Mechanisms of DNA double-stranded break repair and Chromosomal Translocation

The Frock Lab studies the genome-wide fate of various forms of double-stranded DNA breaks (DSBs). Projects in the lab use a combination of genetics, molecular biology, next generation sequencing, and bioinformatics to uncover DSB mechanisms and to reveal a deeper understanding of DSB repair processes.

The long term goal of the Frock lab is to develop novel cancer diagnostics/therapeutics and genome editing approaches.

Please visit frocklab.com for more information.


Latest News in the Frock Lab

Welcome to Carrie Truong working on a remote project from St. Joseph Notre Dame! -- November 2023

Congratulations to Jinglong for his published paper on Cas9 cleavage plasticity in the Nature Structural & Molecular Biology! -- October 2023

Welcome, Elvis Lang, to the lab this summer coming from from Case Western Reserve! -- June 2023

Check out the first episode of Science in 5 by Kai Zheng on youtube! -- June 2023

Welcome to Darsh Vithlani working on a remote summer project with us from the Institute of Chemical Technology in Mumbai, India! -- May 2023

Congratulations to Richard Frock who received a Research Scholar Grant from the American Cancer Society (ACS) -- April 2023

Check out Paul’s manuscript on FLASH radiotherapy, hypoxia, apoptosis, and chromosome translocations! -- March 2023

Excellent presentation by Jinglong for his Stanford Cancer Institute talk! -- February 2023

Science in 5 or Sci-5 collaboration with Kai Zheng is in the works…stay tuned! -- January 2023

Great work by Jinglong and colleagues for putting together an excellent manuscript! -- November 2022

Welcome, Anushka Edlabadkar, to the Frock lab!  The third time’s a charm! -- July 2022

Welcome, Long Le and Kristin Conner, to the Frock lab! -- June 2022

Congrats to Jinglong for getting accepted into the GSB Ignite program! -- May 2022

Great job, Jinglong, on your SCI seminar presentation! -- March 2022

Congratulations to Cheyenne for getting accepted in to the BIO-X summer program! Great way to start off the meiosis collaboration. -- February 2022

Congrats to current and alum lab members for helping with the DNA end joining review now published in Biomolecules. -- October 2021

Welcome to Anita Taft, Cheyenne Ali Sadeghi and Jodie Meng, Undergraduate Interns to the Frock Lab -- July 2021

Our part in a great collaborative genome therapy study for Sickle Cell Disease led by the Porteus group is now out in Science Translational Medicine. -- June 2021

Our JoinT-seq paper was highlighted with a Q & A as a publication of the week by Stem Cell Technologies! -- June 2021

Congratulations to Paul for nabbing a position at Nucleix!  We can’t wait to see what comes next. -- June 2021

Just in Time!  Our manuscript describing JoinT-seq was published in the Proceedings of the National Academy of Sciences.  Congrats to Marie and Josefin for developing such a useful tool. -- May 2021

A proud farewell to Marie!  An integral lab member, we wish her all the best in Europe. -- May 2021

Great talk by Jinglong for the Stanford Cancer Institute Radiation Biology Seminar! -- April 2021

Brilliant team effort! Our long-awaited DSB repair study in G0/G1-phase is out on bioRxiv. -- February 2021

The long and the short of it - farewell to Josefin and Carlos. Exciting opportunities lie ahead for you both! -- February 2021

Well done, Marie! Collaborative paper led by the Gonçalves group is published in Nucleic Acids Research. -- January 2021

Frock Lab virtual reunion! -- September 2020

Welcome Carlos Origel, Postdoctoral Scholar to the Frock Lab -- March 2020

Welcome Jinglong Wang, Postdoctoral Scholar to the Frock Lab -- January 2020

Congratulations to Dr. Frock for becoming a V Scholar from the V Foundation for Cancer Research! -- November 2019

Way to go, Paul, for presenting at the Department Retreat at SLAC and then giving a different talk for the Division Floor Meeting the following week! -- October 2019

Welcome Marie Le Bouteiller, Postdoctoral Scholar to the Frock Lab -- September 2019

Finn’s summer internship is over but we hope to see him again in the near future! We can’t wait to see what he’ll do next! -- August 2019

Welcome Paul Barghouth, Postdoctoral Scholar to the Frock Lab -- June 2019

Grateful for the support in the lab’s first phase, Melissa Wong! Excited to have Meg Fuentes support the next phase of the lab. -- June 2019

Welcome Finn Maniscalco, Summer Intern to the Frock Lab -- June 2019 to August 2019

Micah gave an excellent Floor Meeting presentation! -- May 2019

Congratulations to Dr. Frock for receiving the Career Development Award from the Radiation Research Foundation! -- April 2019

Josefin gave an awesome presentation for the Division Floor Meeting! -- February 2019

Woot! Collaborative paper led by the Weinstock group is published in the Proceedings of the National Academy of Sciences. -- August 2018

Welcome, Josefin Kenrick, to the Frock lab! -- July 2018

Welcome, Micah Kelly, to the Frock lab! -- March 2018

Dr. Frock was mentioned in The Scientist: New Methods to Detect CRISPR Off-Target Mutations! -- March 2018

Dr. Frock was mentioned in a Biotechniques article: CRISPR/Cas9 eliminates chromosomes. -- January 2018