The 32nd Annual Stanford Medical Student Research Symposium will be held:
May 7, 2015
3 - 6 p.m.
This Symposium is less structured and formal than other research conferences in order to encourage as many medical students as possible to communicate the research part of their educational program that is often not shared with their peers. Poster presentations are required by each student (3-6pm).
Research can be in progress or finished; must have a Stanford faculty advisor; and may be a part of an outside fellowship (e.g. Howard Hughes, Sarnoff, etc), internal fellowship (Medical Scholars), research assistantship, MD/PhD program, or Directed Research.
Research presented at this Symposium can be presented and published elsewhere.
Medical Student Research Symposium - Applications will open on March 2, 2015 and the deadline is noon 4/3/15!
Interested students will submit their Abstract and cover sheet online. More info will be e-mailed once the abstract is received.
Medical Student Research Abstract Preparation
- Title – List in BOLD CAPS.
- Authors – List the first name, middle initial, and last name of all authors. List your name in bold and indicate the Stanford faculty advisor with whom you conducted research by underlining his/her name.
- Departments – List all Departments represented
- Arrangement – Use three paragraphs. In general, the paragraph content should be:
First paragraph: general statement of the research topic, including two-to-three sentence background, objective, and approach (the methods can be in the second paragraph also)
Second paragraph: research findings to date
Third paragraph: conclusion, implications, further studies
- Graphics – Do not use charts, diagrams or tables unless essential.
- Greek letters – Use symbols (α) to designate or spell out (alpha).
- References – In general try to avoid citing references in your abstract.
- Abbreviations/acronyms – It is necessary to define all initially except those commonly used such as DNA, cAMP.
- Length – Stay under 300 words and/or one page (using 12pt Aria font).
- Funding – Acknowledge funding source in separate final sentence in italics (e.g., Funding provided by the Stanford Medical Scholars Fellowship Program).
THE ROLE OF DENSE-CORE VESICLES IN SYNAPSE FORMATION
Susanne E. Ahmari, JoAnn Buchanan, and Stephen J Smith. Department of Molecular and Cellular Physiology
Fast neurotransmitter secretion occurs at specialized presynaptic active zones composed of a conspicuous plasma membrane specialization and a cluster of synaptic vesicles. Little is known about how such active zones are assembled during central nervous system (CNS) synaptogenesis. Using low-density hippocampal neuronal cultures, we have developed a system in which synapse formation can be monitored in real time.
In past experiments, we have used VAMP-GFP, a fluorescently tagged protein which serves as a marker of synaptic vesicles, to monitor synapse formation. We have demonstrated that punctate clusters of VAMP-GFP, which we call transport packets, quickly accumulate at sites of new inter-neuronal contact (Ahmari et al, Nature Neuroscience, 2000). Interestingly, transport packets often contain many other molecular components of the presynaptic active zone. This gives support to the idea that many or all of the cytoplasmic, plasma membrane, and vesicular components of the active zone may be united early in their biogenesis and sorting pathways, long before arrival at the nascent synapse.
Using retrospective electron microscopy, we analyzed the vesicular components of the transport packets. To our surprise, many dense-core vesicles were observed. Coupled with evidence from other labs (Zhao et al, Neuron, 2000), our results suggest that dense-core vesicles may specifically play a role in synapse formation. We have used a dense-core vesicle marker, ANP-GFP, in combination with VAMP-DsRed, to determine if dense-core vesicles and synaptic vesicles form two distinct populations with separate neuronal functions. Preliminary results indicate that dense core vesicles and transport packets comprise separate but overlapping populations. Further studies will examine functional implications of this finding.
Funding provided by the Stanford Medical Scholars Fellowship Program.
Medical Student Research Symposium Presentations
To be eligible for the cash prizes, all Symposium participants must present a poster representing their research (3-6pm).
In addition, some participants may be asked to make oral presentations of their projects at a Donor Appreciation event(s) TBA.