Medical School Office Building (MSOB)
|DATE:||November 2, 2017|
|TIME:||1:30 - 2:50 pm|
|TITLE:||Naive statistical tests in the quest for the meaning of life, the universe and everything|
Computer Science, Developmental Biology & Pediatrics (Medical Genetics), Stanford
I will present a smorgasbord of statistical tests we devise in different genomic contexts. Some on text, some on DAGs, all revolve around our genome. After presenting each scenario I will pause to wonder out loud whether better tests cannot be designed, and will look to the audience for advice.
CY McLean, D Bristor, M Hiller, G Bejerano et al. GREAT improves funcational interpretation of cis-regulatory regions. NATURE BIOTECHNOLOGY 28, 485-501 (2010).
A Marcovitz, Y Turakhia, M Gloudemans, G Bejerano et al. A novel unbiased test for molecular convergent evolution and discoveries in echolocating, aquatic and high-altitude mammals. bioRXiv doi: https://doi.org/10.1101/170985
J Birgmeier, M Haeussler, CA Deisseroth, G Bejerano et al. AMELIE accelerates Mendelian patient diagnosis directly from the primary literature. bioRXiv doi: https://doi.org/10.1101/171322
KA Jagadeesh, AM Wenger, MJ Berger, G Bejerano et al. M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity. Nature Genetics 48, 1581–1586 (2016) | doi:10.1038/ng.3703