Our Current Research
Bill and Melinda Gates Foundation
The Maldonado Group received a grant from the Bill & Melinda Gates Foundation for a 2.5 year study investigating the dynamics of oral poliovirus vaccine (OPV) household and community transmission in 3 communities in Orizaba, Veracruz, Mexico. Mexico provides a unique environment to study OPV transmission. Currently, Mexican children receive inactivated poliovirus vaccine (IPV) in their primary vaccination series. In addition, children ≤5 years old who have received at least 2 doses of IPV are eligible to receive OPV during biannual National Immunization Weeks. Our study will specifically assess the impact of different OPV vaccination rates during the February 2015 National Immunization Week on intra- and inter-household transmission of OPV. The outcome of this project will inform public policy decision-making regarding OPV cessation and the polio end-game.
In the News
"Emerging form of poliovirus threatens hopes for eradication." Stanford Medicine News. April 3, 2015
For more information, contact Clea Sarnquist.
In collaboration with Ujamaa Africa and No Means No Worldwide
Sexual assault is a major cause of injury, unplanned pregnancy, HIV infection, and mental health issues worldwide. In parts of sub-Saharan Africa, sexual assault has reached epidemic proportions. Our team is involved in studies evaluating interventions to reduce GBV in Kenya. These include: (1) researching the efficacy of an empowerment and self-defense intervention for adolescent girls in to decrease the incidence of sexual assault and harassment in Nairobi’s large informal settlements and (2) evaluating a micro-finance intervention aimed at improving economic conditions and decreasing GBV among survivors of intimate partner violence.
The group received a grant from the Medical Research Council of South Africa to conduct a cluster-randomized trial of this intervention among young adolescent girls.
In the News
Our previous evalution of the curriculum: "Empowerment program greatly decreases incidence of rape, study finds." Stanford Medicine News. April 13, 2014.
For more information on this project, please contact Clea Sarnquist.
Evaluation of mobile technology platform to enhance evidence based practice for the treatment & epidemiological surveillance for diarrheal diseases in Bangladesh
Case fatality rates from diarrhoeal disease, including cholera, can rise above the WHO accepted threshold of 1% in both endemic and non-endemic settings, even in regions of Bangladesh. One challenge to reduce the morbidity and mortality from diarrhoeal diseases is to develop desired and scalable tools to improve decision support, and to be able to more easily report diarrhoeal cases. We hypothesize that a mobile phone based decision support tool will improve adherence to management guidelines for fluid resuscitation compared to existing methods.
Our objective is to determine if adherence to rehydration guidelines improves with the use of a mobile technology decision-support platform. To address this objective and test the hypothesis, a pilot study followed by a cluster randomized controlled trial will be conducted in the District of Netrokona, Bangladesh.
The PI of this grant is, Dr. Eric Nelson, the first Global Health fellow and Instructor, who is mentored by Dr. Maldonado.
In the News
"Reporting and treating cholera: soon there coule be an app for that." Stanford Medicine Scope Blog, May 11, 2015.
For more information, contact Dr. Eric Nelson.
Preventing violence against girls
As many as a million people live without basic services such as water, sanitation, and electricity in the informal settlements, or slums, in and around Nairobi, Kenya. The areas are also home to high rates of violence, especially against women. The Maldonado lab is working with PI, Dr. Michael Baiocchi, to evaluate interventions to empower girls and boys to prevent such violence.