Cell cycle adaptation to aneuploidy:
How do cells adapt to carrying an extra chromosome?

Here, we are interested in understanding one key aspect of this relationship: how do cells respond to the challenge of packaging extra DNA? We aim to address this in yeast that are forced to carry an extra chromosome with minimal transcriptional potential, using a combination of experimental evolution (led by the Sherlock Lab at Stanford) and cell biological profiling (in the Dey Group at EMBL). What solutions do cells evolve to cope with aneuploidy, independent of problems with gene expression and dosage? What impact does an extra chromosome have on the size and organisation of the nucleus, the chromosome segregation machinery, and the cell cycle regulatory network?

This project is supported by a Bridging Excellence Fellowship, awarded to Jana Helsen. 

References:
_{Levy, S. F., Blundell, J. R., Venkataram, S., Petrov, D. A., Fisher, D. S. and Sherlock, G. (2015). Quantitative evolutionary dynamics using high-resolution lineage tracking. Nature 519, 181–186.}

_{Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J. and Amon, A. (2007). Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science (80-. ). 317, 916–924.}

_{Torres, E. M., Dephoure, N., Panneerselvam, A., Tucker, C. M., Whittaker, C. A., Gygi, S. P., Dunham, M. J. and Amon, A. (2010). Identification of aneuploidy-tolerating mutations. Cell 143, 71–83.}