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Welcome to the de la Zerda Group in the Departments of Structural Biology and Electrical Engineering (courtesy) at Stanford University. We aim to build imaging instrumentation and chemical tools that can visualize the complex behavior of biomolecules in living subjects. The expression patterns of many biomolecules (e.g., signaling factors and posttranslational modifications) changes in time, space and local environments. Understanding these changes in the context of living tissues may give rise to new diagnostic and therapeutic approaches, and can further reveal new molecular mechanisms not otherwise visible in traditional biochemical studies. We build optical imaging instrumentation to visualize these complex behaviors in cancer and ophthalmic disease animal models. Our research efforts span both basic science and clinically translatable work.