Featured Publications

 

 

All Publications

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Qin EY, Cooper DD, Abbott KL, Lennon J, Nagaraja S, Mackay A, Jones C, Vogel H, Jackson PK, Monje M.

Cell. 2017 Aug 24;170(5):845-859.e19. doi: 10.1016/j.cell.2017.07.016. Epub 2017 Aug 17.

PMID: 28823557

 

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK.

Dev Cell. 2017 Jul 10;42(1):22-36.e12. doi: 10.1016/j.devcel.2017.05.016. Epub 2017 Jun 15.

PMID: 28625565

 

 

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

Li B, Ding S, Feng N, Mooney N, Ooi YS, Ren L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, Greenberg HB.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3642-E3651. doi: 10.1073/pnas.1619266114. Epub 2017 Apr 17.

PMID: 28416666

 

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex.

Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB.

PLoS Pathog. 2016 Oct 5;12(10):e1005929. doi: 10.1371/journal.ppat.1005929. eCollection 2016 Oct.

PMID: 27706223

 

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

Boudreau A, Purkey HE, Hitz A, Robarge K, Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, Pusapati R, Ma S, Salphati L, Pang J, Zhou A, Lai T, Li Y, Chen Z, Wei B, Yen I, Sideris S, McCleland M, Firestein R, Corson L, Vanderbilt A, Williams S, Daemen A, Belvin M, Eigenbrot C, Jackson PK, Malek S, Hatzivassiliou G, Sampath D, Evangelista M, O'Brien T.

Nat Chem Biol. 2016 Oct;12(10):779-86. doi: 10.1038/nchembio.2143. Epub 2016 Aug 1.

PMID: 27479743

 

Corrigendum: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ; University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB.

Nat Genet. 2016 Jul 27;48(8):970. doi: 10.1038/ng0816-970b. No abstract available. 

PMID: 27463398

 

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ; University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB.

Nat Genet. 2016 Jun;48(6):648-56. doi: 10.1038/ng.3558. Epub 2016 May 9.

PMID: 27158779

 

Cell biology: Calcium contradictions in cilia.

Norris DP, Jackson PK.

Nature. 2016 Mar 31;531(7596):582-3. doi: 10.1038/nature17313. Epub 2016 Mar 23. No abstract available. 

PMID: 27007852

 

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.

Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S.

J Cell Biol. 2016 Mar 28;212(7):861-75. doi: 10.1083/jcb.201506132. Epub 2016 Mar 21.

PMID: 27002170 

 

p73 and FoxJ1: Programming Multiciliated Epithelia.

Jackson PK, Attardi LD.

Trends Cell Biol. 2016 Apr;26(4):239-40. doi: 10.1016/j.tcb.2016.03.001. Epub 2016 Mar 14.

PMID: 26988441

 

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling.

Hilgendorf KI, Johnson CT, Jackson PK.

Curr Opin Cell Biol. 2016 Apr;39:84-92. doi: 10.1016/j.ceb.2016.02.008. Epub 2016 Feb 27. Review.

PMID: 26926036

 

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ.

Cell Cycle. 2015;14(7):1116-25. doi: 10.4161/15384101.2014.985066.

PMID: 25830415

 

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ.

Nat Cell Biol. 2015 Apr;17(4):531. doi: 10.1038/ncb3155. No abstract available. 

PMID: 25812525

 

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ.

Nat Cell Biol. 2015 Mar;17(3):228-240. doi: 10.1038/ncb3109. Epub 2015 Feb 16. Erratum in: Nat Cell Biol. 2015 Apr;17(4):531

PMID: 25686250 

 

3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders.

Giles RH, Ajzenberg H, Jackson PK.

Nat Protoc. 2014 Dec;9(12):2725-31. doi: 10.1038/nprot.2014.181. Epub 2014 Oct 30.

PMID: 25356583

 

Regulating microtubules and genome stability via the CUL7/3M syndrome complex and CUL9.

Jackson PK.

Mol Cell. 2014 Jun 5;54(5):713-5. doi: 10.1016/j.molcel.2014.05.024.

PMID: 24905004

 

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.

Loktev AV, Jackson PK.

Cell Rep. 2013 Dec 12;5(5):1316-29. doi: 10.1016/j.celrep.2013.11.011. Epub 2013 Dec 5.

PMID: 24316073

 

Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death.

Del Nagro CJ, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, Zha J, Jackson PK, O'Brien T.

Cell Cycle. 2014;13(2):303-14. doi: 10.4161/cc.27055. Epub 2013 Feb 1.

PMID: 24247149

 

Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.

Xiao Y, Elkins K, Durieux JK, Lee L, Oeh J, Yang LX, Liang X, DelNagro C, Tremayne J, Kwong M, Liederer BM, Jackson PK, Belmont LD, Sampath D, O'Brien T.

Neoplasia. 2013 Oct;15(10):1151-60.

PMID: 24204194 

 

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Thomas S, Wright KJ, Le Corre S, Micalizzi A, Romani M, Abhyankar A, Saada J, Perrault I, Amiel J, Litzler J, Filhol E, Elkhartoufi N, Kwong M, Casanova JL, Boddaert N, Baehr W, Lyonnet S, Munnich A, Burglen L, Chassaing N, Encha-Ravazi F, Vekemans M, Gleeson JG, Valente EM, Jackson PK, Drummond IA, Saunier S, Attié-Bitach T.

Hum Mutat. 2014 Jan;35(1):137-46.

PMID: 24166846

 

Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor.

Xiao Y, Ramiscal J, Kowanetz K, Del Nagro C, Malek S, Evangelista M, Blackwood E, Jackson PK, O'Brien T.

Mol Cancer Ther. 2013 Nov;12(11):2285-95. doi: 10.1158/1535-7163.MCT-13-0404. Epub 2013 Sep 13.

PMID: 24038068

 

Nek8 couples renal ciliopathies to DNA damage and checkpoint control.

Jackson PK.

Mol Cell. 2013 Aug 22;51(4):407-8. doi: 10.1016/j.molcel.2013.08.013.

PMID: 23973371

 

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Magnaghi P, D'Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Cervi G, Casale E, Xiao Y, Wong C, Anderson DJ, Galvani A, Donati D, O'Brien T, Jackson PK, Isacchi A.

Nat Chem Biol. 2013 Sep;9(9):548-56. doi: 10.1038/nchembio.1313. Epub 2013 Jul 28.

PMID: 23892893

 

Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900.

Blackwood E, Epler J, Yen I, Flagella M, O'Brien T, Evangelista M, Schmidt S, Xiao Y, Choi J, Kowanetz K, Ramiscal J, Wong K, Jakubiak D, Yee S, Cain G, Gazzard L, Williams K, Halladay J, Jackson PK, Malek S.

Mol Cancer Ther. 2013 Oct;12(10):1968-80. doi: 10.1158/1535-7163.MCT-12-1218. Epub 2013 Jul 19.

PMID: 23873850 

 

Cilia - the prodigal organelle.

Beales P, Jackson PK.

Cilia. 2012 Apr 25;1(1):1. doi: 10.1186/2046-2530-1-1. No abstract available. 

PMID: 23351984

 

Cilia develop long-lasting contacts, with other cilia.

Jackson PK.

Cilia. 2012 May 4;1(1):5. doi: 10.1186/2046-2530-1-5. No abstract available. 

PMID: 23351843

 

 

Cilia, tubby mice, and obesity.

Mukhopadhyay S, Jackson PK.

Cilia. 2013 Jan 3;2:1. doi: 10.1186/2046-2530-2-1. eCollection 2013.

PMID: 23351214

 

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK.

Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026.

PMID: 23332756 

 

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3.

Lahtela J, Corson LB, Hemmes A, Brauer MJ, Koopal S, Lee J, Hunsaker TL, Jackson PK, Verschuren EW.

Cell Cycle. 2013 Feb 15;12(4):625-34. doi: 10.4161/cc.23515. Epub 2013 Jan 16.

PMID: 23324396

 

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

Polucci P, Magnaghi P, Angiolini M, Asa D, Avanzi N, Badari A, Bertrand J, Casale E, Cauteruccio S, Cirla A, Cozzi L, Galvani A, Jackson PK, Liu Y, Magnuson S, Malgesini B, Nuvoloni S, Orrenius C, Sirtori FR, Riceputi L, Rizzi S, Trucchi B, O'Brien T, Isacchi A, Donati D, D'Alessio R.

J Med Chem. 2013 Jan 24;56(2):437-50. doi: 10.1021/jm3013213. Epub 2013 Jan 4.

PMID: 23245311

 

TTBK2 kinase: linking primary cilia and cerebellar ataxias.

Jackson PK.

Cell. 2012 Nov 9;151(4):697-9. doi: 10.1016/j.cell.2012.10.027.

PMID: 23141531

 

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5299-304. doi: 10.1073/pnas.1116510109. Epub 2012 Mar 19.

PMID: 22431598

 

 

The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.

PMID: 22153075 

 

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK.

Genes Dev. 2011 Nov 15;25(22):2347-60. doi: 10.1101/gad.173443.111.

PMID: 22085962

 

Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.

Anderson DJ, Durieux JK, Song K, Alvarado R, Jackson PK, Hatzivassiliou G, Ludlam MJ.

PLoS One. 2011;6(8):e22607. doi: 10.1371/journal.pone.0022607. Epub 2011 Aug 4.

PMID: 21829637

 

The tubby family proteins.

Mukhopadhyay S, Jackson PK.

Genome Biol. 2011 Jun 28;12(6):225. doi: 10.1186/gb-2011-12-6-225. Review.

 

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM.

Mol Cell. 2011 May 20;42(4):511-23. doi: 10.1016/j.molcel.2011.03.027.

PMID: 21596315 

 

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK.

Cell. 2011 May 13;145(4):513-28. doi: 10.1016/j.cell.2011.04.019.

PMID: 21565611

 

Do cilia put brakes on the cell cycle?

Jackson PK.

Nat Cell Biol. 2011 Apr;13(4):340-2. doi: 10.1038/ncb0411-340.

PMID: 21460803

 

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM.

Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Erratum in: Nature. 2011 Jul 7;475(7354):122. 

PMID: 21368834

 

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64. doi: 10.1073/pnas.1018823108. Epub 2011 Jan 27.

PMID: 21273506

 

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation.

Chu CW, Hou F, Zhang J, Phu L, Loktev AV, Kirkpatrick DS, Jackson PK, Zhao Y, Zou H.

Mol Biol Cell. 2011 Feb 15;22(4):448-56. doi: 10.1091/mbc.E10-03-0203. Epub 2010 Dec 22.

PMID: 21177827

 

APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C.

Cell Cycle. 2010 Oct 1;9(19):3956-64. Epub 2010 Oct 26.

PMID: 20948288 

 

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK.

Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210.

PMID: 20889716

 

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.

Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, Coene KL, Estrada-Cuzcano A, Collin RW, McLaughlin HM, Held S, Kasanuki JM, Ramaswami G, Conte J, Lopez I, Washburn J, Macdonald J, Hu J, Yamashita Y, Maher ER, Guay-Woodford LM, Neumann HP, Obermüller N, Koenekoop RK, Bergmann C, Bei X, Lewis RA, Katsanis N, Lopes V, Williams DS, Lyons RH, Dang CV, Brito DA, Dias MB, Zhang X, Cavalcoli JD, Nürnberg G, Nürnberg P, Pierce EA, Jackson PK, Antignac C, Saunier S, Roepman R, Dollfus H, Khanna H, Hildebrandt F.

Nat Genet. 2010 Oct;42(10):840-50. doi: 10.1038/ng.662. Epub 2010 Sep 12.

PMID: 20835237

 

A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress.

Peterson D, Lee J, Lei XC, Forrest WF, Davis DP, Jackson PK, Belmont LD.

Cancer Res. 2010 Aug 1;70(15):6325-35. doi: 10.1158/0008-5472.CAN-10-0015. Epub 2010 Jul 20.

PMID: 20647325

 

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.

O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Khanna H, Katsanis N, Hildebrandt F.

J Clin Invest. 2010 Mar;120(3):791-802. doi: 10.1172/JCI40076. Epub 2010 Feb 22. Erratum in: J Clin Invest. 2010 Apr;120(4):1362. Jackson, Peter [corrected to Jackson, Peter K]. 

PMID: 20179356 

 

A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles.

Torres JZ, Ban KH, Jackson PK.

Mol Biol Cell. 2010 Mar 15;21(6):897-904. doi: 10.1091/mbc.E09-07-0598. Epub 2010 Jan 20.

PMID: 20089842

 

Navigating the deubiquitinating proteome with a CompPASS.

Jackson PK.

Cell. 2009 Jul 23;138(2):222-4. doi: 10.1016/j.cell.2009.07.008. Erratum in: Cell. 2009 Sep 18;138(6):1247. 

PMID: 19632171

 

Biochemical analysis of the Anaphase Promoting Complex: activities of E2 enzymes and substrate competitive (pseudosubstrate) inhibitors.

Summers MK, Jackson PK.

Methods Mol Biol. 2009;545:313-30. doi: 10.1007/978-1-60327-993-2_20.

PMID: 19475398

 

High-throughput generation of tagged stable cell lines for proteomic analysis.

Torres JZ, Miller JJ, Jackson PK.

Proteomics. 2009 May;9(10):2888-91. doi: 10.1002/pmic.200800873.

PMID: 19405035

 

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV.

Dev Cell. 2008 Dec;15(6):854-65. doi: 10.1016/j.devcel.2008.11.001.

PMID: 19081074 

 

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

Summers MK, Pan B, Mukhyala K, Jackson PK.

Mol Cell. 2008 Aug 22;31(4):544-56. doi: 10.1016/j.molcel.2008.07.014.

PMID: 18722180

 

The hunt for cyclin.

Jackson PK.

Cell. 2008 Jul 25;134(2):199-202. doi: 10.1016/j.cell.2008.07.011. Erratum in: Cell. 2008 Oct 17;135(2):366. 

PMID: 18662532

 

Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.

Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S.

Mol Biol Cell. 2008 Aug;19(8):3536-43. doi: 10.1091/mbc.E08-04-0417. Epub 2008 Jun 11.

PMID: 18550795

 

Stopping replication, at the beginning.

Jackson PK.

Nat Chem Biol. 2008 Jun;4(6):331-2. doi: 10.1038/nchembio0608-331. No abstract available. 

PMID: 18488006

 

 

The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.

Berdougo E, Nachury MV, Jackson PK, Jallepalli PV.

Cell Cycle. 2008 May 1;7(9):1184-90. Epub 2008 Feb 13.

PMID: 18418058

 

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma.

Gütgemann I, Lehman NL, Jackson PK, Longacre TA.

Mod Pathol. 2008 Apr;21(4):445-54. doi: 10.1038/modpathol.3801022. Epub 2008 Jan 18.

PMID: 18204430 

 

Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.

Wu JQ, Hansen DV, Guo Y, Wang MZ, Tang W, Freel CD, Tung JJ, Jackson PK, Kornbluth S.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16564-9. Epub 2007 Sep 19.

PMID: 17881560

 

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

Verschuren EW, Ban KH, Masek MA, Lehman NL, Jackson PK.

Mol Cell Biol. 2007 Nov;27(22):7955-65. Epub 2007 Sep 17.

PMID: 17875940

 

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.

Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C.

Cell. 2007 Aug 24;130(4):611-23.

PMID: 17719540

 

Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).

Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK, Reed SI.

J Cell Biol. 2007 Jul 30;178(3):371-85.

PMID: 17664332 

 

The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.

Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK.

Dev Cell. 2007 Jul;13(1):29-42.

PMID: 17609108

 

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.

PMID: 17574030

 

Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.

Lehman NL, Tibshirani R, Hsu JY, Natkunam Y, Harris BT, West RB, Masek MA, Montgomery K, van de Rijn M, Jackson PK.

Am J Pathol. 2007 May;170(5):1793-805.

PMID: 17456782

 

Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis II.

Tung JJ, Padmanabhan K, Hansen DV, Richter JD, Jackson PK.

Cell Cycle. 2007 Mar 15;6(6):725-31. Epub 2007 Mar 1.

PMID: 17361107

 

Emi2 at the crossroads: where CSF meets MPF.

Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE Jr, Jackson PK.

Cell Cycle. 2007 Mar 15;6(6):732-8. Epub 2007 Mar 14.

PMID: 17361104

 

A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.

Wu Q, Guo Y, Yamada A, Perry JA, Wang MZ, Araki M, Freel CD, Tung JJ, Tang W, Margolis SS, Jackson PK, Yamano H, Asano M, Kornbluth S.

Curr Biol. 2007 Feb 6;17(3):213-24.

PMID: 17276914 

 

Putting transcription repression and protein destruction in pRb's pocket.

Verschuren EW, Jackson PK.

Dev Cell. 2007 Feb;12(2):169-70.

PMID: 17276331

 

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.

Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41. Epub 2007 Jan 17.

PMID: 17229837

 

Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).

Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J.

J Cell Biol. 2007 Jan 1;176(1):65-75. Epub 2006 Dec 26.

PMID: 17190794

 

Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis.

Madgwick S, Hansen DV, Levasseur M, Jackson PK, Jones KT.

J Cell Biol. 2006 Sep 11;174(6):791-801.

PMID: 16966421 

 

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.

Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18.

PMID: 16921029

 

Developmental neurobiology: a destructive switch for neurons.

Jackson PK.

Nature. 2006 Jul 27;442(7101):365-6. No abstract available. 

PMID: 16871201

 

Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.

Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK.

Cell Cycle. 2006 Jul;5(14):1569-73. Epub 2006 Jul 17.

PMID: 16861914

 

Climbing the Greatwall to mitosis.

Jackson PK.

Mol Cell. 2006 Apr 21;22(2):156-7.

PMID: 16630886

 

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK.

Cell. 2006 Jan 27;124(2):367-80.

PMID: 16439210

 

Dual degradation signals control Gli protein stability and tumor formation.

Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE.

Genes Dev. 2006 Feb 1;20(3):276-81. Epub 2006 Jan 18.

PMID: 16421275 

 

CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit.

Hansen DV, Tung JJ, Jackson PK.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):608-13. Epub 2006 Jan 9.

PMID: 16407128

 

Screening of tissue microarrays for ubiquitin proteasome system components in tumors.

Lehman NL, van de Rijn M, Jackson PK.

Methods Enzymol. 2005;399:334-55.

PMID: 16338367

 

Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.

Casaletto JB, Nutt LK, Wu Q, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S.

J Cell Biol. 2005 Apr 11;169(1):61-71.

PMID: 15824132

 

A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Tung JJ, Hansen DV, Ban KH, Loktev AV, Summers MK, Adler JR 3rd, Jackson PK.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4318-23. Epub 2005 Mar 7.

PMID: 15753281

 

Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes.

Tung JJ, Jackson PK.

Cell Cycle. 2005 Mar;4(3):478-82. Epub 2005 Mar 11.

 

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Hansen DV, Loktev AV, Ban KH, Jackson PK.

Mol Biol Cell. 2004 Dec;15(12):5623-34. Epub 2004 Oct 6.

PMID: 15469984 

 

Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.

Pagano M, Jackson PK.

Cell. 2004 Sep 3;118(5):535-8. Review.

PMID: 15339658

 

Human TRPC5 channel activated by a multiplicity of signals in a single cell.

Zeng F, Xu SZ, Jackson PK, McHugh D, Kumar B, Fountain SJ, Beech DJ.

J Physiol. 2004 Sep 15;559(Pt 3):739-50. Epub 2004 Jul 14. Erratum in: J Physiol. 2004 Nov 1;560(Pt 3):950. 

PMID: 15254149

 

Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division.

Kaiser BK, Nachury MV, Gardner BE, Jackson PK.

BMC Cell Biol. 2004 Jul 13;5:27.

PMID: 15251038

 

Linking tumor suppression, DNA damage and the anaphase-promoting complex.

Jackson PK.

Trends Cell Biol. 2004 Jul;14(7):331-4. Review.

PMID: 15246424

 

Can Fizzy fly solo?

Jackson PK.

Nat Cell Biol. 2003 Oct;5(10):864-5. No abstract available. 

PMID: 14523400

 

Accessory proteins for melanocortin signaling: attractin and mahogunin.

He L, Eldridge AG, Jackson PK, Gunn TM, Barsh GS.

Ann N Y Acad Sci. 2003 Jun;994:288-98. Review.

PMID: 12851328

 

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK.

Dev Cell. 2003 Jun;4(6):813-26.

PMID: 12791267 

 

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M.

Dev Cell. 2003 Jun;4(6):799-812.

PMID: 12791266

 

Spongiform degeneration in mahoganoid mutant mice.

He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS, Gunn TM.

Science. 2003 Jan 31;299(5607):710-2.

PMID: 12560552

 

Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller.

Jackson PK.

Cell. 2003 Jan 24;112(2):142-4.

PMID: 12553901

 

The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development.

Borchers AG, Hufton AL, Eldridge AG, Jackson PK, Harland RM, Baker JC.

Dev Biol. 2002 Nov 15;251(2):395-408.

PMID: 12435366 

 

Control of the centriole and centrosome cycles by ubiquitination enzymes.

Hansen DV, Hsu JY, Kaiser BK, Jackson PK, Eldridge AG.

Oncogene. 2002 Sep 9;21(40):6209-21. Review. No abstract available. 

PMID: 12214251

 

Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.

Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK.

Mol Biol Cell. 2002 Jul;13(7):2289-300.

PMID: 12134069

 

The SCF ubiquitin ligase: an extended look.

Jackson PK, Eldridge AG.

Mol Cell. 2002 May;9(5):923-5. Review.

PMID: 12049727

 

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).

Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK.

Nat Cell Biol. 2002 May;4(5):358-66.

PMID: 11988738

 

Emi1 is required for cytostatic factor arrest in vertebrate eggs.

Reimann JD, Jackson PK.

Nature. 2002 Apr 25;416(6883):850-4.

PMID: 11976684

 

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.

Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J.

Nat Cell Biol. 2002 Apr;4(4):317-22. Erratum in: Nat Cell Biol. 2006 Aug;8(8):897. 

PMID: 11901424

 

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

Reimann JD, Gardner BE, Margottin-Goguet F, Jackson PK.

Genes Dev. 2001 Dec 15;15(24):3278-85.

PMID: 11751633 

 

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases.

Jackson PK.

Genes Dev. 2001 Dec 1;15(23):3053-8. Review. No abstract available. 

PMID: 11731472

 

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication.

Furstenthal L, Swanson C, Kaiser BK, Eldridge AG, Jackson PK.

Nat Cell Biol. 2001 Aug;3(8):715-22.

PMID: 11483956

 

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK.

Cell. 2001 Jun 1;105(5):645-55.

PMID: 11389834

 

Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication.

Furstenthal L, Kaiser BK, Swanson C, Jackson PK.

J Cell Biol. 2001 Mar 19;152(6):1267-78.

PMID: 11257126

 

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.

Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD.

Trends Cell Biol. 2000 Oct;10(10):429-39. Review.

PMID: 10998601

 

Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

Swanson C, Ross J, Jackson PK.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7796-801.

PMID: 10884410 

 

Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF(Pop)-mediated proteolysis.

Wolf DA, McKeon F, Jackson PK.

Mol Gen Genet. 1999 Oct;262(3):473-80.

PMID: 10589835

 

Identification of novel F-box proteins in Xenopus laevis.

Regan-Reimann JD, Duong QV, Jackson PK.

Curr Biol. 1999 Oct 21;9(20):R762-3. No abstract available. 

PMID: 10531041

 

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

Freed E, Lacey KR, Huie P, Lyapina SA, Deshaies RJ, Stearns T, Jackson PK.

Genes Dev. 1999 Sep 1;13(17):2242-57.

PMID: 10485847

 

F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p.

Wolf DA, McKeon F, Jackson PK.

Curr Biol. 1999 Apr 8;9(7):373-6.

PMID: 10209119

 

Cyclin-dependent kinase control of centrosome duplication.

Lacey KR, Jackson PK, Stearns T.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2817-22.

PMID: 10077594 

 

Cell cycle: oiling the gears of anaphase.

Wolf DA, Jackson PK.

Curr Biol. 1998 Sep 10;8(18):R636-9. Review.

PMID: 9740795

 

Cell cycle: cull and destroy.

Jackson PK.

Curr Biol. 1996 Oct 1;6(10):1209-12. Review.

PMID: 8939566

 

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

Wen ST, Jackson PK, Van Etten RA.

EMBO J. 1996 Apr 1;15(7):1583-95.

PMID: 8612582

 

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

Jackson PK, Chevalier S, Philippe M, Kirschner MW.

J Cell Biol. 1995 Aug;130(4):755-69.

PMID: 7642695 

 

Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response.

Mattioni T, Jackson PK, Bchini-Hooft van Huijsduijnen O, Picard D.

Oncogene. 1995 Apr 6;10(7):1325-33.

PMID: 7731683

 

 

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

Chen J, Jackson PK, Kirschner MW, Dutta A.

Nature. 1995 Mar 23;374(6520):386-8.

PMID: 7885482

 

Mitosis in transition.

King RW, Jackson PK, Kirschner MW.

Cell. 1994 Nov 18;79(4):563-71. Review. No abstract available. 

PMID: 7954823

 

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity.

Van Etten RA, Jackson PK, Baltimore D, Sanders MC, Matsudaira PT, Janmey PA.

J Cell Biol. 1994 Feb;124(3):325-40. Erratum in: J Cell Biol 1994 Mar;124(5):865. 

PMID: 8294516

 

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

Jackson PK, Paskind M, Baltimore D.

Oncogene. 1993 Jul;8(7):1943-56.

PMID: 8510937

 

Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

Daley GQ, Van Etten RA, Jackson PK, Bernards A, Baltimore D.

Mol Cell Biol. 1992 Apr;12(4):1864-71.

PMID: 1549131

 

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

Mayer BJ, Jackson PK, Van Etten RA, Baltimore D.

Mol Cell Biol. 1992 Feb;12(2):609-18.

PMID: 1370711

 

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC.

Cell. 1991 Jun 28;65(7):1153-63.

PMID: 2065352

 

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

Mayer BJ, Jackson PK, Baltimore D.

Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):627-31.

PMID: 1703304