Patients at high risk of relapse and/or development of subsequent malignancies due to solid organ transplantation or other reasons (history of chronic lymphocytic leukemia, lymphoma, immunosuppressive medication, history of radiation therapy, genetic predisposition to skin cancer, etc.) are followed closely in the Stanford High Risk Non-melanoma Skin Cancer Clinic where frequent skin examination, early intervention and prevention, and advanced treatments such as chemowraps, cyclical photodynamic therapy, systemic chemoprevention, and other novel therapies are employed. Locally advanced squamous cell carcinoma may be co-managed through the High Risk Tumor Board. Patients with metastatic squamous cell carcinoma may be seen in a multispecialty fashion with dermatology, medical oncology, radiation oncology, and other providers as deemed necessary. We also now see patients with Merkel Cell Carcinoma, a rare, aggressive non-melanoma skin cancer.