Characterization and Targeting of Leukemia Stem Cells in Human Hematologic Malignancies

The Majeti lab focuses on the molecular/genomic characterization and therapeutic targeting of leukemia stem cells in human hematologic malignancies, particularly acute myeloid leukemia (AML). In parallel, the lab also investigates normal human hematopoiesis and hematopoietic stem cells. Our lab uses experimental hematology methods, stem cell assays, genome editing, and bioinformatics to define and investigate drivers of leukemia stem cell behavior. As part of these studies, we have led the development and application of robust xenotransplantation assays for both normal and malignant human hematopoietic cells. A major focus of the lab is the investigation of pre-leukemic hematopoietic stem cells in human AML.

About Us

Ravi Majeti, Principal Investigator

A.B. Biochemical Sciences, Harvard University
M.D. University of California, San Francisco
Ph.D. University of California, San Francisco
Associate Professor of Medicine, Division of Hematology
Member, Institute for Stem Cell Biology and Regenerative Medicine
Member, Cancer Institute