Animal Research

(1)  Systemic hypoxia led to little neuronal loss and dramatic optic nerve glial response. Experimental eye research. Mesentier-Louro, L. A., Shariati, M. A., Dalal R., Camargo, A., Kumar, V., Shamskhou, E. A., de Jesus Peres, V., Liao, Y. J. 2020: 107957.

Description of the effects of 48h systemic hypoxia in the retina and optic nerve. It was found that hypoxia led to astrocyte endoplasmic reticulum (ER) stress in the retina and anterior optic nerve, as well as oligodendrocyte loss at myelinated optic nerve, which was reverted by 4-phenylbutiric acid, a compound that is typically associated to ER stress reduction.

(2)  Dual specific phosphatase 14 deletion rescues retinal ganglion cells and optic nerve axons after experimental anterior ischemic optic neuropathy. Current Eye Research. Kumar, V., Shariati, M. A Mesentier-Louro, L. A., Oh, A., Russano, K., Goldberg, J. L., Liao, Y. J. 2020; 1-9.

Genetic deletion of Dusp14, a MAPK phosphatase important in KFL9-mediated inhibition of RGC survival, led to increased activation of MAPK ERK1/2 and greater RGC and axonal survival after experimental AION. Inhibiting Dusp14 or activating the MAPK pathway should be examined further as a potential therapeutic approach to treatment of AION.

(3)  Anatomic, genetic and functional properties of the retinal circulation in pulmonary hypertension. Pulmonary circulation. Nickel, N. P., Shamskhou, E. A., Razeen, M. A., Condon, D. F., Messentier-Louro, L. A., Dubra, A., Liao, Y. J., Zamanian, R. T., Yuan, K., Perez, V. A. J. 2020; 10(2) 1- 4.

There is evidence that the retina circulation could be affected in Pulmonary arterial hypertension (PAH) which suggests the existence of a lung-eye axis. These findings have potential far-reaching implications to the pathobiology and clinical evolution of PAH since there are no easily accessible imaging tools available to functionally or anatomically assess the pulmonary microcirculation or stage the degree of vascular remodeling in patients.

(4)  Increased ER stress after experimental ischemic optic neuropathy and improved RGC and Oligodendrocytes survival after treatment with chemical chaperon. Investigative ophalmology & visual science. Kumar, V., Mesentier-Louro, L. A., Oh, A. J., Heng, K., Shariati, M. A., Huang, H., Hu, Y., Liao, Y. J.2019; 60(6): 1953-66.

In acute AION there is an increased ER stress and differential expression of ER stress markers CHOP and GRP78 in the retina and optic nerve. Rescue of RGCs and oligodendrocytes with 4-PBA provides support for ER stress reduction as possible treatment for AION.

(5)  Direct targeting of the mouse optic nerve for therapeutic delivery. Journal of neuroscience methods. Mesentier-Louro, L. A, Dodd, R., Domizi, P., Nobuta, H. Wernig, G., Liao, Y. J. 2019; 313:1-5.

Description of 3 surgical methods to deliver compounds into the mouse optic nerve: intra-orbital, intra-optical foramen and intracranial.