Publications

Publications

  • Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder. JCI insight Maloney, E. M., Busque, V. A., Hui, S. T., Toh, J., Fernandez-Vina, M., Krams, S. M., Esquivel, C. O., Martinez, O. M. 2020; 5 (6)

    Abstract

    Epstein-Barr Virus (EBV) is a ubiquitous virus linked to a variety of lymphoid and epithelial malignancies. In solid organ and hematopoietic stem cell transplant recipients, EBV is causally associated with posttransplant lymphoproliferative disorder (PTLD), a group of heterogeneous lymphoid diseases. EBV+ B cell lymphomas that develop in the context of PTLD are generally attributed to the immunosuppression required to promote graft survival, but little is known regarding the role of EBV genome diversity in the development of malignancy. We deep-sequenced the EBV genome from the peripheral blood of 18 solid organ transplant recipients, including 6 PTLD patients. Sequences from 6 EBV+ spontaneous lymphoblastoid B cell lines (SLCL) were similarly analyzed. The EBV genome from PTLD patients had a significantly greater number of variations than EBV from transplant recipients without PTLD. Importantly, there were 15 nonsynonymous variations, including 8 in the latent cycle gene EBNA3C that were associated with the development of PTLD. One of the nonsynonymous variations in EBNA3C is located within a previously defined T cell epitope. These findings suggest that variations in the EBV genome can contribute to the pathogenesis of PTLD.

    View details for DOI 10.1172/jci.insight.131644

    View details for PubMedID 32213705

  • Epstein-Barr Virus Latent Membrane Protein 1 Regulates Host B Cell MicroRNA-155 and Its Target FOXO3a via PI3K p110 alpha Activation FRONTIERS IN MICROBIOLOGY Hatton, O., Smith, M. M., Alexander, M., Mandell, M., Sherman, C., Stesney, M. W., Hui, S., Dohrn, G., Medrano, J., Ringwalt, K., Harris-Arnold, A., Maloney, E. M., Krams, S. M., Martinez, O. M. 2019; 10
  • Differential role of natural killer group 2D in recognition and cytotoxicity of hepatocyte-like cells derived from embryonic stem cells and induced pluripotent stem cells AMERICAN JOURNAL OF TRANSPLANTATION Cisneros, T., Dillard, D. W., Qu, X., Arredondo-Guerrero, J., Castro, M., Schaffert, S., Martin, R., Esquive, C. O., Krams, S. M., Martinez, O. M. 2019; 19 (6): 1652–62

    View details for DOI 10.1111/ajt.15217

    View details for Web of Science ID 000469275600010

  • Dual blockade of the PI3K/Akt/mTOR pathway inhibits posttransplant Epstein-Barr virus B cell lymphomas and promotes allograft survival AMERICAN JOURNAL OF TRANSPLANTATION Sang, A. X., McPherson, M. C., Ivison, G. T., Qu, X., Rigdon, J., Esquivel, C. O., Krams, S. M., Martinez, O. M. 2019; 19 (5): 1305–14

    View details for DOI 10.1111/ajt.15216

    View details for Web of Science ID 000471342300010

  • Characterization of genomic alterations in EBV plus PTLD Krams, S. M., Arvedson, M., Maloney, E., Balachandran, Y., McPherson, M., Boyd, S. D., Esquivel, C. O., Martinez, O. M. WILEY. 2019

Publications

  • The immune roadmap for understanding multi-system inflammatory syndrome in children: opportunities and challenges. Nature medicine Martinez, O. M., Bridges, N. D., Goldmuntz, E., Pascual, V. 2020

    View details for DOI 10.1038/s41591-020-1140-9

    View details for PubMedID 33139949

  • Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation AMERICAN JOURNAL OF TRANSPLANTATION Shaw, B. I., Lee, H., Chan, C., Ettenger, R., Grimm, P., Pearl, M., Reed, E. F., Robien, M. A., Sarwal, M., Stempora, L., Warshaw, B., Zhao, C., Martinez, O. M., Kirk, A. D., Chambers, E. T. 2020

    View details for DOI 10.1111/ajt.16263

    View details for Web of Science ID 000568268300001

  • Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder. JCI insight Maloney, E. M., Busque, V. A., Hui, S. T., Toh, J., Fernandez-Vina, M., Krams, S. M., Esquivel, C. O., Martinez, O. M. 2020; 5 (6)

    Abstract

    Epstein-Barr Virus (EBV) is a ubiquitous virus linked to a variety of lymphoid and epithelial malignancies. In solid organ and hematopoietic stem cell transplant recipients, EBV is causally associated with posttransplant lymphoproliferative disorder (PTLD), a group of heterogeneous lymphoid diseases. EBV+ B cell lymphomas that develop in the context of PTLD are generally attributed to the immunosuppression required to promote graft survival, but little is known regarding the role of EBV genome diversity in the development of malignancy. We deep-sequenced the EBV genome from the peripheral blood of 18 solid organ transplant recipients, including 6 PTLD patients. Sequences from 6 EBV+ spontaneous lymphoblastoid B cell lines (SLCL) were similarly analyzed. The EBV genome from PTLD patients had a significantly greater number of variations than EBV from transplant recipients without PTLD. Importantly, there were 15 nonsynonymous variations, including 8 in the latent cycle gene EBNA3C that were associated with the development of PTLD. One of the nonsynonymous variations in EBNA3C is located within a previously defined T cell epitope. These findings suggest that variations in the EBV genome can contribute to the pathogenesis of PTLD.

    View details for DOI 10.1172/jci.insight.131644

    View details for PubMedID 32213705

  • Epstein-Barr Virus Latent Membrane Protein 1 Regulates Host B Cell MicroRNA-155 and Its Target FOXO3a via PI3K p110 alpha Activation FRONTIERS IN MICROBIOLOGY Hatton, O., Smith, M. M., Alexander, M., Mandell, M., Sherman, C., Stesney, M. W., Hui, S., Dohrn, G., Medrano, J., Ringwalt, K., Harris-Arnold, A., Maloney, E. M., Krams, S. M., Martinez, O. M. 2019; 10
  • Evaluating for Human Herpesvirus 6 in the Liver Explants of Children With Liver Failure of Unknown Etiology JOURNAL OF INFECTIOUS DISEASES Yang, C. H., Sahoo, M. K., Fitzpatrick, M., Lau, A. H., Pinsky, B. A., Martinez, O. M. 2019; 220 (3): 361–69