Figure 1: Hierarchical Model of Normal Hematopoiesis and Human Acute Myeloid Leukemia
(A) Self-renewing HSC reside at the top of the hierarchy, giving rise to multipotent progenitors that in turn give rise to lineage-committed progenitors that eventually produce terminally differentiated blood cells. (B) AML is organized as a hierarchy initiated by self-renewing leukemia stem cells that give rise to leukemic progenitors, which in turn give rise to the leukemia blasts.