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The Leeper laboratory studies the vascular biology of atherosclerosis and aneurysm disease.  We are interested in the molecular mechanisms that mediate vascular disease, and developing new translational therapies directed against them.  Our group uses a combination of hypothesis-free genetic approaches, favoring the concept that insights generated in this manner are likely to have relevance to human disease.  Currently, our major focus is on the chromosome 9p21 locus, which is widely recognized as the most important heritable cardiovascular locus identified through genome-wide association studies (GWAS).   We seek to fully explain how this locus - which affects over 20% of the population - potentiates coronary disease, stroke and aneurysms, and does so independently of all classical risk factors.   Our group pursues the goal of true ‘bench-to-bedside’ translation, and includes a basic genetics, molecular biology and mouse model team, as well as a translational Vascular Medicine team which performs early-phase clinical research.  Ultimately, we seek to develop a platform of new therapies directed against atherosclerosis, which is now the leading killer worldwide. 


News, Events, and Team Milestones

Publication in Nature Nanotechnology

Trojan horse nanoparticles deliver anti-atherosclerotic therapy specifically to the diseased blood vessel

Stanford Vascular Medicine cared for oldest competitive diver.

Dr. Nick Leeper and the Vascular Medicine team cared for the oldest competitive diver in the country who is 92!  Viki Tamaradze discusses the integrated care she received at Stanford Vascular Medicine in her pursuit of a National championship.

Watch the ABC news clip here

Vascular Medicine Fellowship - Tom Alsaigh, MD

We are excited to announce the 2020-2021 Vascular Medicine Fellow, Tom Alsaigh, MD.  Please join us in welcoming Dr. Alsaigh to the team. Tom is currently an NIH KL2 Clinical Scholar at the Scripps Research Translational Institute/TSRI in San Diego where his work has focused on translational genomics and vascular disease. He completed his Internal Medicine residency at Scripps Clinic and is pursuing fellowship in vascular medicine.

Anticoagulation Forum | Ansell Fellowship

Congratulations to Stanford Vascular Medicine for receiving the Ansell Fellowship which provides funding for educational opportunities to the next generation of clinical investigators who will further improve upon current vascular disease management and anticoagulation treatment paradigms.
Learn more about the Ansell Fellowship Program

Dr. Nanda's New Position

Congratulation to Dr. Vivek Nanda for establishing his tenure-track research laboratory at the University of Alabama, Birmingham!  Excited to see what the future holds for Vivek and his team!