The Leeper laboratory studies the vascular biology of atherosclerosis and aneurysm disease.  We are interested in the molecular mechanisms that mediate vascular disease, and developing new translational therapies directed against them.  Our group uses a combination of hypothesis-free genetic approaches, favoring the concept that insights generated in this manner are likely to have relevance to human disease.  Currently, our major focus is on the chromosome 9p21 locus, which is widely recognized as the most important heritable cardiovascular locus identified through genome-wide association studies (GWAS).   We seek to fully explain how this locus - which affects over 20% of the population - potentiates coronary disease, stroke and aneurysms, and does so independently of all classical risk factors.   Our group pursues the goal of true ‘bench-to-bedside’ translation, and includes a basic genetics, molecular biology and mouse model team, as well as a translational Vascular Medicine team which performs early-phase clinical research.  Ultimately, we seek to develop a platform of new therapies directed against atherosclerosis, which is now the leading killer worldwide. 


Vascular Surgery/CVI UTL Faculty

The Department of Surgery, Division of Vascular Surgery and the Cardiovascular Institute seek a faculty member in the University Tenure Line (UTL) at the Assistant or Associate Professor level. Clinical effort may or may not be required for the candidate, based on their professional training and career focus.

Candidates with expertise in all facets of biomedical research (discovery, translational and/or clinical science) are encouraged to apply.

This faculty billet will be split between the Division of Vascular Surgery and the Cardiovascular Institute (CVI; cvi.stanford.edu). This joint appointment has been proposed to provide the successful candidate with seamless access to the robust infrastructure of both groups and enhance the collaborations that already exist between the Division of Vascular Surgery and the Cardiovascular Institute.

Vascular Medicine Fellowship

The Division of Vascular Surgery at the Stanford School of Medicine is proud to offer the Stanford Vascular Medicine fellowship.  The Stanford Vascular Medicine fellowship is an integrated multidisciplinary program with the goal of producing Vascular Medicine specialists with expertise in the diagnosis and non-invasive treatment of a wide spectrum of arterial, venous and lymphatic diseases. This Non-ACGME accredited 1-year fellowship is for fellows who have finished at minimum a 3-year Internal Medicine residency and wishes to expand their expertise in Vascular Medicine.

The curriculum covers a wide range of approaches in vascular disease management as well as advanced training related to wound care, noninvasive imaging, and therapeutic approaches. To obtain this diverse body of expertise and knowledge, the fellow will rotate through multiple specialties including those in vascular surgery, cardiology, endocrinology, hematology, rheumatology, neurology and radiology.

Vascular Medicine is a fertile area for scientific investigation and this program will provide experience to suitably equipped individuals who seek to assume a leadership role in academic Vascular Medicine.

News, Events, & Team Milestones

Publication in Nature

Experimental anticancer drug may tackle heart disease, too.  

Young Talent Award

Congratulations to outstanding post-doc Ying Wang for receiving a ‘Young Talent’ award from the Fondation Leducq to study the role of somatic mutations and epigenetic modifications in vascular smooth muscle cells during atherogenesis.

White Coat Ceremony

Congrats to former Leeper lab member and Firestone Award winner, Sophia Xiao, on her white coat ceremony and starting medical school at UCSD!

Vascular Medicine Graduation

Congratulations to Dr. Rana! Link to Dr. Fukaya's full graduation remarks

Dr. Mohammad Atif Rana's Vascular Medicine Graduation

Notice of K01 Award

Huge congratulations to Leeper lab alumna, incredible surgeon-scientist, and even better human being on her K-grant notice of award.  Way to go Elsie!

Promotion to Professor

Congratulations to Dr. Leeper on his promotion to Professor! The University Provost approved the promotion of Dr. Nicholas Leeper to Professor in the Department of Surgery and the Department of Medicine, effective August 1, 2019. Join us in congratulating Dr. Leeper on this well-deserved promotion!