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Representative Publications

  Please click the link below for a complete list of publications on the Academic Profile of Dr. Marlene Rabinovitch.

Marlene Rabinovitch, MD - Publications


Please click the link below for a complete list of publications on the Academic Profile of Dr. Richard Bland.

Richard D Bland, MD - Publications

 

Selected Publications - Dr. Rabinovitch:

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and its Target Slug.
Hopper RK, Moonen J-R AJ, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M.   Circulation; published ahead of print on April 4 2016 as doi:10.1161/CIRCULATIONAHA.115.020617

Accompanying Editorial: Endothelial-to-Mesenchymal Transition: An Evolving Paradigm and a Promising Therapeutic Target in PAH. Stenmark KR, Frid M, Perros F.   Circulation; Published ahead of print on April 4 2016 as doi:10.1161/CIRCULATIONAHA.116.022479

RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension
Rhodes, C. J., Im, H., Cao, A., Hennigs, J. K., Wang, L., Sa, S., Chen, P., Nickel, N. P., Miyagawa, K., Hopper, R. K., Tojais, N. F., Li, C. G., Gu, M., Spiekerkoetter, E., Xian, Z., Chen, R., Zhao, M., Kaschwich, M., del Rosario, P. A., Bernstein, D., Zamanian, R. T., Wu, J. C., Snyder, M. P., Rabinovitch, M. Am J Respir Crit Care Med.  2015; 192 (3): 356-366

Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
Nickel, N. P., Spiekerkoetter, E., Gu, M., Li, C. G., Li, H., Kaschwich, M., Diebold, I., Hennigs, J. K., Kim, K., Miyagawa, K., Wang, L., Cao, A., Sa, S., Jiang, X., Stockstill, R. W., Nicolls, M. R., Zamanian, R. T., Bland, R. D., Rabinovitch, M. Am J Respir Crit Care Med. 2015; 191 (11): 1273-1286

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
Diebold, I., Hennigs, J. K., Miyagawa, K., Li, C. G., Nickel, N. P., Kaschwich, M., Cao, A., Wang, L., Reddy, S., Chen, P., Nakahira, K., Alcazar, M. A., Hopper, R. K., Ji, L., Feldman, B. J., Rabinovitch, M.
Cell Metabolism2015; 21 (4): 596-608

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
Rabinovitch, M., Guignabert, C., Humbert, M., Nicolls, M.
R. Circ Res.  2014; 115 (1): 165-175

Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
Sawada, H., Saito, T., Nickel, N. P., Alastalo, T., Glotzbach, J. P., Chan, R., Haghighat, L., Fuchs, G., Januszyk, M., Cao, A., Lai, Y., Perez, V. D., Kim, Y., Wang, L., Chen, P., Spiekerkoetter, E., Mitani, Y., Gurtner, G. C., Sarnow, P., Rabinovitch, M. J Exp Med. 2014; 211 (2): 263-280

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter, E., Tian, X., Cai, J., Hopper, R. K., Sudheendra, D., Li, C. G., El-Bizri, N., Sawada, H., Haghighat, R., Chan, R., Haghighat, L., de Jesus Perez, V., Wang, L., Reddy, S., Zhao, M., Bernstein, D., Solow-Cordero, D. E., Beachy, P. A., Wandless, T. J., ten Dijke, P., Rabinovitch, M.   J Clin Invest. 2013; 123 (8): 3600-3613

Combining induced pluripotent stem cell with next generation sequencing technology to gain new insights into pathobiology and treatment of pulmonary arterial hypertension. Rabinovitch, M. Pulmonary Criculation. 2013; 3 (1): 153-155

Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans.
de Jesus Perez, V. A., Yuan, K., Orcholski, M. E., Sawada, H., Zhao, M., Li, C. G., Tojais, N. F., Nickel, N., Rajagopalan, V., Spiekerkoetter, E., Wang, L., Dutta, R., Bernstein, D., Rabinovitch, M.
Circ Res. 2012; 111 (12): 1551-1564

Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions
Kim, Y., Haghighat, L., Spiekerkoetter, E., Sawada, H., Alvira, C. M., Wang, L., Acharya, S., Rodriguez-Colon, G., Orton, A., Zhao, M., Rabinovitch, M. Am J Pathol. 2011; 179 (3): 1560-1572

Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
Alastalo, T., Li, M., Perez, V. D., Pham, D., Sawada, H., Wang, J. K., Koskenvuo, M., Wang, L., Freeman, B. A., Chang, H. Y., Rabinovitch, M.
  J Clin Invest.  2011; 121 (9): 3735-3746

Inhibition of Transforming Growth Factor beta Worsens Elastin Degradation in a Murine Model of Kawasaki Disease Alvira, C. M., Guignabert, C., Kim, Y., Chen, C., Wang, L., Duong, T. T., Yeung, R. S., Li, D. Y., Rabinovitch, M. Am J Pathol.  2011; 178 (3): 1210-1220

BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
Perez, V. A., Ali, Z., Alastalo, T., Ikeno, F., Sawada, H., Lai, Y., Kleisli, T., Spiekerkoetter, E., Qu, X., Rubinos, L. H., Ashley, E., Amieva, M., Dedhar, S., Rabinovitch, M.
J Cell Biol.  2011; 192 (1): 171-188

This article is featured in biobytes podcast, http://jcb.rupress.org/content/192/1/171/suppl/DC2

Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization Guignabert, C., Alvira, C. M., Alastalo, T., Sawada, H., Hansmann, G., Zhao, M., Wang, L., El-Bizri, N., Rabinovitch, M..  Am J Physiol Lung Cell Mol Physiol. 2009; 297 (6): L1082-L1090

S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho-Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
Spiekerkoetter, E., Guignabert, C., Perez, V. D., Alastalo, T., Powers, J. M., Wang, L., Lawrie, A., Ambartsumian, N., Schmidt, A., Berryman, M., Ashley, R. H., Rabinovitch, M.
Circ Res. 2009; 105 (7): 639-U37

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
Perez, V. A., Alastalo, T., Wu, J. C., Axelrod, J. D., Cooke, J. P., Amieva, M., Rabinovitch, M. J Cell Biol.  2009; 184 (1): 83-99

SM22 alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
El-Bizri, N., Guignabert, C., Wang, L., Cheng, A., Stankunas, K., Chang, C., Mishina, Y., Rabinovitch, M. Development . 2008; 135 (17): 2981-2991

Marlene Rabinovitch, MD - All Publications


Selected Publications, Richard D Bland, MD:

Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice
Hilgendorff, A., Parai, K., Ertsey, R., Navarro, E., Jain, N., Carandang, F., Peterson, J., Mokres, L., Milla, C., Preuss, S., Alcazar, M. A., Khan, S., Masumi, J., Ferreira-Tojais, N., Mujahid, S., Starcher, B., Rabinovitch, M., Bland, R.  Am J Physiol Lung Cell Mol Physiol. 2015; 308 (5): L464-L478 .

Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
Nickel, N. P., Spiekerkoetter, E., Gu, M., Li, C. G., Li, H., Kaschwich, M., Diebold, I., Hennigs, J. K., Kim, K., Miyagawa, K., Wang, L., Cao, A., Sa, S., Jiang, X., Stockstill, R. W., Nicolls, M. R., Zamanian, R. T., Bland, R. D., Rabinovitch, M. Am J Respir Crit Care Med. 2015; 191 (11): 1273-1286

Neonatal Mice Genetically Modified to Express the Elastase Inhibitor Elafin are Protected Against the Adverse Effects of Mechanical Ventilation on Lung Growth
Hilgendorff A, Parai K, Ertsey R, Juliana Rey-Parra G, Thébaud B, Tamosiuniene R, Jain N, Navarro EF, Starcher BC, Nicolls MR, Rabinovitch M, Bland RD.   Am J Physiol Lung Cell Mol Physiol. 2012 Aug;303(3):L215-27.

Inhibiting Lung Elastase Activity Enables Lung Growth in Mechanically Ventilated Newborn Mice
Hilgendorff A, Parai K, Ertsey R, Jain N, Navarro EF, Peterson JL, Tamosiuniene R, Nicolls MR, Starcher BC, Rabinovitch M, Bland RD. Am J Respir Crit Care Med. 2011; Sep 1;184(5):537-46.
Editorial: Targeting Elastase in Bronchopulmonary Dysplasia Morty RE, Am J Respir Crit Care Med. 2011; 184. pp. 496-497 (2011)

Prolonged Mechanical Ventilation with Air Induces Apoptosis and Causes Failure of Alveolar Septation and Angiogenesis in Lungs of Newborn Mice.
Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD. Am J Physiol Lung Cell Mol Physiol 2010; 298: L23-35. 

Mechanical Ventilation Uncouples Synthesis and Assembly of Elastin and Increases Apoptosis in Lungs of Newborn Mice
Bland, RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A.
Am J Physiol Lung Cell Mol Physiol. 2008; 294: L3-L14.

Mechanical Ventilation with 40% Oxygen Reduces Pulmonary Expression of Genes that Regulate Lung Development and Impairs Alveolar Septation in Newborn Mice
Bland RD, Mokres LM, Ertsey R, Jacobson BE, Jiang S, Rabinovitch M, Xu L, Shinwell ES, Zhang F, Beasley MA.
Am J Physiol Lung Cell Mol Physiol. 2007; 293: L1099-L1110.

Dysregulation of Pulmonary Elastin Synthesis and Assembly in Preterm Lambs with Chronic Lung Disease
Bland RD, Xu L, Ertsey R, Rabinovitch M, Albertine KH, Kumar VH. Ryan RM, Swartz DD, Wynn KA. Csiszar K, Fong KSK.
Am J Physiol Lung Cell Mol Physiol 292: L1370-L1384.

Inhaled Nitric Oxide Effects on lung Structure and Function in Chronically Ventilated Preterm Lambs
Bland, RD, Albertine, KH, Carlton, DP and MacRitchie, AJ.
Am. J. Respir. Crit. Care Med. 2005; 172: 899-906.

Richard D Bland, MD - All Publications

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Richard D Bland, MD - selected Publications

Marlene Rabinovitch, MD - selected Publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Marlene Rabinovitch, MD - selected Publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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