Workshop in Biostatistics

DATE: May 5, 2016
TIME: 1:30 - 3:00 pm
LOCATION: Medical School Office Building, Rm x303
TITLE: A View to Precision Medicine: Findings from the Research Program on Genes, Environment, and Health
SPEAKER:

Eric Jorgenson
Research Scientist
Division of Research, Kaiser Permenente Northern California

Abstract:

In his state of the union speech in 2015, President Obama announced the launch of “a New Precision Medicine Initiative.” A central pillar of this initiative is the development of a research cohort that will enroll more than one million participants.  Why build a one million person cohort?  The stated hope is that this new cohort will help advance our understanding of the causes of disease and variation in drug response, with a long term goal of making people healthier.  In this presentation, I will focus on a question that is one order of magnitude smaller: what can we do with a one hundred thousand person cohort?  I will discuss findings from the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort, a study of 110,266 members of the Kaiser Permanente Northern California Health Plan.

Suggested Reading:

Microarray Coverage and Sample Size in Genetic Association Studies:

  1. Jorgenson E, Witte JS.  Coverage and power in genomewide association studies.  Am J Hum Genet. 2006; 78(5):884-8.
    http://www.ncbi.nlm.nih.gov/pubmed/16642443
  2. Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS. The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies. Genet Epidemiol. 2013 May; 37(4):383-92.
    http://www.ncbi.nlm.nih.gov/pubmed/23529720

Development of the GERA Cohort Genomic Data:

  1. Kvale MN, Hesselson S, Hoffmann TJ, et al.  Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1051-60.
    http://www.ncbi.nlm.nih.gov/pubmed/26092718
  2. Banda Y, Kvale MN, Hoffmann TJ, et al.  Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1285-95.
    http://www.ncbi.nlm.nih.gov/pubmed/26092716

A Genome-wide Association Study of Hernia Susceptibility:

Jorgenson E, Makki N, Shen L, et al. A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. Nat Commun. 2015 Dec 21;6:10130.
http://www.ncbi.nlm.nih.gov/pubmed/26686553