Health Research and Policy

Research in Progress Seminar (RIP)

Date: February 6, 2013
Time: 1:30 pm - 3:00 pm
Location: Medical School Office Building, Rm x303
Speaker: Oana Carja
PhD in Biology (CDEHA Grant Project)
Title: Studying Whole Genome Methylation Patterns in the Khomani San Populations of the Kalahari


The Khoe San hunter-gatherers of southern Africa are believed to be one of the world's most ancient populations based on their high genetic diversity and low levels of LD. Phenotypically, the Khomani Bushmen have a range of lighter skin pigmentations, intermediate between European and central African populations, as well as a typically shorter stature.

During the past several years, researchers in the Feldman and Bustamante labs have collected genetic and phenotypic information from the Khomani Bushmen. Moreover, we methyl-typed these individuals at over 400,000 CpGs sites as well as genotyped them at over 300,000 SNP sites.

In order to better understand the epigenetic contribution of DNA methylation to skin color, we use this data set to study genome-wide methylation profiles for skin pigmentation. We also study the relationship of DNA methylation and age in these individuals.

Studies like this can help us better understand the role of DNA methylation in different phenotypes and also its changing patterns over the lifetime of an individual.

Please note: All research in progress seminars are off-the-record. Any information about methodology and/or results are embargoed until publication.
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