Publications

2017

Swami S, Johnson J, Bettinson LA, Kimura T, Zhu H, Albertelli MA, Johnson RW, Wu JY. Prevention of breast cancer skeletal metastases with parathyroid hormone. JCI Insight 2017, in press. PMID: 28878134.

Chubb R, Oh JB, Riley AK, Kimura T, Wu SM, Wu JY. In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments. Stem Cells 2017, 35:2150-2159. PMID: 28741855.    

Valderrabano RJ, Lee JS, Lui LY, Hoffman AR, Cummings SR, Orwoll ES, Wu JY, for the Osteoporotic Fractures in Men (MrOS) Study Research Group. Older men with anemia have increased fracture risk independent of bone mineral density. Journal of Clinical Endocrinology and Metabolism 2017, 102:2199-2206. PMID: 28368469

Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan YQ, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru J, Wu JY, Chiba S, Negrin R. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. Nature Communications 2017, 8:15068. PMID: 28485401.    

Ramaswamy G, Kim H, Zhang D, Lounev V, Wu JY, Choi Y, Kaplan FS, Pignolo RJ, Shore EM. Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways. Scientific Reports 2017, 7:45140. PMID: 28338087.    

Fan Y, Hanai J, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metabolism 2017, 25:661-72. PMID: 28162969.    

Chaudhary N1, Lee JS, Wu JY, Tharin S. Evidence for use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients. World Neurosurgery 2017, 100:551-6. PMID: 27923758.    

Valerrábano RJ, Lui LY, Lee J, Cummings SR, Orwoll ES, Hoffman AR, Wu JY, for the Osteoporotic Fractures in Men (MrOS) Study Research Group. Bone density loss is associated with blood cell counts. Journal of Bone and Mineral Research 2017, 32:212-20. PMID: 27653240.    

 

2016

Wein MN, Liang Y, Goransson O, Sundberg T, Wang J, Williams EA, O'Meara M, Govea N, Beqo B, Nishimori S, Nagano K, Brooks D, Martins J, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier R, Baron R, Bouxsein M, Gardella T, Divieti Pajevic P, Gray N, Kronenberg HM. Salt Inducible Kinases (SIKs) control osteocyte responses to parathyroid hormone. Nature Communications 2016, 7:13176. PMID: 27759007.    

Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia A. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nature Cell Biology 2016, 18:1078-89. PMID: 27642788.

Valenzuela A, Baron M, the Canadian Scleroderma Research Group, Herrick AL, Proudman S, Stevens W, the Australian Scleroderma Interest Group, Rodriguez-Reyna TS, Vacca A, Medsger TA, Hinchcliff M, Hsu V, Wu JY, Fiorentino D, Chung L. Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium Study. Seminars in Arthritis and Rheumatism 2016, 46:344-49. PMID: 27371996.

Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY. Loss of Gsα in the postnatal skeleton leads to low bone mass and a blunted response to anabolic parathyroid hormone therapy. Journal of Biological Chemistry 2016, 291:1631-42. PMID: 26598522.

 

2015

Wu JY. Pluripotent stem cells and skeletal regeneration – promise and potential [review]. Current Osteoporosis Reports, 2015, 13:342-350. PMID: 26260198.

Panaroni C, Fulzele K, Saini V, Chubb R, Divieti Pajevic P, Wu JY. PTH signaling in osteoprogenitors is essential for B lymphocyte differentiation and mobilization. The Journal of Bone and Mineral Research 2015, 30:2273-86. PMID: 26191777.

Green AC, Poulton IJ, Vrahnas C, Hausler KD, Walkley CR, Wu JY, Martin TJ, Gillespie MT, Chandraratna RAS, Quinn JMW, Sims NA, and Purton LE. RARγ is a negative regulator of osteoclastogenesis. The Journal of Steroid Biochemistry and Molecular Biology 2015, 150:46-53. PMID: 25800721.

Yu V, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers M, Wu JY, Zhou L, Rajagopal J, Kronenberg H, Baron R, and Scadden D. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. Journal of Experimental Medicine 2015, 212:759-75. PMID: 25918341.

Yuan K, Orcholski M, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, and de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. American Journal of Pathology 2015: 185:69-84. PMID: 25447046.

 

2014

Tan SH, Senarath-Yapa K, Chung MT, Longaker MT, Wu JY, and Nusse R. Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proceedings of the National Academy of Sciences 2014, 111:E5262-71. PMID: 25422448.

Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Divieti Pajevic P, Kronenberg HM, and Wu JY. Loss of Gsa early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors. Journal of Bone and Mineral Research 2014, 29:2414-26. PMID: 24806274.

Yu EW, Kumbhani R, Siwila-Sackman E, Delelys M, Preffer F, Leder BZ and Wu JY. Teriparatide (PTH 1-34) treatment increases peripheral hematopoietic stem cells in postmenopausal women. Journal of Bone and Mineral Research 2014, 29:1380-6. PMID: 24420643.

Pellicelli M, Miller J, Arabian A, Gauthier C, Akhouayri O, Wu JY, Kronenberg HM, and St-Arnaud R. The PTH-Gαs-PKA cascade controls αNAC localization to regulate bone mass. Molecular and Cellular Biology 2014, 34:1622-33. PMID: 24550008.

Panaroni C, Tzeng YS, Saeed H and Wu JY. Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches. Current Osteoporosis Reports, 2014, 12:22-32. PMID: 24477415.

 

2013

Fulzele F, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden D, and Divieti Pajevic P. Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Blood 2013, 121:930-9. PMID: 23160461

Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine 2013, 19:1513-7. PMID: 24162813.

Panaroni C and Wu JY. Interactions between B lymphocytes and the osteoblast lineage in bone marrow. Calcified Tissue International, 2013, 93:261-268. PMID: 23839529.

Provot S, Schipani E, Wu JY, Kronenberg H. Development of the skeleton. In: Marcus R, Feldman D, Dempster D, Luckey M, Cauley JA, editors. Osteoporosis, 4th Edition. Boston: Academic Press, 2013.

 

2011

Mariot V, Wu JY, Aydin C, Mantovani G, Mahon MJ, Linglart A, Bastepe M. Potent constitutive cyclic AMP-generating activity of XLas implicates the imprinted GNAS product in the pathogenesis of McCune-Albright Syndrome and fibrous dysplasia of bone. Bone 2011, 48:312-20. PMID: 20887824.

Wu JY*, Aarnisalo P, Bastepe M, Sinha P, Purton LE, Chen M, Poulton IJ, Sims NA, Weinstein LS, Kronenberg HM. Gsa enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. Journal of Clinical Investigation 2011, 121:3492-504. (*co-corresponding author) PMID: 21804192.

Wu JY and Kronenberg HM. The role of bone cells in establishing the hematopoietic stem cell niche. In: Lorenzo J, Choi YW, Horowitz M, and Takayanagi H, editors. Osteoimmunology: Interactions of the Immune and Skeletal Systems, Boston: Academic Press, 2011. p. 81-99.

 

2010

Wu JY. Clarifying the contributions of distinct mesenchymal populations in supporting hematopoiesis. IBMS BoneKEy 2010, 7:369-372.

 

2009

Wu JY, Scadden DT, Kronenberg HM. The role of the osteoblast lineage in the bone marrow hematopoietic niches. Journal of Bone and Mineral Research 2009, 24:759-764. PMID: 19257832.

 

2008

Wu JY*, Purton LE*, Rodda SF, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM. Osteoblastic regulation of B lymphopoiesis is mediated by Gsa-dependent signaling pathways. Proceedings of the National Academy of Sciences 2008, 105:16976-81. (*equal contribution) PMID: 18957542.

Provot S, Schipani E, Wu J, Kronenberg H. Development of the skeleton. In: Marcus R, Feldman D, Nelson DA, Rosen CJ, editors. Osteoporosis, 3rd Edition. Boston: Academic Press, 2008. p. 241-269.

 

2001

Wu JY, Ribar TJ, Means AR. Spermatogenesis and the regulation of Ca2+-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. Molecular and Cellular Biology 2001, 21:6066-70. PMID: 11486043.

 

2000

Wu JY, Means AR. Ca2+/Calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. Journal of Biological Chemistry 2000; 275:7994-9. PMID: 10713118.

Wu JY, Ribar TJ, Cummings DE, Burton KA, McKnight GS, Means AR. Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Ca2+/calmodulin-dependent protein kinase IV. Nature Genetics 2000; 25:448-52. PMID: 10932193.

Wu JY, Gonzalez-Robayna IJ, Richards JS, Means AR. Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. Endocrinology 2000; 141:4777-83. PMID: 11108293.

 

1999

Wu JY. Pharmacology. In: Yeh B, Wu SM, Flynn M, Liao L, Biswas SS, Paydarfar JA, Bulsara KR, editors. Crashing the boards: a user friendly study guide for the USMLE step 1. 2nd Edition. Philadelphia: Lippincott Williams and Wilkins, 1999. p. 31-47.