Developing New Approaches to Treat Heart Disease
The Mercola laboratory is focused on developing new therapies for cardiovascular disease. Cardiovascular disease, including heart failure, remains a major cause of human mortality worldwide despite advances in clinical management. Our research combines in vitro disease models using cardiovascular cells generated from induced pluripotent stem cells (iPSCs) with high throughput screening to define disease mechanisms, identify drug targets and develop drug leads. Since iPSCs are derived from patient biopsies, these cells make it possible to visualize the effect of individual patient genetics on disease, and develop new and effective drugs.
Dr. Mercola is Professor of Cardiovascular Medicine and a member of the Stanford Cardiovascular Institute. He trained at the Dana-Farber Cancer Institute in Boston and Harvard Medical School. He was on the faculty at Harvard Medical School and then at the Sanford-Burnham-Prebys Medical Discovery Institute and the Department of Bioengineering at the University of California, San Diego prior to relocating to Stanford in 2015. The laboratory is funded by research grants from the National Institutes of Health (NIH), the California Institute for Regenerative Medicine and the Fondation Leducq.
Human cardiomyocytes derived from induced pluripotent stem cells (iPSCs) made from a healthy individual.
- Bruyneel AAN., et al. (2018). A novel inhibitor targets both Wnt signaling and ATM/p53 in colorectal cancer. Cancer Research.
- Jeong, D., et al. (2018). Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function. Curr Cardiol Rep., 25(7), 57.
- Diez-Cuñado, M., et al. (2018). miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway. Cell Reports. 23(7), 2168-2174.
- Jeong, D., et al. (2018). miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure. Molecular Therapy, 26(3), 718-729.
- McKeithan, W., et al. (2017). An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-derived Cardiomyocytes. Fron. Physiol. 10.3389/2017.00766.
- Cunningham, T., et al. (2017). Id genes are essential for early heart formation. Genes & Development 31:1-14.
- Sharma, A., et al. (2017). High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med 9, 377.