Infectious Diseases Postdocs
This profile is not available
Postdoctoral Research Fellow, Infectious Diseases
Jagadish Sundaramurthi did Ph.D. on Vaccinology in the National Institute for Research in Tuberculosis (University of Madras), Chennai. He prioritized epitopes using sequence and structure-based methods and rationally modified a few of the prioritized HIV epitopes and demonstrated stronger immune response in vitro for modified epitopes than the respective wild type epitopes against HIV-1. His findings have relevance for rational vaccine design for HIV and other infectious diseases. Further, he analyzed complete genome of Mycobacterium tuberculosis for the prioritization of antigenic proteins and identified epitopes with potential for vaccine design against TB. During his postdoctoral research in NIRT, India, Jagadish involved in the analysis of Whole Genome Sequences of Mycobacterium tuberculosis that revealed novel drug resistant mutations in M. tuberculosis from India that highlighted the challenges in rapid diagnosis of drug-resistant tuberculosis (DR-TB) in India and suggested the need for region-specific diagnostics for DR-TB. Jagadish contributed in determining the potential repurposing nature of two of the known drugs, lymecycline and cefpodoxime for both drug-sensitive and DR-TB, and developed TBDRUGS database. Further, during the same tenure, Jagadish contributed in the identification of broadly neutralizing antibodies (bNAbs) and bNAbs-specific conformational epitopes against HIV-1. His present research in the Stanford University, California, USA, is aimed at contributing in the further understanding of transmitted drug resistance in HIV-1 with potential application for rational decision making for the treatment of HIV/AIDS and expanding the Stanford HIV Drug Resistance Database that can form the basis for developing rapid diagnostics of drug resistant HIV-1. Jagadish started his research career in 2001 with an objective to understand the dynamics of HIV coreceptor expression and their natural ligands, chemokines in vivo with a long-term objective to develop chemokine receptor antagonists as drugs. He observed higher amounts of MIP-1alpha, MIP-1beta and RANTES and decreased levels of HIV coreceptors (CCR5 and CXCR4) in HIV-1-positive individuals than healthy volunteers from South India; further, he also reported high rate of hepatitis coinfection in HIV infected individuals of South India which advocated for the early diagnosis of hepatitis viruses in HIV positive person in South India; Jagadish carried out these two research programs in the Division of HIV/AIDS, Tuberculosis Research Centre (TRC, Chennai); these two findings formed his thesis for the award of the degree, M.Phil. by the University of Madras.