Spring 2016 BioEngineering 229/Radiology 222C

Instructors

Assistant Professor (Research) of Radiology (General Radiology)
(650) 725-4182
Professor of Pediatrics (Neonatology), Emeritus
Professor of Radiology (General Radiology)
Sr Res Scientist-Basic Life, Rad/Molecular Imaging Program at Stanford
Assistant Professor of Radiation Oncology (Radiation Physics)
(650) 724-9829
Professor of Otolaryngology-Head and Neck Surgery and of Radiology (Molecular Imaging Program at Stanford)
(650) 723-2967

Course Logistics


Classes: Mondays and Fridays 9:30-11:20 AM
M114 Alway Building
Reference
Materials:


At Lane Library

Molecular Imaging: Principles and Practice
Weissleder R, Ross BD, Rehemtulla A, Gambhir SS
2010 People's Medical Publishing House

Exams: Midterm and final exams consist of a proposal review (midterm) and a written proposal (final)
Proposal to review
Critique Template
Grading: Class participation (30%)
Midterm exam—review a proposal (30%)
Final exam—write a proposal (40%)

Course Syllabus


Week Monday Instructor Friday Instructor
1 3/28

Parcels of molecular data in cellular communication: imaging exosome function

C. Contag

 Lecture notes

 Kanada M. Differential fates of biomolecules delivered to target cells via extracellular vesicles. PNAS 2015;112(12):E1433-42.
 Kanada M. Signaling by Extracellular Vesicles Advances Cancer Hallmarks.Trends in Cancer. 2016;2(2):84-94.

4/1

Parcels of molecular data in cellular communication: imaging exosome function

C. Contag

 Lecture notes

2 4/4

Multimodality Imaging of Glutamate for Cancer Diagnosis and Therapy

E. Mittra

 Lecture notes

 Choi C. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas. Nat Med. 2012;18(4):624-30
 Hensley C. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest. 2013 Sep;123(9):3678-84.
 Keshari K.Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imagings.PNAS 2011 Nov 15;108(46):18606-11.
 Koglin N. Specific PET Imaging of xC- Transporter Activity Using a 18 F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism. Clin Cancer Res. 2011 Sep 15;17(18):6000-11.
 Takeuchi S. Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas. Neurosurgery. 2013 Jan;72(1):33-41.

4/8

Multimodality Imaging of Glutamate for Cancer Diagnosis and Therapy

E. Mittra

 Lecture notes

3 4/11

Neural Dynamics and Glymphatics (Stains and Drains in Brains) - Is It All a Wash?

M. Moseley

 Lecture notes

4/15

Neural Dynamics and Glymphatics (Stains and Drains in Brains) - Is It All a Wash?

M. Moseley

 Lecture notes

4 4/18

Imaging agents in robotic surgery

J. Sorger

 Lecture notes

 Hu JC. Temporal trends in radical prostatectomy complications from 1991 to 1998. J Urol. 2003 Apr;169(4):1443-8.
 Holland CM. Radical hysterectomy. Best Pract Res Clin Obstet Gynaecol. 2005 Jun;19(3):387-401.
 Lanfranco AR. Robotic surgery: a current perspective.Ann Surg. 2004 Jan;239(1):14-21.
 Ramirez D. Robotic-assisted laparoscopic prostatectomy: An update on functional and oncologic outcomes, techniques, and advancements in technology. J Surg Oncol. 2015 Dec;112(7):746-52.
 Sinha R. Robotic surgery in gynecology. J Minim Access Surg. 2015 Jan-Mar;11(1):50-9.
 Daskalaki D.Fluorescence in robotic surgery. J Surg Oncol. 2015 Sep;112(3):250-6.

4/22

Imaging agents in robotic surgery

J. Sorger
5 4/25

Image-guided surgery

E. Rosenthal

 Lecture notes

 de Boer E. A standardized light-emitting diode device for photoimmunotherapy. JNM 2014 Nov;55(11):1893-8.
 Mitsunaga M. Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate. Bioconjug Chem. 2012 Mar 21;23(3):604-9.
 Sato K.Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor. Mol Oncol. 2014 May;8(3):620-32.

4/29

Image-guided surgery

E. Rosenthal

 

Midterm Exam Materials

Proposal to review
Critique Template

 

 

6 5/2

Nanoprobes for diagnosis and imaging

S. Park

 Lecture notes

 James M. A molecular imaging primer: modalities, imaging agents, and applications. Physiol Rev. 2012 Apr;92(2):897-965.

5/6

Nanoprobes for diagnosis and imaging

S. Park
7 5/9

Follow that cell! New frontiers in cell tracking

G. Pratx

 Lecture notes

 Kircher MF.Noninvasive cell-tracking methods. Nat Rev Clin Oncol. 2011 Sep 27;8(11):677-88.
 Rogers WJ.Technology insight: in vivo cell tracking by use of MRI. Nat Clin Pract Cardiovasc Med. 2006 Oct;3(10):554-62.
 Zhang SJ.Comparison of imaging techniques for tracking cardiac stem cell therapy. JNM. 2007 Dec;48(12):1916-9.

5/13

Follow that cell! New frontiers in cell tracking

G. Pratx
8 5/16

Clinical Photoacoustic Imaging: Hype or Hope?

R. Kothapalli

 Garcia-Uribe A. Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer. Sci Rep. 2015 Oct 29;5:15748.
 Stoffels I. Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med. 2015 Dec 9;7(317):317ra199.
 Zackrisson S. Light in and sound out: emerging translational strategies for photoacoustic imaging. Cancer Res. 2014 Feb 15;74(4):979-1004.

5/20

Clinical Photoacoustic Imaging: Hype or Hope?

R. Kothapalli
9 5/23

 

Novel PET-MR Imaging Strategies for Studying Living Subjects

F. Chin

 

 Lecture notes

 de Galiza Barbosa F.Multi-technique hybrid imaging in PET/CT and PET/MR: what does the future hold? Clin Radiol. 2016 Apr 21. pii: S0009-9260(16)30001-0. 
 Barthel H. PET/MR in dementia and other neurodegenerative diseases.Semin Nucl Med. 2015 May;45(3):224-33. 
 Fraum TJ. PET/MRI: Emerging Clinical Applications in Oncology. Acad Radiol. 2016 Feb;23(2):220-36. 
 Gaertner FC. PET/MR: a paradigm shift. Cancer Imaging. 2013 Feb 27;13:36-52. 
 Disselhorst JA.Principles of PET/MR Imaging.JNM 2014 May 12;55(Supplement 2):2S-10S. 
 Queiroz MA. PET/MR in cancers of the head and neck. Semin Nucl Med. 2015 May;45(3):248-65. 
 Torigian DA. PET/MR imaging: technical aspects and potential clinical applications.Radiology. 2013 Apr;267(1):26-44.

5/27

 

Novel PET-MR Imaging Strategies for Studying Living Subjects

F. Chin

 

 Ganji A. Aptamers: new arrows to target dendritic cells. J Drug Target. 2016;24(1):1-12. 
 Gijs M. Aptamers as radiopharmaceuticals for nuclear imaging and therapy.Nucl Med Biol. 2016 Apr;43(4):253-71. 
 Oh SS. Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells. J Am Chem Soc. 2014 Oct 22;136(42):15010-5. 
 Pei X. Clinical applications of nucleic acid aptamers in cancer (Review).Mol Clin Oncol. 2014 May;2(3):341-348. 
 Sandiford L. The Use of Contrast Agents in Clinical and Preclinical PET-MR Imaging. PET Clin. 2016 Apr;11(2):119-28. 
 Sun H.Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy. Mol Ther Nucleic Acids. 2014 Aug 5;3:e182. 
 Wang J. Particle display: a quantitative screening method for generating high-affinity aptamers. Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. 
 Yüce M. Trends in aptamer selection methods and applications. Analyst. 2015 Aug 21;140(16):5379-99.

10 5/30 Holiday
Final exams June 3-8, 2016