2015 Apr 1;109:505-514. doi: 10.1016/j.neuroimage.2015.01.029. Epub 2015 Jan 16. PubMed PMID: 25600633; PubMed Central PMCID: PMC4339421.

Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron. 2014 Nov 5;84(3):608-22. doi: 10.1016/j.neuron.2014.10.038. Epub 2014 Nov 5. Review. PubMed PMID: 25442939; PubMed Central PMCID: PMC4285623.

Hedden T, Schultz AP, Rieckmann A, Mormino EC, Johnson KA, Sperling RA, Buckner RL. Multiple Brain Markers are Linked to Age-Related Variation in Cognition. Cereb Cortex. 2016 Apr;26(4):1388-400. doi: 10.1093/cercor/bhu238. Epub 2014 Oct 14. PubMed PMID: 25316342; PubMed Central PMCID: PMC4785941.

Mormino EC, Betensky RA, Hedden T, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA. Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. 2014 Nov;71(11):1379-85. doi: 10.1001/jamaneurol.2014.2031. PubMed PMID: 25222039; PubMed Central PMCID: PMC4293023.

Ward AM, Mormino EC, Huijbers W, Schultz AP, Hedden T, Sperling RA. Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging. 2015 Jan;36(1):265-72. doi: 10.1016/j.neurobiolaging.2014.06.028. Epub 2014 Jul 3. PubMed PMID: 25113793; PubMed Central PMCID: PMC4268379.

Mormino EC. The relevance of beta-amyloid on markers of Alzheimer's disease in clinically normal individuals and factors that influence these associations. Neuropsychol Rev. 2014 Sep;24(3):300-12. doi: 10.1007/s11065-014-9267-4. Epub 2014 Aug 10. Review. PubMed PMID: 25108368; PubMed Central PMCID: PMC4313873.

Mormino EC, Betensky RA, Hedden T, Schultz AP, Ward A, Huijbers W, Rentz DM, Johnson KA, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing; Harvard Aging Brain
Study. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. 2014 May 20;82(20):1760-7. doi: 10.1212/WNL.0000000000000431. Epub 2014 Apr 18. PubMed PMID: 24748674; PubMed Central PMCID: PMC4035706.

Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. J Neurosci. 2014 Apr 9;34(15):5200-10. doi: 10.1523/JNEUROSCI.3579-13.2014. PubMed PMID: 24719099; PubMed Central PMCID: PMC3983800.

Vemuri P, Mormino EC. Cognitively stimulating activities to keep dementia at bay. Neurology. 2013 Jul 23;81(4):308-9. doi: 10.1212/WNL.0b013e31829c5f05. Epub 2013 Jul 3. PubMed PMID: 23825176.

Lehmann M, Madison CM, Ghosh PM, Seeley WW, Mormino E, Greicius MD, Gorno-Tempini ML, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD. Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11606-11. doi: 10.1073/pnas.1221536110. Epub 2013 Jun 24. PubMed PMID: 23798398; PubMed Central
PMCID: PMC3710820.

Wirth M, Oh H, Mormino EC, Markley C, Landau SM, Jagust WJ. The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly. Alzheimers Dement. 2013 Nov;9(6):687-698.e1. doi: 10.1016/j.jalz.2012.10.012. Epub 2013 Mar 7. PubMed PMID: 23474040; PubMed Central PMCID: PMC3823816.

Habeck C, Risacher S, Lee GJ, Glymour MM, Mormino E, Mukherjee S, Kim S, Nho K, DeCarli C, Saykin AJ, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. Relationship between baseline brain metabolism measured using [¹⁸F]FDG PET and
memory and executive function in prodromal and early Alzheimer's disease.
Brain Imaging Behav. 2012 Dec;6(4):568-83. doi: 10.1007/s11682-012-9208-x. PubMed PMID: 23179062; PubMed Central PMCID: PMC3532575.

Hedden T, Mormino EC, Amariglio RE, Younger AP, Schultz AP, Becker JA, Buckner RL, Johnson KA, Sperling RA, Rentz DM. Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. J Neurosci. 2012 Nov  14;32(46):16233-42. doi: 10.1523/JNEUROSCI.2462-12.2012. PubMed PMID: 23152607; PubMed Central PMCID: PMC3523110.

Nho K, Risacher SL, Crane PK, DeCarli C, Glymour MM, Habeck C, Kim S, Lee GJ, Mormino E, Mukherjee S, Shen L, West JD, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative--ADNI. Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer's disease. Brain Imaging Behav. 2012 Dec;6(4):551-67. doi: 10.1007/s11682-012-9203-2. PubMed PMID: 23070747; PubMed Central PMCID: PMC3532574.

Mukherjee S, Kim S, Gibbons LE, Nho K, Risacher SL, Glymour MM, Habeck C, Lee GJ, Mormino E, Ertekin-Taner N, Montine TJ, Decarli C, Saykin AJ, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. Genetic architecture of resilience of executive functioning. Brain Imaging Behav. 2012 Dec;6(4):621-33. doi: 10.1007/s11682-012-9184-1. PubMed PMID: 22711244; PubMed Central PMCID: PMC3607298.

Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ. Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals. Arch Neurol. 2012 Feb;69(2):223-9. doi: 10.1001/archneurol.2011.666. PubMed PMID: 22332189; PubMed Central PMCID: PMC4004919.

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O'Neil JP, Wilson RS, Jagust WJ. Association of lifetime cognitive engagement and low β-amyloid deposition. Arch Neurol. 2012 May;69(5):623-29. PubMed PMID: 22271235; PubMed Central PMCID: PMC3747737.

Jagust WJ, Mormino EC. Lifespan brain activity, β-amyloid, and Alzheimer's disease. Trends Cogn Sci. 2011 Nov;15(11):520-6. doi: 10.1016/j.tics.2011.09.004. Epub 2011 Oct 7. PubMed PMID: 21983147; PubMed Central PMCID: PMC3206968.

Mormino EC, Brandel MG, Madison CM, Marks S, Baker SL, Jagust WJ. Aβ Deposition in aging is associated with increases in brain activation during successful memory encoding. Cereb Cortex. 2012 Aug;22(8):1813-23. doi: 10.1093/cercor/bhr255. Epub 2011 Sep 23. PubMed PMID: 21945849; PubMed Central PMCID: PMC3388896.

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks S, Baker SL, Jagust WJ. Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant. Neuroimage. 2012 Jan 16;59(2):1152-60. doi: 10.1016/j.neuroimage.2011.07.098. Epub 2011 Aug 22. PubMed PMID: 21884802; PubMed Central PMCID: PMC3230690.

Mormino EC, Smiljic A, Hayenga AO, Onami SH, Greicius MD, Rabinovici GD, Janabi M, Baker SL, Yen IV, Madison CM, Miller BL, Jagust WJ. Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging. Cereb Cortex. 2011 Oct;21(10):2399-407. doi: 10.1093/cercor/bhr025. Epub 2011 Mar 7. PubMed PMID: 21383234; PubMed Central
PMCID: PMC3169663.

Oh H, Mormino EC, Madison C, Hayenga A, Smiljic A, Jagust WJ. β-Amyloid affects frontal and posterior brain networks in normal aging. Neuroimage. 2011 Feb 1;54(3):1887-95. doi: 10.1016/j.neuroimage.2010.10.027. Epub 2010 Oct 18. PubMed PMID: 20965254; PubMed Central PMCID: PMC3038633.

Furst AJ, Mormino EC. A BOLD move: clinical application of fMRI in aging. Neurology. 2010 Jun 15;74(24):1940-1. doi: 10.1212/WNL.0b013e3181e533f8. Epub 2010 May 19. PubMed PMID: 20484684.

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O'Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ. Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Brain. 2010 Feb;133(Pt 2):512-28. doi: 10.1093/brain/awp326. Epub 2010 Jan 15. PubMed PMID: 20080878; PubMed Central PMCID: PMC2858015.

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, O'Neil JP, Lal RA, Dronkers NF, Miller BL, Gorno-Tempini ML. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008 Oct;64(4):388-401. doi: 10.1002/ana.21451. PubMed PMID: 18991338; PubMed Central PMCID: PMC2648510.

Daley M, Levitt J, Siddarth P, Mormino E, Hojatkashani C, Gurbani S, Shields WD, Sankar R, Toga A, Caplan R. Frontal and temporal volumes in children with epilepsy. Epilepsy Behav. 2007 May;10(3):470-6. Epub 2007 Mar 26. PubMed PMID: 17382595.

Daley M, Ott D, Blanton R, Siddarth P, Levitt J, Mormino E, Hojatkashani C, Tenorio R, Gurbani S, Shields WD, Sankar R, Toga A, Caplan R. Hippocampal volume in childhood complex partial seizures. Epilepsy Res. 2006 Nov;72(1):57-66. Epub 2006 Aug 22. PubMed PMID: 16930947.

Blanton RE, Levitt JG, Peterson JR, Fadale D, Sporty ML, Lee M, To D, Mormino EC, Thompson PM, McCracken JT, Toga AW. Gender differences in the left inferior frontal gyrus in normal children. Neuroimage. 2004 Jun;22(2):626-36. PubMed PMID: 15193591.