Bioengineering/Radiology 222A Fall 2012
Multi-modality Molecular Imaging in Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM, LKSC-LK306

Week Monday Instructor Friday Instructor
1 9/24

Introduction to Molecular Imaging

C. Contag
9/28

Radionuclide Physics

C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

2 10/1

Tomographic Image Reconstruction

C. Levin
10/5

Positron Emission Tomography (PET)

C. Levin
3 10/8

Single Photon Emission Computed Tomography (SPECT)

C. Levin
10/12

Multi-modality Molecular Imaging Systems (PET/CT and PET/MRI)

C. Levin
Lecture notes (75MB)

Molecular Imaging: Principles and Practice Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

4 10/15

Tissue optics

E. Graves
10/19

Fluorescence Imaging

E. Graves
Lecture notes

Patterson MS, et al. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Applied Opt 1989;28(12):2331-36.

Graves EE, et al. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Physics 2003;30(5):901-11.

Ntziachristos V, et al. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett 2001;26(12):893-5.

5 10/22

Bioluminescence Imaging

E. Graves
Lecture notes

Contag C, et al. It's Not Just About Anatomy: In Vivo Bioluminescence Imaging as an Eyepiece into Biology. J MRI 2002;16:378-387.

Kuo C, et al. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. Biomed Opt 2007;12(2).

10/26

Raman Scatter Imaging

C. Zavaleta
Lecture notes

Zavaleta C, et al. Raman's "Effect" on Molecular Imaging. JNM 2011;52-(11):1839-1844.

Raman CV, et al. A New Type of Seconday Radiation. Nature 1928.

6 10/29 MID-TERM EXAM 11/2

Ultrasound Imaging

K. Butts Pauly
Lecture notes

Hynynen K. MRIgHIFU: a tool for image-guided therapeutics. JMRI 2011;34(3):482-93.

7 11/5

Photoacoustic tomography

A. de la Zerda
Lecture notes
11/9

Nuclear Magnetic Resonance (NMR) Physics

M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

8 11/12

Magnetic Resonance Imaging (MRI)

M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

11/16

Strategies for Molecular Imaging with MRI

M. Moseley
Lecture notes
Thanksgiving recess (11/19-11/23). No class.
9 11/26

Molecular Imaging of the Brain

M. James
Lecture notes

Price JC. Molecular brain imaging in the multimodality era. J Cereb Blood Flow Metab. 2012;32(7):1377-92.

Xi W. Molecular imaging in neuroscience research with small-animal PET in rodents. Neurosci Res. 2011;70(2):133-43.

11/30

Molecular Imaging of Cardiac Stem Cell Therapy

P. Nguyen
Lecture notes

Chen IY. Cardiovascular Molecular Imaging: Focus on Clinical Translation. Circ. 2011;123(4):425–443.

Nguyen PK. Imaging: Guiding the Clinical Translation of Cardiac Stem Cell Therapy. Circ Res. 2011;109(8):962–979.

Additional reading material

10 12/3

Molecular Imaging of Pain

S. Biswal
Lecture notes
12/7

Molecular Imaging of Cancer for Radiation Therapy

L. Xing
Lecture notes
FINAL EXAM: LKSC-LK306
December 13, 2012 at 8:30-11:30am
11 TBD Tours of Small Animal Imaging Facility and Molecular Imaging Clinic
C. Levin