Scott Lab In The Department of Developmental Biology

Scott Lab Publications: 1990-1999

39. Ueda, H., S. Sonoda, J.L. Brown, M.P. Scott, and C. Wu (1990) A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression. Genes and Development 4: 624-635.

40. Reuter, R. and M.P. Scott (1990) Expression and functions of the homeotic genes Antennapedia and Sex combs reduced in the embryonic midgut of Drosophila. Development 109: 289-303.

41. Bermingham, J.R., A. Martinez-Arias, M. G. Petitt, and M.P. Scott (1990) Different patterns of transcription from the two Antennapedia promoters during Drosophila embryogenesis. Development 109: 553-566.

42. Reuter, R., G.E.F. Panganiban, F.M. Hoffmann , and M.P. Scott (1990) Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos. Development 110:,1031-1040. [PDF Reprint]

43. Panganiban, G.E.F., R. Reuter, M.P. Scott, and F.M. Hoffmann (1990) A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis. Development 110:,1041-1050. [PDF Reprint]

44. Hayashi, S. and M.P. Scott (1990) What determines the specificity of action of Drosophila homeodomain proteins? Cell 63: 883-894. [PDF Reprint]

45. Tamkun, J.W., R.A. Kahn, M. Kissinger, B.J. Brizuela, C. Rulka, M.P. Scott, and J.A. Kennison (1991) The arflike gene encodes an essential GTP-binding protein in Drosophila. Proc. Nat. Acad. Sci. U.S.A.88: 3120-3124. [PDF Reprint]

46. Brown, J.L., S. Sonoda, H. Ueda, M.P. Scott, and C. Wu (1991) Repression of fushi tarazu (ftz) segmentation gene. EMBO J.10: 665-674. [PDF Reprint]

47. Doe, C.Q., Q. Chu-LaGraff, D.M. Wright, and M.P. Scott (1991) The prospero gene specifies cell fates in the Drosophila central nervous system. Cell 65: 451-464. [PDF Reprint]

48. Tamkun, J.W., R. Deuring, M.P. Scott, M. Kissinger, A.M. Pattatucci, T.C. Kaufman, and J.A. Kennison (1992) brahma: A transregulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell 68: 561-572. [PDF Reprint]

49. Andrew, D.J. and M.P. Scott (1992) Downstream of the homeotic genes. New Biologist 4: 5-15. [PDF reprint]

50. Oh, S.-K., M.P. Scott, and P. Sarnow (1992) Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding. Genes and Development 6: 1643-1653. [PDF Reprint]

51. Hooper, J.E., M. Pérez-Alonso, J.R. Bermingham, M. Prout, B.A. Rocklein, M. Wagenbach, J.-E. Edstrom, R. De Frutos, and M.P. Scott (1992) Comparative studies of Drosophila Antennapedia genes. Genetics 132: 453-469. [PDF Reprint]

52. Petitt, M.G. and M.P. Scott (1992) Gene control systems affecting insect development. (Eds. J.M. Crampton and P. Eggleston). in Insect Molecular Science, 16th Symp. Roy. Entomol. Soc., Academic Press, London.

53. Hooper, J.E. and M.P. Scott (1992) The molecular genetic basis of positional information in insect segments. In: Early Embryonic Development of Animals, volume 18 of "Results and Problems in Cell Differentiation", pp.1-48. W. Hennig, Ed. Springer-Verlag, Berlin.

54. Crabtree, G.R., U. Schibler, and M.P. Scott (1992) Transcriptional regulatory mechanisms in liver and midgut morphogenesis of vertebrates and invertebrates. In: Transcriptional Regulation (S.L. McKnight and K. R. Yamamoto, Eds.) Cold Spring Harbor Press, Cold Spring Harbor, N.Y., pp1063-1102

55. Manak, J.R. and M.P. Scott (1993) Able assistants for homeodomain proteins. Current Biology 3:318-320. [PDF Reprint]

56. Scott, M.P. (1993) A rational nomenclature for vertebrate homeobox (HOX) genes. Nucleic Acids Research 21: 1687-1688. [PDF Reprint]

57. Zeng, W., D.J. Andrew, L.D. Mathies, M.A. Horner, and M.P. Scott (1993) Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomain is critical to functional specificity. Development 118: 339-352. [PDF Reprint]

58. Andrew, D.J., M.A. Horner, M.G. Petitt, Sarah M. Smolik, and M.P. Scott (1994) Setting limits on homeotic gene function: Restraint of Sex combs reduced Activity by teashirt and other homeotic genes. EMBO J.13: 1132-1144. [PDF Reprint]

59. Peterson, C.L., A. Dingwall, and M.P. Scott (1994) Five SWI/SNF gene products are components of a large multi-subunit complex required for transcriptional enhancement. Proc. Nat. Acad. Sci. U.S.A.91: 2905-2908. [PDF Reprint]

60. Schuske, K., J.E. Hooper, and M.P. Scott (1994) patched overexpression causes loss of wingless expression in Drosophila embryos. Dev. Biol.. 164: 300-311. [PDF Reprint]

61. Mathies, L.D., S. Kerridge, and M.P. Scott (1994) Role of the teashirt gene in Drosophila midgut morphogenesis: Secreted proteins mediate the action of homeotic genes. Development 120: 2799-2809. [PDF Reprint]

62. Andrew, D.J. and M.P. Scott (1994) Immunological methods to map protein distributions on polytene chromosomes. In Drosophila melanogaster: Practical Uses in Cell and Molecular Biology. L.S.B. Goldstein and E. Fyrberg, Eds., pp. 353-370, Academic Press.

63. Manak, J.R., L.D. Mathies, and M.P. Scott (1994) Regulation of a decapentaplegic enhancer by homeotic proteins. Development 120: 3605-3619. [PDF Reprint]

64. Scott, M.P. (1994) Intimations of a creature. Cell 79: 1121-1124. [PDF Reprint]

65. Manak, J.R. and M.P. Scott (1994) A class act: Conservation of homeodomain protein functions. In: The Evolution of Development Mechanisms. Development Suppl. 1994, pp. 61-77.

66. Dingwall, A.K., S.J. Beek, C.M. McCallum, J.W. Tamkun, G.V. Kalpana, S.P. Goff, and M.P. Scott (1995) The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. Mol. Biol. Cell. 6: 777-791. [PDF Reprint]

67. McCormick, A., N. Coré, S. Kerridge, and M.P. Scott (1995) Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene. Development 121: 2799-2812. [PDF Reprint]

68. Saenz-Robles, M.T., F. Maschat, T. Tabata, M.P. Scott, and T.B. Kornberg (1995) Selection and characterization of sequences with high affinity for the engrailed protein of Drosophila. Mech. Devel. 53: 185-195. [PDF Reprint]

69. Bilder, D. and M.P. Scott (1995) Genomic regions required for morphogenesis of the Drosophila embryonic midgut. Genetics 141: 1087-1100. [PDF Reprint]

70. Johnson, R.L., J. K. Grenier, and M.P. Scott (1995) patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets. Development 121: 4161-4170. [PDF Reprint]

71. Goodrich, L.V., R.L. Johnson, L. Milenkovic, J.A. McMahon, and M.P. Scott (1996) Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by hedgehog. Genes Dev. 10: 301-312. [PDF Reprint]

72. Marigo, V., M.P. Scott, E. Laufer, L.V. Goodrich, R.L. Johnson, and C. Tabin (1996) Conservation in hedgehog signaling: Sonic hedgehog controls the expression of a chicken patched homolog in the developing limb. Development 122: 1225-1233. [PDF Reprint]

73. Johnson, R.L., A.L. Rothman, J. Xie, L.V. Goodrich, J.W. Bare, J.M. Bonifas, A.G. Quinn, R.M. Myers, D.R. Cox, E.H. Epstein, Jr., and M.P. Scott (1996) Human homolog of patched , a candidate gene for the basal cell nevus syndrome. Science 272: 1668-1671. [PDF Reprint]

74. Concordet, J-P., K.E. Lewis, J.W. Moore, L. V. Goodrich, R. L. Johnson, M. P. Scott and P. W. Ingham (1996) Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122: 2835-2846. [PDF Reprint]

75. Epstein, D.J., E. Marti, M.P. Scott, and A.P. McMahon (1996) Antagonizing cAMP-dependent protein kinase A in tbe dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122: 2885-2894. [PDF Reprint]

76. Stone, D.M., M. Hynes, M. Armanini, T.A. Swanson, Q. Gu, R.L. Johnson, M.P. Scott, D. Pennica, A. Goddard, H. Phillips, M. Noll, J.E. Hooper, F. de Sauvage, and A. Rosenthal (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134. [PDF Reprint]

77. Scott, M.P. (1997) Hox genes, Arms and the Man. Nature Genetics 15: 117-118. [PDF Reprint]

78. Sharkey, M., Y. Graba, and M.P. Scott (1997) Hox genes in evolution: Protein surfaces and paralog groups. Trends in Genetics 13: 145-151. [PDF reprint]

79. Oro, A.E., K.M. Higgins, Z. Hu, J.M. Bonifas, E. H. Epstein, Jr., and M.P. Scott (1997) Basal cell carcinomas in mice overexpressing Sonic Hedgehog. Science 276: 817-821. [PDF reprint]

80. Kornberg, T. and M.P. Scott (1997) Regulation of Drosophila development by transcription factors and cell-cell signaling in Exploring Genetic Mechanisms. P. Berg and M. Singer, Eds. University Science Books, Sausalito, California.

81. Xie, J., R.L. Johnson, X. Zhang, J.W. Bare, F.M. Waldman, P.H. Cogen, A.G. Menon, M.P. Scott, and E.H. Epstein, Jr. (1997) The PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Research 57: 2369-2372. [PDF Reprint]

82. Fan, H., A.E. Oro, M.P. Scott, and P.A. Khavari (1997) Induction of basal cell carcinoma features in transgenic human skin expressing Sonic hedgehog. Nature Medicine 3: 788-792. [PDF Reprint]

83. Sisson, J.C., K.S. Ho, K. Suyama, and M.P. Scott (1997) Costal2, a novel kinesin-related protein in the Hedgehog/patched signaling pathway. Cell 90: 235-245. [PDF reprint]

84. Goodrich, L.V., L. Milenkovic, K.M. Higgins, and M. P. Scott (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277: 1109-1113. [PDF reprint]

85. Johnson, R.L. and M.P. Scott (1997) Control of cell growth and fate by patched genes. Cold Spring Harbor Symp. Quant. Biol. 62: 205-215. [PDF Reprint]

86. Scott, M.P. (1997) A common language (meeting summary). Cold Spring Harbor Symp. Quant. Biol. 62: 555-562. [PDF Reprint]

87. Coré, N., A. McCormick, C. Vola, L. Fasano, M.P. Scott, and S. Kerridge (1997) Initiation of embryonic transcription of the Drosophila homeotic gene teashirt requires fushi tarazu gene activity. Mech. Devel. 68:157-72. [PDF reprint]

88. Bilder, D., Y. Graba, and M.P. Scott (1997) Wnt and TGF? signals subdivide the AbdA Hox domain during mesoderm patterning. Development 125: 1781-1790. [PDF reprint]

89. Aszterbaum, M., A. Rothman, R.L. Johnson, M. Fisher, J. Xie, J.M. Bonifas, X. Zhang, M.P. Scott, and E.H. Epstein, Jr. (1997) Mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with basal cell nevus syndrome. J. Investigative Dermatol. 110: 885-888. [PDF reprint]

90. Johnson, R.L. and M.P. Scott (1998) Hedgehog signaling: New players and perplexities join the pathway. Curr. Opin. Genet. Devel. 8: 450-456. [PDF reprint]

91. Bilder, D. and M.P. Scott (1998) Hedgehog and Wingless induce metameric pattern in the Drosophila visceral mesoderm. Devel. Biol. 201: 43-56. [PDF reprint]

92. Pennacchio, L.A., D.M. Bouley, K.M. Higgins, M.P. Scott, J.L. Noebels, and R.M. Myers (1998) Progressive ataxia, myoclonic epilepsy, and cerebellar apoptosis in cystatin B-deficient mice. Nature Genetics 20: 251-258. [PDF reprint]

93. Oro, A.E. and M.P. Scott (1998) Splitting hairs: Dissecting roles of signaling systems in epidermal development. Cell 95: 575-578. [PDF reprint]

94. Weiss, J.B., T. von Ohlen, D. Mellerick, G. Dressler, C.Q. Doe, and M.P. Scott (1998) Dorsal-ventral patterning in the Drosophila central nervous system: The intermediate neuroblast defective homeobox gene specifies intermediate column identity. Genes Dev. 12: 3591-3602. [PDF reprint]

95. Goodrich, L.V. and M.P. Scott (1998) Hedgehog and Patched in neural development and disease. Neuron 21: 1243-1257. [PDF reprint]

96. Scott, M.P. (1998) Hedgehog/patched signaling in animal development and disease in Accomplishments in Cancer Research 1997, pp. 120-124. Eds. S.A. Wells and P.A. Sharp. Lippincott, Williams & Williams.

97. Wechsler-Reya, R.J.and M.P. Scott (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog. Neuron 22: 103-114. [PDF reprint]

98. Keys, D.N., D.L. Lewis, J.E. Selegue, B.J. Pearson, L.V. Goodrich, R.L. Johnson, J. Gates, M.P. Scott, and S.B. Carroll (1999) Evolution of novelty: recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution. Science 283: 532-534. [PDF reprint]

99. Daubresse, G., R. Deuring, L. Moore, O. Papoulas, I. Zakrajsek, W.R. Waldrip, M.P. Scott, J.A. Kennison, and J.W. Tamkun (1999) The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. Development 126: 1175-1187. [PDF reprint]

100. Scott, M.P. (1999) Hox proteins reach out round DNA. Nature 397: 649. [PDF reprint]

101. Goodrich, L.V., D. Jung, K.M. Higgins, and M.P. Scott (1999) Overexpression of ptc inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Devel. Biol. 211: 323-334. [PDF reprint]

102. R.V. Pearse II, L.S. Collier, M.P. Scott, and C.J. Tabin (1999) Vertebrate homologues of Drosophila Suppressor of fused interact with the Gli family of transcriptional regulators. Devel. Biol. 212: 323-336. [PDF reprint]

103. Bailey, E. C., M. P. Scott, and R. L. Johnson (2000) Hedgehog signaling in animal development and human disease. In: Of Fish, Fly, Worm and Man: Lessons from Developmental Biology for Human Gene Function and Disease (eds. C. Nusslein-Volhard and J. Kratzschmar) Berlin, Springer Verlag, 211-235.

104. Li, Z., C.A. Karlevitch, M.P. Fish, M.P. Scott, and R.M. Myers (1999) A putative Drosophila homolog of the Huntington disease gene. Hum. Mol. Genet. 8: 1807-1815. [PDF reprint]

105. Milenkovic, L., L.V. Goodrich, K.M. Higgins, and M.P. Scott (1999) Mouse patched1 controls body size determination and limb patterning. Development 126: 4431-4440. [PDF reprint]

106. Lewis, M.T. S. Ross, P.A. Strickland, C.W. Sugnet, M.P. Scott, and C.W. Daniel (1999) Defects in mouse mammary gland development caused by conditional haploinsufficiency of patched-1 (ptc1). Development 126: 5181-5193. [PDF reprint]

107. Aszterbaum, M., J. Epstein, A.E. Oro, V. Douglas, P.E. LeBoit, M.P. Scott, and E.H. Epstein Jr. (1999) Ultraviolet and ionizing radiation enhance growth of BCCs and trichoblastomas in patched heterozygote knock?out mice. Nature Medicine 5: 1285-1291. [PDF reprint]

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