Webfigure 2. Continued correlation of mRNA with protein expression by immunohistochemistry. Messenger RNA expression for genes SPARC (osteonectin), aldo-ketoreductase family 1, C4 and solute carrier family 9, isoform 3 regulatory factor 1 (SLC9A3R1). Immunohistochemical stains for each of these genes are shown below the mRNA data. Notice strong SPARC expression in the glomerular podocytes. Aldo-ketoreductase is expressed in collecting ducts and Henle's loops. SLC9A3R1 is strongly expressed in proximal tubules but not in glomeruli.