Fall 2016 BioEngineering 222/Radiology 222

Multimodality Molecular imaging in Living Subjects

Instructors

Assistant Professor of Radiology (Pediatric Radiology)
Assistant Professor of Structural Biology and, by courtesy, of Electrical Engineering
Associate Professor of Radiation Oncology (Radiation Physics) and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
(650) 723-5591
Affiliate, Rad/Radiological Sciences Laboratory
Professor of Radiology (Molecular Imaging Program at Stanford/Nuclear Medicine) and, by courtesy, of Physics, of Electrical Engineering and of Bioengineering
Professor of Radiology (General Radiology)
Assistant Professor of Radiation Oncology (Radiation Physics)
(650) 724-9829
Instructor, Rad/Body Imaging
Jacob Haimson Professor and Professor, by courtesy, of Electrical Engineering
(650) 498-7896

Course Logistics


Classes: Mondays and Fridays 8:30-10:20 AM
CCSR4107
Reference
Materials:
 

Molecular Imaging Primer
Gambhir SS
2013 Apple Self-Publishing

 


Molecular Imaging: Principles and Practice
Weissleder R, Ross BD, Rehemtulla A, Gambhir SS
2010 People's Medical Publishing House

On reserve at
Lane Library


Molecular Imaging with Reporter Genes
Edited by Gambhir SS & Yaghoubi S
2010 Cambridge University Press

On reserve at
Lane Library




Grading: 20% class participation,
40% midterm,
40% final exam
Exams: November 4, 2016 Mid-term Exam
December 12, 2016 - Final Exam
8:30- 11:30am
Center for Clinical Science Research RSRC 4107

Course Syllabus


Week Monday Instructor Friday Instructor
1 9/26

Tours of Small Animal Imaging Facility and Molecular Imaging Clinic

C. Levin
9/30

Radiation/Radionuclide Physics

C. Levin

Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

2 10/3

Tomographic Image Reconstruction

G. Pratx

Lecture notes

Physics in Nuclear Medicine. Eds. Cherry, Sorenson, Phelps. Saunders, 4 edition, 2012. Chapter 16

10/7

Positron Emission Tomography (PET)

C. Levin

Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10

3 10/10

Single Photon Emission Computed Tomography (SPECT)

C. Levin

Lecture notes

Molecular Imaging: Principles and Practice
Chapter 7

Molecular Imaging with Reporter Genes
Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8

10/14

 

Ultrasound Imaging Physics

J. Dahl

 Lecture notes

Anderson ME. A seminar on k-space applied to medical ultrasound. 1997. Chapters 1 & 2.

Diagnostic Ultrasound Imaging: Inside Out.. Academic Press, 2013. Chapter 14 (free to Stanford students)

Dahl J. Ultrasound Beam Forming and Image Formation. RSNA 2005:63-71.

4 10/17

Molecular Ultrasound

A. Kaffas

 Lecture notes

10/21

X-ray Computed Tomography (CT)

S. Hsieh

 Lecture notes

5 10/24

Visible Light Optics

M. Mandella

 Lecture notes

Going deeper than microscopy: the optical imaging frontier in biology. Nature Methods 2010;7(8):603-614.

Lohmann AW. Scaling laws for lens systems. Appl Opt. 1989 Dec 1;28(23):4996-8.

10/28

Fluorescence Imaging & Tomography

E. Graves

 Lecture notes

Graves EE. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med. Phys. 2003;30(5):901-911.

Ntziachristos V. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett. 2001 Jun 15;26(12):893-5.

Patterson MS. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Appl Opt. 1989 Jun 15;28(12):2331-6d.

5 10/31

Bioluminescence Imaging & Tomography

E. Graves

 Lecture notes

Contag C. It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. J Magn Reson Imaging. 2002 Oct;16(4):378-87.

Kuo C. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. J Biomed Optics 2007;12(2): 024007.

11/4

Mid-Term Exam

5 11/7

Molecular & Cellular MRI

M. Moseley

 Lecture notes

11/11

Nuclear Magnetic Resonance (NMR) and MR Imaging Physics

M. Moseley

 Lecture notes

6 11/14

Optical Fluorescence Endoscopy

M. Mandella

 Lecture notes

Brady DJ. Multiscale lens design. Opt Express. 2009 Jun 22;17(13):10659-74.

Ghosh KK. Miniaturized integration of a fluorescence microscope. Nat Methods. 2011 Sep 11;8(10):871-8.

Liu J. Point-of-care pathology with miniature microscopes. Anal Cell Pathol (Amst). 2011;34(3):81-98.

Völkel R. Miniaturized imaging systems. Microelectronic Engineering 2003;67–68:461–472.

11/18

Photoacoustic Tomography (PAT)

A. de la Zerda

 Lecture notes

Thanksgiving Holiday
No Lectures

7 11/28

Raman Scatter Imaging

C. Zavaleta

Lecture notes

Austin LA.Raman technologies in cancer diagnostics. Analyst 2015.

Raman CV. A New Type of Seconday Radiation.Nature 1928.

Zavaleta C. Raman's "Effect" on Molecular Imaging. JNM 2011;52(11):1839-1844.

12/2

Magnetic Partical Imaging

S. Conolly

Lecture notes

Magnetic Particle Imaging

Gleich B. Tomographic imaging using the nonlinear response of magnetic particles. Nature. 2005 Jun 30;435(7046):1214-7.

Lu K. Linearity and shift invariance for quantitative magnetic particle imaging. IEEE Trans Med Imaging. 2013 Sep;32(9):1565-75.

Zheng B. Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics. 2016 Jan 1;6(3):291-301.

8 12/5

X-ray Fluorescence Tomography

L. Xing

Lecture notes

12/9

Multimodality Molecular Imaging Technology Currently in the Clinic: PET/CT and PET/MR

C. Levin

 Lecture notes

Molecular Imaging: Principles and PracticeChapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

10 12/12

Final Exam

8:30- 11:30am
Center for Clinical Science Research RSRC 4107