Highlighted Faculty Publications

Brian Kobilka and Georgios Skiniotis

Maeda S, Qu Q, Roberston MJ, Skiniotis G, Kobilka BK (2019). Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science. May 10;364(6440):552-557.

Thomas Südhof

Dai J, Aoto J, Südhof TC (2019). Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. Apr 9. pii: S0896-6273(19)30295-8.

Thomas Südhof

Sando R, Jiang X, Südhof TC (2019). Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. Science. Feb 22;363(6429).

Axel Brunger

White KI, Zhao M, Choi UB, Pfuetzner RA, Brunger AT (2018). Structural principles of SNARE complex recognition by the AAA+ protein NSFeLife 7, e38888. 10.7554/eLife.38888.

Rich Lewis

Yen M, Lewis RS (2018). Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.  J Gen Physiol. Oct 1;150(10):1373-1385.

Merritt Maduke

Koster AK, Wood CAP, Thomas-Tan R, Chavan TS, Almqvist J et al (2018).  A selective class of inhibitors for the CLC-Ka chloride ion channel. PNAS. May 22;115(21):E4900-E4909.

Chris Garcia

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, et al (2017). Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science. 355(6331):1320-1324.

Merritt Maduke

Prieto ML, Firouzi K, Khuri-Yakub BT, Maduke M (2017). Activation of Piezo1 but Not NaV1.2 Channels by Ultrasound at 43 MHz.  Ultrasound Med Biol. Jun;44(6):1217-1232.

 

William Weis

Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR (2017). Vinculin forms a directionally asymmetric catch bond with F-actin.  Science. Aug 18;357(6352):703-706.

Liang Feng

Tao Y, Cheung L, Shuo L, Eom J, Chen L, et al (2015). Structure of a eukaryotic SWEET transporter in a homotrimeric complex. Nature. 527:259-263.

Miriam Goodman

Krieg M , Dunn A, Goodman MB, (2014). Mechanical control of the sense of touch by b spectrin. Nat Cell Biol. 16:224–233.

Brian Kobilka and Georgios Skiniotis

Koehl A, Hu H, Feng D, Sun B, Zhang Y et al (2019). Structural insights into the activation of metabotropic glutamate receptors. Nature. Mar;567(7747):E10.

Brian Kobilka and Georgios Skiniotis

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD et al (2019). Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell. Jan 24;176(3):448-458.

Lucy O'Brien

Martin JL, Sanders EN, Moreno-Roman P, Jaramillo Koyama LA, Balachandra S et al (2018). Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss. eLife. Nov 14;7. pii: e36248.

Chris Garcia

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, et al (2018).  Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell. Jul 26;174(3):672-687.

Axel Brunger

Zhou Q, Zhou P, Wang AL, Wu D, Zhao M, et al (2017). The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. 548(7668):420-425.

Lucy O'Brien

Liang J, Balachandra S, Ngo S and O'Brien LE (2017). Feedback regulation of steady-state epithelial turnover and organ size. Nature. 548:588-591.

Miriam Goodman

Krieg M, Stühmer J, Cueva JG, Fetter R, Spilker K, et al (2017). Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling. eLife. 6. pii: e20172. doi: 10.7554/eLife.20172.

Rich Lewis

Yen M, Lokteva LA, Lewis RS (2016). Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.  Biophys J. Nov 1;111(9):1897-1907.  

Steve Chu

Liang Z, Zheng G, Liu C, Liu N, Li W, et al (2015). Polymer nanofiber-guided uniform lithium deposition for battery electrodes. Nano Lett.

William Weis

Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, et al (2014). Cell adhesion. The minimla cadherin-catenin complex binds to actin filaments under force. Science. 346:1254211.

Liang Feng

Xu Y, Tao Y, Cheung LS, Fan C, Chen LQ, et al (2014). Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature. 515:448-52.