Webster CM, Kelly S, Koike MA, Chock V, Giffard RG, Yenari MA. Inflammation in NFkB activation is decreased by hypothermia following global cerebral ischemia. Neurobiology of Disease, 2008 (in press)
Tsuruta F, Green, E.M., Roussset, M. Giffard, R.G., Dolmetsch, R.E. PIKfyve/Faab1 regulates Cav1.2 degradation and prevents excitotoxic cell death. Nature Neuroscience, 2008 (in press)
Han RQ, Ouyang YB, Xu L, Agrawal R, Patterson AJ, Giffard RG. Postischemic brain injury is attenuated in mice lacking the β2-Adrenergic Receptor. Anesthesia & Analgesia, 108(1):280-7. 2008.
Giffard R., Han RQ, Emery JF, Duan M, Pittet JF. Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia – the complex roles of Heat Shock Protein 70. Anesthesiology, 109(2):339-48, 2008.
Voloboueva LA, Duan M, Ouyang YB, Emery JF, Stoy C, Giffard RG. Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro. Journal of Cerebral Blood Flow & Metabolism, 28(5):1009-16, 2008.
Voloboueva LA, Suh SW, Swanson RA, Giffard RG. Inhibition of mitochondrial function in astrocytes: implication for neuroprotection, and the influence of neurons. Journal of Neurochemistry, 102:1383-1394, 2007.
Xu L, Wng B, Kaur K, Kho MF, Cooke JP,
Giffard RG. NO(x) and ADMA changes with focal ischemia, amelioration with
the chaperonin GroEL. Neurosci Lett418:
201-204, 2007.
Voloboueva LA,
Suh SW, Swanson RA, Giffard RG. Inhibition of mitochondrial function in
astrocytes: implications for neuroprotection. J Neurochem,
2007 May (in press)
Ouyang YB,
Bolobourva LA, Xu LJ, Giffard RG. Selective dysfunction of hippocampal CA1
astrocytes contributes to delayed neuronal damage after transient forebrain
ischemia. J Neurosci. 27: 4253-4260, 2007.
Lee YS, Ouyang YB,
Giffard RG. Regulation of the rat brain Na+-driven cl-/HCO3- exchanger
involves protein kinase A and a multiprotein signaling complex. FEBS
Letters, 580(20): 4865-4871, 2006.
Ouyang YB, Xu L, Sun YJ,
Giffard RG. Over-expression of inducible heat shock protein 70 and its
mutants in astrocytes is associated with maintenance of mitochondrial
physiology during glucose deprivation stress. Cell Stress & Chaperones, 11(2): 180-186, 2006.
Yenari MA, Xu L, Tang XN,
Qiao Y, Giffard RG. Microglia Potentiate Damage to Blood Brain Barrier Constituents: Improvement by Minocycline In Vivo and In Vitro. Stroke,37(4): 1087-1093, 2006.
Chock VY, Amir G,
Davis CR, Ramamoorthy C, Riemer RK, Ray D, Giffard RG, Reddy VM. Antegrade
cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet
model of cardiopulmonary bypass. Journal of Thoracic and Cardiovascular
Surgery, 131(3): 659-665, 2006.
Xu L ; Dayal M; Ouyang YB ; Sun Yunjuan ; Yang Chin-Fen;
Giffard RG. Chaperonin GroEL and its mutant D87K Protect from Ischemia in vivo and in vitro. Neurobiology of Aging, 27(4):
562-569, 2006.
Sun YJ, Ouyang YB, Chow A-M, Anderson R,
Hecker J, Giffard RG. The carboxyl-terminal domain of inducible HSP70
protects from ischemic injury in vivo and in vitro. . Journal of
Cerebral Blood Flow and Metabolism, 26: 937-950, 2006.
Lee YS, Song YS, Giffard RG, Chan PH.
Biphasic role of nuclear factor –k B on cell survival and COX-2 expression
in SOD1 Tg astrocytes after oxygen glucose deprivation. Journal of
Cerebral Blood Flow and Metabolism, 26(8): 1076-1088, 2006. Epub
December 2005.
Yenari MA., Liu J, Zheng Z, Vexler ZS.,
Lee JE, Giffard RG. Antiapoptotic and Anti-inflammatory Mechanisms of
Heat-Shock Protein Protection. Ann. N.Y. Acad. Sci., 1053: 74-83, 2005.
Giffard RG and Swanson RA.
Ischemia-Induced Programmed Cell Death in Astrocytes. Glia,50:
299-306, 2005.
Wang J, Ma JH, Giffard RG.
Overexpression of copper/zinc superoxide dismutase decreases ischemia-like
astrocyte injury. Free Radical Biology and Medicine,38: 1112-8, 2005.
Chock V and Giffard RG. Development of
Neonatal Murine Microglia In Vitro: Changes in Response to
Lipopolysaccharide and Ischemia-Like Injury. Pediatric Research, 57(4): 475-480, 2005.
Giffard RG and Ouyang Y. Effect of
over-expression of protective genes on mitochondrial function of stressed
astrocytes. Journal of Bioenergetics and Biomembranes, 36:313-315,
2004.
Xu L, Chock V,
Giffard RG. Suceceptability to apoptosis varies with age in cultured
murine neurons and astrocytes: changes in gene expression and
activity. Neurological Research,26: 632-643, 2004.
Giffard RG, Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y,
Sapolsky R, Steinberg G, Hu B, Yenari MA. Chaperones, protein
aggregation, and brain protection from hypoxic/ischemic injury.
Journal of Experimental Biology, 207: 3213-3220, 2004.
Kim JH, Yenari MA, Giffard
RG, Park KA, Lee JE.
Agmatine reduces infarct area in mouse model of transient focal cerebral
ischemia and protects cultured neurons from ischemia-like injury. Experimental
Neurology,189: 122-130, 2004.
Ouyang Y and
Giffard RG. Cellular neuroprotective mechanisms in cerebral
ischemia: Bcl-2 family proteins and protection of mitochondrial
function. Cell Calcium,36: 303-311, 2004.
Wang
J, Bright B, Mochly-Rosen D, Giffard RG. Cell-specific
role for ε- and βI- protein kinase C isozymes in protecting
cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology, 47: 136-145, 2004.
Ouyang Y and
Giffard RG. Changes in astrocyte mitochondrial function with
stress: effects of Bcl-2 family proteins. Neurochemistry
International, 45: 371-379, 2004.
Lee JE, Kim YJ,
Kim JY, Lee WT, Yenari MA, Giffard RG. The 70 kD heat shock protein
suppresses matrix metalloproteinases in astrocytes. Neuroreport,15: 499-502, 2004.
Giffard RG and
Yenari MA. Many mechanisms for Hsp70 protection fro cerebral
ischemia. Journal of Neurosurgical Anestheisa, 16(1):
53-61, 2004.
Giffard RG, Lee YS, Ouyang
YB, Murphy SL, Monyer H. Two variants of the Brain Sodium Driven
Chloride Bicarbonate Exchanger (NCBE): Developmental expression and
addition of a PDZ motif. European Journal of Neuroscience,18: 2935-2945, 2003.
Xu L, Ouyang Y,
Giffard RG. Geldanamycin reduces necrotic and apoptotic injury
due to oxygen-glucose deprivation in astrocytes. Neurological Research, 25:
697-700, 2003.
Qiao Y, Ouyang Y,
and Giffard RG. Overexpression
of HDJ-2 protects astrocytes from ischemia like injury and reduces
redistribution of ubiquitin staining in vitro.
Journal of Cerebral Blood Flow and Metabolism, 23:
1113-1116, 2003.
Yenari MA, Zhao H, Giffard RG, Sobel RA,
Sapolsky RM, Steinberg GK. Gene therapy and hypothermia for stroke
treatment. Annals of the New York Academy of Sciences, 993: 54-68, 2003.
Giffard RG and Fiskum G. Perinatal brain
injury: The role of development in vulnerability. Anesthesiology, 98(5): 1039-1041, 2003.
Ouyang YB and Giffard RG.
Bcl-Xl maintains mitochondrial function in murine astrocytes deprived
of glucose. Journal Cerebral
Blood Flow and Metabolism, 23(3): 275-279, 2003.
Lee WT, Lee SH, Carriedo SG, Giffard RG, Yoon
YJ, Kim JH, Park KA, Lee JE.
UV-vulnerability of human papilloma virus type-16 E7- expressing
astrocytes is associated with mitochondrial membrane depolarization and
caspase-3 activation. Molecules
and Cells, 14(2): 288-294,
2002.
Howard S, Bottino C, Brooke S, Cheng E,
Giffard R, Sapolsky R. Neuroprotective
effects of bcl-2 overexpression in hippocampal cultures:
Interactions with pathways of oxidative damage. Journal of Neurochemistry, 83: 914-923, 2002.
Glassford A, Lee JE, Xu L, Giffard RG. Caspase
inhibitors reduce the apoptotic but not necrotic component of kainate injury
in primary murine cortical neuronal cultures. Neurological
Research , 24: 796-800, 2002.
Giffard
RG and Jaffe RA.
Advances in understanding protection from cerebral ischemia. Current Opinion Anesthesiology. 15: 1-6, 2002.
Ouyang YB, Carriedo SG, Giffard RG.
Effect of BCL-XL over-expression
on reactive oxygen species, intracellular calcium, and mitochondrial
membrane potential following injury in astrocytes. Free Radical Biology and Medicine, 33(4):
544-551, 2002.
Kelly
S, Zhang ZJ, Zhao H, Xu L, Giffard RG, Sapolsky RM, Yenari MA, Steinberg GK. Gene transfer of HSP72 protects cornu ammonis 1 region of the
hippocampus neurons from global ischemia:
Influence of Bcl-2. Annals
of Neurology, 52 (2): 160-166, 2002.
Han HS, Qiao Y, Giffard
RG, Yenari MA. Influence
of mild hypothermia on inducible nitric oxide synthase expression and
reactive nitrogen production in experimental stroke and inflammation. Journal of Neuroscience, 22(10): 3921-3928, 2002.
Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild
hypothermia reduces apoptosis of mouse neurons in vitro early in the
cascade. Journal of Cerebral Blood flow and Metabolism; 22:
21-28, 2002.
Hohen B, Ringer TM, Xu L, Giffard RA,
Sapolsky RM, Steinberg GK, Yenari MA.
Overexpression of HSP72 after the induction of experimental stroke
protects neurons from ischemic damage. Journal of Cerebral Blood Flow and Metabolism; 21:
1303-1309, 2001.
Lee WT, Lee JE, Lee SH, Jang HS, Giffard RG,
Park KA. Human Papilloma Virus
Type 16 E7 Genes Protect Astrocytes Against Apoptotic and Necrotic Death
Induced by Hydrogen Peroxide. Yonsei Medical Journal; 42(5): 471-479, 2001.
Xu L, Sapolsky RM, Giffard RG. Differential
sensitivity of murine astrocytes and neurons from different brain regions to
injury. Experimental Neurology; 169: 416-424, 2001.
Lee J-E, Yenari MA, Sun GH, Xu L, Edmond MR,
Cheng D, Steinberg GK, Giffard RG. Differential neuroprotection from human
heat shock protein 70 overexpression in in vitro and in
vivo models of ischemia and ischemia-like conditions. Experimental Neurology; 170(1): 129-39, 2001.
Papadopoulos MC, Giffard RG, Bell BA.
Principles of gene therapy: Potential applications in the treatment of
cerebral ischaemia. British Journal of Neurosurgery 14(5):
400-407, 2000.
Papadopoulos MC, Giffard RG, Bell B.A. An
introduction to the changes in gene expression that occur after cerebral
ischaemia. British Journal of Neurosurgery 14(4): 305-312,
2000.
Giffard RG, Papadopoulos MC, van Hooft JA, Xu
L, Giuffrida R, Monyer H. The electrogenic sodium bicarbonate cotransporter:
developmental expression in rat brain and possible role in acid
vulnerability. J Neurosci20(3): 1001-8, 2000.
Giffard RG, Morgan RL. Cell death in the
central nervous system: therapeutic possibilities? Reg Anesth Pain Med 25(1): 22-5, 2000.
Xu L, Koumenis IL, Tilly JL, Giffard RG.
Overexpression of bcl-xL protects astrocytes from glucose deprivation and is
associated with higher glutathione, ferritin, and iron levels. Anesthesiology 91(4): 1036-46, 1999.
Yenari MA, Giffard RG, Sapolsky RM, Steinberg
GK. The neuroprotective potential of heat shock protein 70 (HSP70). Mol Med Today 5(12):
525-31, 1999.
Xu L, Lee JE, Giffard RG. Overexpression of
bcl-2, bcl-XL or hsp70 in murine cortical astrocytes reduces injury of
co-cultured neurons. Neurosci Lett 277(3): 193-7, 1999.
Lee
JE, Kim CY, Giaccia AJ, Giffard RG. The E6 and E7 genes of human
pailloma virus-type 16 protect primary astrocyte cultures from
injury. Brain
Research 795: 10-16, 1998.
Papadopoulos,
M. C., Koumenis, I.L., Xu, L., and Giffard, R.G. Potentiation of
murine astrocyte antioxidant defense by bcl-2: protection in part
reflects elevated glutathione levels. European Journal of
Neuroscience 10: 1252-1260, 1998.
Papadopoulos
MC, Koumenis IL, Yuan TY, Giffard RG. Increasing vulnerability of
astrocytes to oxidative injury with age despite constant antioxidant
defenses. Neuroscience 82(3): 915-925, 1998.
Kim
CY, Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG, DiPaolo JA,
Peehl DM, Giaccia AJ. Selection of human cervical epithelial cells
that possess reduced apoptotic potential to low oxygen conditions. Cancer Research 57(19):
4200-4204, 1997.
Newcomb
R, Sun X-Y, Taylor L, Curthoys N, Giffard RG. Increased production
of extracellular glutamate by the mitochondrial glutaminase
following neuronal death. Journal of Biological
Chemistry 272 (17): 11276-82, 1997.
Papadopoulos MC,
Koumenis IL, Dugan LL, Giffard RG. Vulnerability to glucose
deprivation injury correlates with glutathione levels in astrocytes. Brain Research 748:
151-156, 1997.
Bergeron
M, Mivechi NF, Giaccia AJ, Giffard RG. Mechanism of heat shock
protein 72 induction in primary cultured astrocytes after
oxygen-glucose deprivation. Neurological Research 18:
64-72, 1996.
Papadopoulos
MC, Sun X, Cao J, Mivechi N, Giffard RG. Overexpression of HSP-70
protects astrocytes from combined oxygen-glucose deprivation. Neuroreport 7(2): 429-432, 1996.
Regan
RF, Witz A, Panter SS, Tilly JL, Giffard RG. Ultrastructure of
excitotoxic neuronal death in murine cortical culture. Brain Research 705(1-2): 188-198, 1995.
Bruno
VMG, Battaglia G, Copani A, Giffard RG, Raciti G, Raffaele R,
Shinozaki H, Nicoletti F. Activation of class II or III metabotropic
glutamate receptors protects cultured cortical neurons against
excitotoxic degeneration. European Journal
of Neuroscience 7: 1906-1913, 1995.
Maier CM, Sun
GH, Kunis DM, Giffard RG, Steinberg GK. Neuroprotection by the
N-methyl-D-aspartate Receptor Antagonist CGP 40116: In Vivo and in Vitro Studies. Journal of
Neurochemistry 65: 652-659, 1995.
Pérez-Pinzón MA, Maier
CM, Yoon EJ, Sun GH, Giffard RG, Steinberg GK. Correlation of
CGS19755 Neuroprotection Against in vitro Exitotoxicity and
Focal Cerebral Ischemia. Journal of Cerebral Flow and Metabolism 15:
865-876, 1995.
Dugan LL,
Bruno VMG, Amagasu SM, Giffard RG. Glia modulate the response of
murine cortical neurons to excitotoxicity: Glia exacerbate AMPA
neurotoxicity. Journal of Neuroscience 15: 4545-4555,
1995.
Bruno
VMG, Goldberg MP, Dugan LL, Giffard RG, Choi DW. Neuroprotective
Effect of Hypothermia in Cortical Cultures Exposed to Oxygen-Glucose
Deprivation or Excitatory Amino Acid. Journal of Neurochemistry 63:
1398-1406, 1994.
Kaku
DA, Giffard RG, Choi DW. Neuroprotective Effects of Glutamate
Antagonists and Extracellular Acidity. Science 260: 1516-1518, 1993.
Giffard
RG, Weiss JH, Swanson RA, Choi DW. Secobarbital Attenuates
Excitotoxicity but Potentiates Oxygen-Glucose Deprivation Neuronal
Injury in Cortical Cell Culture. Journal of Cerebral Blood Flow and Metabolism 13: 803-810, 1993.
Monyer
H, Giffard RG, Hartley DM, Dugan LL, Goldberg MP, and Choi DW.
Oxygen or glucose deprivation-induced neuronal injury in cortical
cell cultures is reduced by tetanus toxin. Neuron 8:
967-973, 1992.
Giffard
RG, Monyer H, and Choi, DW. Selective vulnerability of cultured
cortical glia to injury by extracellular acidosis. Brain
Research 530: 138-141, 1990.
Giffard RG, Monyer H, Christine CW, and Choi,
DW. Acidosis reduces NMDA receptor activation, glutamate neurotoxici-ty and
oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Research 506: 339-342, 1990.
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