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Affiliated Sites

 

Levy, Ronald, MD
(650) 725-6452

Appointments

Chief, Department of Oncology

Professor of Oncology

Weissman, Irving L
Honors & Awards
Jeffrey A. Gottlieb Memorial Award, M.D. Anderson Cancer Center, 2003
Evelyn Hoffman Memorial Award, Lymphoma Research Foundation of America , 2001
Key to the Cure Award, Cure for Lymphoma Foundation, 2001
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Professional Education
A.B., Harvard University, 1963
M.D., Stanford University, 1968
Web Links
Lab site: http://med.stanford.edu/labs/ronald_levy/

Research Intererests

Our research concentrates on the study of malignant lymphoma and tumors of the immune system using the tools of immunology and molecular biology to develop a better understanding of the initiation and progression of the malignant process. Receptor molecules present on the surface of tumor cells transmit signals for regulation of cell growth. These receptors include the immunoglobulin molecule on B cell tumors and the T cell receptor on T cell tumors. Questions the lab is currently addressing include:

  1. Can a clue to the pathogenesis of lymphoma be derived from a study of their antigen receptors?
  2. Can new treatments for lymphoma be developed by targeting receptors with monoclonal antibodies?
  3. Can vaccines be developed which can induce an immune response in the host against the receptors on their own tumor?

Representative Publications

Vuist W, Maloney D, Levy R. (1994). Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce immunoglobulins signal transduction and is not prevented by tumor expression of high levels of Bcl-2 protein. Blood 83(4):899–906.

Maloney D, Liles T, Czerwinski D, Waldichuk C, Rosenberg J, Grillo-Lopez A, Levy R. (1994). Phase I clinical trial using escalating single dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Blood 84(8):2457–2466.

Hsu F, Benike C, Fagnoni F, Liles TM, Czerwinski D, Taidi B, Engleman EG, Levy R. (1996). Vaccination of patients with B cell lymphoma using autologous antigen pulsed dendritic cells. Nature Medicine 2:52–58.

Syrengelas A, Chen T, Levy R. (1996). DNA immunization induces protective immunity against B cell lymphoma. Nature Medicine 2: 1038–41.

Hsu F, Caspar C, Czerwinski D, Kwak L, Liles T, Syrengelas A, Taidi-Laskowski B, Levy R. (1997). Tumor-specific idiotype vaccines in the treatment of patients with B cell lymphoma; long-term results of a clinical trial. Blood 89:3129-3135.

    Complete list of publications

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