Laboratory of Signaling Dynamics

Principal Investigator

Michael Z. Lin, MD, PhD

Michael Z. Lin received an A.B. summa cum laude in Biochemistry from Harvard, an M.D. from UCLA, and a Ph.D. from Harvard Medical School. After training in biochemistry and neurobiology as a PhD student with Michael Greenberg at Harvard Medical School, Dr. Lin performed postdoctoral research in fluorescent protein engineering with Chemistry Nobel Laureate Roger Y. Tsien at UCSD. Dr. Lin is a recipient of a Burroughs Wellcome Career Award for Medical Scientists, a Rita Allen Scholar Award, a Damon Runyon-Rachleff Innovation Award, and a NIH Pioneer Award.


The Lin Lab applies biochemical knowledge and engineering principles to the development of protein-based tools for molecular imaging, optogenetic studies, and gene therapy. Topics of investigation include fluorescent protein structures and biophysics, fluorescentprotein-based biosensors, spatiotemporal analysis of protein translation pathways, chemical control of protein translation, and light-responsive proteins. 


Our paper on StaPLs (stabilizable polypeptide linkages) that allow proteins to be preserved and activated by a clinically approved class of antiviral drugs, has been published in Nature Methods: . Congratulations to Conor and Ryan!


Our paper "Excitation wavelength optimization improves photostability of ASAP-family GEVIs", a collaboration with Guoqiang Bi’s lab, has been published in Molecular Cell. PDF