Research in the Feldman Lab

The aim of our laboratory is to elucidate the role of the endocrine system in both health and the development of diseases.  Through this work, we hope to increase our understanding of the important physiological processes that are controlled by hormones and how alterations in hormone levels perturb the body’s homeostasis and cause disease in people.  Our goal is to apply discoveries we make in the laboratory toward the development of novel therapeutics for a variety of diseases.

A current major focus of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions. We use molecular biology, biochemistry, tissue culture assays and mouse models to elucidate the relevant pathways regulated by hormones in cell fate decisions. Our primary objective is to understand the relationship between the endocrine influence on stem cell fate and physiology and pathophysiology found in humans.

Currently, most stem cell therapies under development require the isolation of stem cells from a patient or donor followed by manipulation in culture, outside of the body and finally transplantation into the patient.  The goal of our research is to develop novel tools that will allow us to regulate stem cells and stem cell fate decisions within a living person. We envision that a variety of clinical conditions ranging from diabetes to cancer could be improved or cured through this approach.  In addition, we hope to apply these tools to regenerative medicine where they could be used to help treat debilitating diseases such as the muscular dystrophies and sarcopenia.