As a physician scientist with a clinical focus on osteoporosis, my laboratory focuses on the mechanisms guiding the differentiation of mesenchymal stem cells, and how mesenchymal lineages support hematopoiesis in the bone marrow. In particular we are interested in the pathways that govern the differentiation of mesenchymal progenitors into osteoblast and adipocyte lineages, using genetically modified mice and lineage tracing techniques in vivo. We are also studying the role of the osteoblast niche in supporting hematopoietic stem cell and B lymphocyte development, in both animal models as well as translational studies in humans. Finally, my laboratory is using induced pluripotent stem cells to study osteoblast differentiation in a skeletal complementation model in vivo.