Transdisciplinary Initiatives Program (TIP)

"Autism is a neurodevelopmental disorder that affects nearly 1 in 54 children and constitutes a significant concern for public health, yet the etiology of the disorder is not known. Funding from MCHRI has allowed us to investigate, for the first time, neurobiological markers that detect autism and predict severity of autism symptoms in male and female children in novel quantitative ways that were not previously possible. Our studies will transform our understanding of brain mechanisms underlying behavioral impairments in childhood autism and contribute significantly towards the development of more effective and precise diagnostic and treatment strategies for autism."

Kaustubh Supekar, PhD
The Taube Family Endowed Transdisciplinary Investigator for Maternal Child Health
Clinical Assistant Professor, Psychiatry and Behavioral Sciences


2020 Awards

Project Title: Modeling the Earliest Developmental Stages of Human Cardiac Vascularization using Pluripotent Stem Cells
PI: Daniel Bernstein, MD, Professor, School of Medicine (Pediatrics - Cardiology)
Co-Is: Oscar J. Abilez, MD, PhD, Instructor, School of Medicine (Medicine - Cardiovascular Medicine); Ellen Kuhl, MS, PhD, Professor, School of Engineering (Mechanical Engineering)

Project Title: Lysosomal Dysfunction in Childhood-Onset Neurodegeneration: Biochemical Profiling and Genetic Correction of Progranulin Deficiency
PI: Natalia Gomez-Ospina, MD, PhD, Assistant Professor, School of Medicine (Pediatrics - Medical Genetics and Stem Cell Transplantation & Regenerative Medicine)
Co-I: Monther Abu-Remaileh, Assistant Professor, School of Engineering (Chemical Engineering) 

Project Title: Deciphering the Cellular and Molecular Basis of Congenital Arteriovenous Malformations Using Stem Cell-Derived Artery and Vein Endothelial Cells
PI: Kyle M. Loh, PhD, Assistant Professor, School of Humanities & Sciences (Development Biology)
Co-Is: Kristy Red-Horse,Associate Professor, PhD, School of Humanities & Sciences (Biology); Marlene Rabinovitch, MD, Professor, School of Medicine (Pediatrics - Cardiology); Lay Teng Ang, PhD, Instructor, Institute for Stem Cell Biology and Regenerative Medicine  

Project Title: Discovering Adolescents' Smartphone Food Environments
PI: Thomas N. Robinson, MPH, MD, Professor, Pediatrics (General Pediatrics)
Co-Is: Kristy Red-Horse, Associate Professor, PhD, School of Humanities & Sciences (Biology); Marlene Rabinovitch, MD, Professor, School of Medicine (Pediatrics - Cardiology); Lay Teng Ang, PhD, Instructor, Institute for Stem Cell Biology and Regenerative Medicine 

Project Title: Identifying Neurobiological Markers of Autism by Leveraging "Big Data" and Using Deep Learning
PI: Kaustubh Supekar, PhD, The Taube Family Endowed Transdisciplinary Investigator for Maternal Child Health; Clinical Assistant Professor, School of Medicine (Psychiatry & Behavioral Sciences)
Co-I: Vinod Menon, PhD, Professor, School of Medicine (Psychiatry & Behavioral Sciences); Tengyu Ma, PhD, Assistant Professor, School of Engineering (Computer Science) & School of Humanities & Sciences (Statistics)

Past Awards