Scott Lab In The Department of Developmental Biology

Scott Lab Publications: 2000-2009

108. Scott, M.P. (2000) Development: The natural history of genes. Cell 100: 27-40. [PDF reprint]

109. Zeng, W., K.A. Wharton, Jr., J. Mack, K. Wang, M. Gadbaw, P.S. Klein, and M.P. Scott (2000) The Drosophila naked cuticle gene encodes a novel inducible feedback antagonist of Wingless/Wnt activity. Nature 403: 789-795. [PDF reprint]

110. R.H. Zurawel, C. Allen, R. Wechsler-Reya, M.P. Scott, and C. Raffel (2000) Evidence that haploinsufficiency of ptch leads to medulloblastoma in mice. Genes, Chromosomes, & Cancer 28: 77-81. [PDF reprint]

111. Chauvet, S., S. Merabet, D. Bilder, M.P. Scott, J. Pradel, and Y. Graba (2000) Distinct Hox protein sequences determine specificity in different tissues. Proc. Nat. Acad. Sci. U.S.A. 97: 4064-4069. [PDF reprint]

112. Taipale, J., M. Cooper, J. Chen, B. Wang, K. Young, R. Mann, L. Milenkovic, M.P. Scott, and P.A. Beachy (2000) Cyclopamine inhibition of Smoothened activity in the Hedgehog signaling pathway. Nature 406: 1005-1009. [PDF reprint]

113. Johnson, R.L., L. Milenkovic, and M.P. Scott (2000) In vivo function of the Patched protein: Requirement of the C-terminus for target gene inactivation but not Hedgehog sequestration. Molecular Cell 6: 467-478. [PDF reprint]

114. Furlong, E.M., D. Proffitt, and M.P. Scott (2001) Automated sorting of live transgenic embryos. Nature Biotechnology 19: 153-156. [PDF reprint]

115. Wechsler-Reya, R.J.and M.P. Scott (2001) The Developmental Biology of Brain Tumors. Ann. Rev. Neurosci. 24: 385-428. [PDF reprint]

116. Ko, D.C., M.D. Gordon, J.S. Jin, and M.P. Scott (2001) Dynamics of the NPC1 protein in the organelles of living cells. Molec. Biol. Cell 12: 601-614. [PDF reprint]

117. Rousset, R., J.A. Mack, K.A. Wharton, Jr., J.D. Axelrod, K.M. Cadigan, M.P. Fish, R. Nusse, and M.P. Scott (2001) Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Devel. 15: 658-671. [PDF reprint]

118. Papoulas, O., G. Daubresse, J. A. Armstrong, J. Jin, M. P. Scott, and J. W. Tamkun (2001) The HMG-domain protein BAP111 is important for the function of the BRM chromatin remodeling complex in vivo. Proc. Nat. Acad. U.S.A. 98: 5728-5733. [PDF reprint]

119. Wharton, Jr., K.A., G. Zimmermann, R. Rousset, and M. P. Scott (2001) Vertebrate relatives of the Drosophila Naked cuticle protein bind Dishevelled and antagonize Wnt signaling. Dev. Biol. 234: 93-106. [PDF reprint]

120. Scott, M.P. (2001) Signalling and endocytosis: Wnt breaks down on back roads. Nature Cell Biol. 3: E185-186. [PDF reprint]

121. Furlong, E.E.M., E.C. Anderson, B. Null, K.P. White, and M. P. Scott (2001) Patterns of gene transcription during Drosophila mesoderm development. Science 293: 1629-1633. [PDF reprint]

122. Weiss, J.B., K. L. Suyama, and M. P. Scott (2001) Jelly belly: A novel LDL receptor repeat-containing signal required for mesoderm migration and differentiation. Cell 107: 387-398. [PDF reprint]

123. Corcoran, R. and M.P. Scott (2001) A mouse model for medulloblastoma and basal cell nevus syndrome. J. Neurooncology 53: 307-318. [PDF reprint]

124. Ho, K.S. (2002) Sonic hedgehog in the nervous system: Functions, modifications, and mechanisms. Curr. Opin. Neurobiol. 12: 57-63. [PDF reprint]

125. Tree, D.R.P., J.M. Shulman, R. Rousset, M.P. Scott, and J.D. Axelrod (2002) Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109: 371-381. [PDF reprint]

126. Monnier, V., K.S. Ho, M. Sanyal, M.P. Scott, and A. Plessis (2002) Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev. Biol. 2:4. [PDF reprint]

127. Bailey, E.C., L. Milenkovic, M.P. Scott and R.L. Johnson (2002) Several PATCHED1 missense mutations display activity in patched1 deficient fibroblasts. J. Biol. Chem. 277: 33632-33640. [PDF reprint]

128. Arbeitman, M.N., E.E.M. Furlong, F. Imam, E. Johnson, B.H. Null, B.S. Baker, M.A. Krasnow, M.P. Scott, R.W. Davis, and K. P. White (2002) A genomic analysis of gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275. [PDF reprint]

129. Armstrong, J.A., O. Papoulas, G. Daubresse, A.S. Sperling, J.T. Lis, M.P. Scott, and J.W. Tamkun (2002) The Drosophila BRM complex facilitates global transcription by RNA polymerase. EMBO J. 21: 5245-5254. [PDF reprint]

130. Rousset, R., K.A. Wharton, Jr., G. Zimmermann, and M.P. Scott (2002) Zinc-dependent interaction between Dishevelled and the Wingless/Wnt antagonist Naked Cuticle. J. Biol. Chem. 277: 49019-49026. [PDF reprint]

131. Ko, D.C., J. Binkley, A. Sidow, and M. P. Scott (2003) The integrity of a cholesterol-binding pocket in NPC2 is necessary for maintenance of lysosomal cholesterol levels. Proc. Nat. Acad. U.S.A. 100: 2518-2525. [PDF reprint]

132. Zhu A. J., L. Zheng, K. Suyama, K. S. Ho, R. L. Johnson, and M. P. Scott (2003) Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17: 1240-1252. [PDF reprint]

133. Motoyama, J. L. Milenkovic, M. Iwama, Y. Shikata, M.P. Scott, and C.-c. Hui (2003) Differential requirement for Gli2 and Gli3 in ventral neural specification. Dev. Biol. 259: 150-161. [PDF reprint]

134. Oliver, T.G., L.L. Grasfeder, A.L. Carroll, C. Kaiser, C.L. Gillingham, S.M. Lin, R. Wickramisinghe, M.P. Scott, and R.J. Wechsler-Reya (2003) Transcriptional profiling of the Sonic Hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc. Nat. Acad. Sci. U.S.A. 100: 7331-7336. [PDF reprint]

136. Grienenberger, A., S. Merabet, I. Iltis, J. Manak, H. Berenger, M.P. Scott, J. Pradel, and Y. Graba (2003) TGFb signaling modulates Hox protein regulation of a wingless enhancer. Development 130: 5445-5455. [PDF reprint]

137. Scott, M.P. (2003) A twist in the Hedgehog's tale. Nature 425: 780-782. [PDF reprint]

138. Artero, R., E.E.M. Furlong, K. Beckett, M.P. Scott, and M. Baylies (2003) Notch and Ras signaling pathway effector genes expressed in fusion-competent and founder cells during Drosophila myogenesis. Development 130: 6257-6272. [PDF reprint]

139. Chen, C.C., S. Zappe, O. Sahin, X.J. Zhang, M. Fish, M.P. Scott, and O. Solgaard (2004) Design and operation of a microfluidic sorter for Drosophila embryos.  Sensors and Actuators B. Chemical. 102: 59-66. [PDF Reprint]

140. Bernstein, R.W., X. Zhang, S. Zappe, M. Fish, M.P. Scott, and O. Solgaard (2004) Characterization of fluidic microassembly for immobilization and positioning of Drosophila embryos in 2-D arrays   Sensors and Actuators A: Physical. 114: 191-196. [PDF reprint]

141.  Zhang, X.J., S. Zappe, R. W. Bernstein, O. Sahin, C. -C. Chen, M. Fish, M. P. Scott, and O. Solgaard (2004) Micromachined silicon force sensor based on diffractive optical encoders for characterization of microinjection.  Sensors and Actuators A: Physical. 114: 197-203. [PDF reprint].

142. Wang, Q.T., K. Piotrowska, L. Milenkovic, M.P. Scott, R.W. Davis, and M. Zernicka-Goetz (2004) A genome-wide study of gene activity reveals regulated expression of polarity genes in mammalian oocytes and early embryos. Devel. Cell 6: 133-144. [PDF reprint]

143.  Collier, L.S., K. Suyama, J.H. Anderson, and M.P. Scott (2004) Drosophila Costal1 mutations influence Hedgehog signaling by modulating Protein kinase A activity. Genetics, 167:783-796. [PDF reprint]

144. Ohgami, N., S. Sugii, D.C. Ko, M.P. Scott, C.C.Y. Chang, and T.-Y. Chang. (2004) Niemann-Pick type C1 protein interacts directly with a photo-activatable cholesterol analog and the interaction requires a functional sterol-sensing domain. Proc. Nat. Acad. Sci. U.S.A. -101: 12473-12478. [PDF Reprint]

145. Zhu, A.J. and M.P. Scott (2004) Incredible journey:  How do developmental signals travel through tissue?  Genes Devel.  18(24):2985-97. [PDF reprint]

146. Ho KS, Suyama K, Fish M, Scott MP (2005). Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development. 2005 Mar;132(6):1401-12. [PDF reprint]

147. Hooper, J.E. and M.P. Scott (2005) Communicating with Hedgehogs.  Nature Rev Mol Cell Biology 6: 306-217. [PDF reprint]

148. Ko, D.C., L. Milenkovic, S. Beier, H. Manuel, J. Buchanan, and M.P. Scott (2005) Cell autonomous death of cerebellar Purkinje neurons with autophagy in Niemann-Pick Type C disease.  PLoS Genetics, 1(1):e7. [PDF reprint]

149. Huang, X., K. Suyama, J. Buchanan, A.J. Zhu, and M.P. Scott (2005) A Drosophila model of the Niemann-Pick Type C lysosomal storage disease: dnpc1a is required for molting and sterol homeostasis. Development, 132: (22):5115-24. [PDF reprint]

150. Zhang, X., C.-C. Chen, R.W. Bernstein, S. Zappe, M.P. Scott, and O. Solgaard (2005) Microoptical characterization and modeling of positioning forces on Drosophila embryos self-assembled in two-dimensional arrays.  J. Microelectromechanical Syst. 14: 1187-1197. [PDF reprint]

151. Zhang, X., M.P. Scott, C.F. Quate, O. Solgaard (2006) Microoptical characterization of piezoelectric vibratory microinjections in Drosophila embryos for genome-wide RNAi screen. J. Microelectromechanical Syst. 15: 277-286. [PDF reprint]

152. Corcoran, R.B. and M.P. Scott (2006) Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Nat. Acad. Sci. U.S.A. 103: 8408-8413. [PDF reprint]

153. Zappe, S., M. Fish, M.P. Scott, O. Solgaard (2006) Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab Chip 6: 1012-1019. [PDF reprint]

154. Trowbridge, J.J., M.P. Scott, and M. Bhatia (2006) Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc. Nat. Acad. Sci. U.S.A. 103: 14134-14139. [PDF reprint]

155. Zimmermann, G., E. E. Furlong, K. Suyama, and M.P. Scott (2006) Mes2, a MADF-containing transcription factor essential for Drosophila development. Devel. Dynamics 235: 3387-3395. [PDF reprint]

156. Deans , R., Antic, D., Suyama, K., Scott, M.P., Axelrod, J.D. and L.V. Goodrich. (2007) Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci. 27(12):3139-47. [PDF reprint]

157. Xing, Y., Ouyang, Z., Kapur, K., Scott, M.P. and W.H. Wong. (2007) Assessing the Conservation of Mammalian Gene Expression Using High-density Exon Arrays. Mol Biol Evol. 24(6):1283-1285. [PDF reprint]

158. Zhang, J., Schulze, K.L., Hiesinger, P.R., Suyama, K., Wang, S., Fish, M., Acar, M., Hoskins, R.A., Bellen, H.J. and M.P. Scott. 31 Flavors of Drosophila Rab Proteins. Genetics. 176(2):1307-22. [PDF reprint]

159. Lodish, H.F., A.J. Berk, C.A. Kaiser, M. Krieger, M.P. Scott, H. Ploegh, and A. Bretscher (2007) Molecular Cell Biology, 6th Ed., W.H. Freeman & Co., New York.

160. Rohatgi, R., L. Milenkovic, and M.P. Scott (2007) Patched1 regulates Hedgehog signaling at the primary cilium. Science, 317(5836):372-6. [PDF reprint]

161. Scott, M.P. (2007) Developmental genomics of the most dangerous animal. Proc. Nat. Acad. Sci. U.S.A., 104(29):11865-6. [PDF reprint]

162. Rohatgi, R., and M.P. Scott (2007) Patching the gaps in Hedgehog signaling. Nature Cell Biology, 9:1005-1009. [PDF reprint]

163. Corona, D.F.V., G. Siriaco, J.A. Armstrong, N. Snarskaya, S.A. McClymont, M.P. Scott, and J.W. Tamkun (2007) ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biology, 5(9):e232. [PDF reprint]

164. Huang, X., J.T. Warren, J. Buchanan, L.I. Gilbert, and M.P. Scott (2007) Drosophila Niemann-Pick C2 genes control sterol homeostasis and steroid biosynthesis: A model of human neurodegenerative disease. Development 134: 3733-3742. [PDF reprint]

165. Lelievre, V., A. Seksenyan, H. Nobuta, W. Yong, S. Chith, H. Dong, A. Flores, L.M. Liau, H.I. Kornblum, M.P. Scott, and J.A. Waschek (2008) Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Devel Biol. 313: 359-370. [PDF reprint]

166. Kaplan, D.D., G. Zimmermann, K. Suyama, T. Meyer, and M.P. Scott (2008) A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Devel. 22(14):1877-93. [PDF reprint]

167. Rohatgi, R. and M.P. Scott (2008) Cell biology: Arrestin' movement in cilia. Science, 320(5884):1726-7. [PDF reprint]

168. Corcoran RB, Bachar Raveh T, Barakat MT, Lee EY, and Scott MP. (2008) Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res. 68(21):8788-95. [PDF reprint]

169. Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, and El-Shanti HI. (2008) A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 83(5):572-81. [PDF reprint]

170. Taniguchi E, Cho MJ, Arenkiel BR, Hansen MS, Rivera OJ, McCleish AT, Qualman SJ, Guttridge DC, Scott MP, Capecchi MR, and Keller C. (2009) Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Feb 11. [PDF reprints]

171. Rohatgi R, Milenkovic L, Corcoran RB, and Scott MP. (2009) Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. [PDF reprints]

172. Chen H, Ma Z, Liu Z, Tian Y, Xiang Y, Wang C, Scott MP, and Huang X. (2009) Case studies of ends-out gene targeting in Drosophila. Genesis. 2009 Mar 19. [PDF reprints]

173. Zimmermann*, G., L. Wang*, A.G. Vaughan*, D.S. Manoli, F. Zhang, K. Deisseroth, B.S. Baker, and M.P. Scott (2009) Manipulation of an innate escape respone in Drosophila: photoexcitation of acj6 neurons induces the escape response. *Co-first authors. PLoS One 4: e5100. [PDF reprints]

174. Zhang, J., M. Fonovic, K. Suyama, M. Bogyo, and M.P. Scott (2009) Rab35 controls actin bundling by recruiting Fascin as an effector protein. Science 325: 1250-1254. [PDF reprints]

175. Milenkovic, L., M.P. Scott, and R. Rohatgi (2009) Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biology 187: 365-374. [PDF Reprints]

176. Barakat, M. and M.P. Scott (2009) Tail wags dog: Primary cilia and tumorigenesis. Cancer Cell 16: 276-277. [PDF Reprints]


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