The Leeper laboratory studies the vascular biology of atherosclerosis and aneurysm disease.  We are interested in the molecular mechanisms that mediate vascular disease, and developing new translational therapies directed against them.  Our group uses a combination of hypothesis-free genetic approaches, favoring the concept that insights generated in this manner are likely to have relevance to human disease.  Currently, our major focus is on the chromosome 9p21 locus, which is widely recognized as the most important heritable cardiovascular locus identified through genome-wide association studies (GWAS).   We seek to fully explain how this locus - which affects over 20% of the population - potentiates coronary disease, stroke and aneurysms, and does so independently of all classical risk factors.   Our group pursues the goal of true ‘bench-to-bedside’ translation, and includes a basic genetics, molecular biology and mouse model team, as well as a translational Vascular Medicine team which performs early-phase clinical research.  Ultimately, we seek to develop a platform of new therapies directed against atherosclerosis, which is now the leading killer worldwide. 


News, Events, & Team Milestones

Publication in Nature

Experimental anticancer drug may tackle heart disease, too.  

Robert W. Hobson, II, MD Early Career Investigator Award

Congratulations to Alyssa Flores on being awarded the Robert W. Hobson, II, MD Early Career Investigator Award. The award is issued by the American Heart Association’s Council on Peripheral Vascular disease and recognizes excellence in basic or clinical science in early career investigators in vascular and endovascular medicine, vascular surgery, or vascular biology. She will be given the award at the 2018 ATVB|PVD Scientific Sessions.


Alyssa Flores awarded renewal of HHMI Fellowship grant

Alyssa Flores awarded renewal of HHMI Fellowship grant. She will continue work studying cardiovascular genetics and nanotherapies for atherosclerosis. Congratulations to Alyssa for securing this competitive funding!

Dr. Leeper Participates in 1st Stanford Health Care Facebook Live Event

Dr. Nicholas Leeper, associate professor in the Division of Vascular Surgery, joined Stanford Cardiologists Drs. Abha Khandelwal and Marco Perez to discuss the latest trends in preventing heart disease, options for treatment and more in a Facebook Live Event on February 22, 2018. 

Watch the Video Here