CVI Manuscript Awards

Each Winter, the Cardiovascular Institute awards authors of outstanding manuscripts published in the previous year.   

2018

Jingjing Li, PhD

Decoding the Genomics of Abdominal Aortic Aneurysm  

Li J, Pan C, Zhang S, Spin JM, Deng A, Leung LLK, Dalman RL, Tsao PS, Snyder M

Labs of Michael Snyder, PhD and Phil Tsao, PhD

Ning Ma, PhD

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells  

Ma N, Zhang JZ, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC

Lab of Joseph C. Wu, MD, PhD

Takeshi Nishi, MD

Fractional Flow Reserve and Quality-of-Life Improvement After Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease

Nishi T, Piroth Z, De Bruyne B, Jagic N, Möbius-Winkler S, Kobayashi Y, Derimay F, Fournier S, Barbato E, Tonino P, Jüni P, Pijls NHJ, Fearon WF

Labs of William F. Fearon and Peter J. Fitzgerald

David Paik, PhD

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells  

Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC.

Lab of Joseph C. Wu, MD, PhD

Darshan Trivedi, PhD

Deciphering the Super Relaxed State of Human β-cardiac Myosin and the Mode of Action of Mavacamten from Myosin Molecules to Muscle Fibers

Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, Spudich JA.

Lab of James Spudich, PhD

Ke Yuan, PhD

Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension      

Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA.

Lab of Vinicio de Jesus Perez, MD

2017

Myriam Amsallem, MD

Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models

Amsallem M, Sweatt AJ, Aymami MC, Kuznetsova T, Selej M, Lu H, Mercier O, Fadel E, Schnittger I, McConnell MV, Rabinovitch M, Zamanian RT, Haddad F.Circ Cardiovasc Imaging.  2017 Jun;10(6).

Labs: Francois Haddad, MD; Roham Zamanian, MD

Yuhei Kobayashi, MD

Agreement of the Resting Distal to Aortic Coronary Pressure With the Instantaneous Wave-Free Ratio

Kobayashi Y, Johnson NP, Zimmermann FM, Witt N, Berry C, Jeremias A, Koo BK, Esposito G, Rioufol G, Park SJ, Nishi T, Choi DH, Oldroyd KG, Barbato E, Pijls NHJ, De Bruyne B, Fearon WF; CONTRAST Study Investigators. J Am Coll Cardiol. 2017 Oct 24;70(17):2105-2113.

Lab: William Fearon, MD

Qing Liu, PhD

Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs

Liu Q, Jiang C, Xu J, Zhao MT, Van Bortle K, Cheng X, Wang G, Chang HY, Wu JC, Snyder MP. Circ Res. 2017 Aug 4;121(4):376-391.

Lab: Michael Snyder, PhD

Mingtao Zhao, PhD

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs

Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC.Proc Natl Acad Sci USA. 2017 Dec 26;114(52):E11111-E11120.

Lab: Joseph Wu, MD, PhD

2016

Mingxia Gu, PhD

Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M. Cell Stem Cell. 2016 Dec 2.

Kozo Okada, MD

Attenuated-Signal Plaque Progression Predicts Long-Term Mortality After Heart Transplantation: IVUS Assessment of Cardiac Allograft Vasculopathy.

Okada K, Fearon WF, Luikart H, Kitahara H, Otagiri K, Tanaka S, Kimura T, Yock PG, Fitzgerald PJ, Yeung AC, Valantine HA, Khush KK, Honda Y. J Am Coll Cardiol. 2016 Jul 26;68(4):382-92.

Fatima Rodriguez, MD, MPH

Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease.

Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA. JAMA Cardiol. 2017 Jan 1;2(1):47-54.

 

Elena Matsa, PhD

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.

Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Cell Stem Cell. 2016 Sep 1;19(3):311-25.

2015

Alexandre Ribeiro, PhD

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Alexandre J. S. Ribeiro, Yen-Sin Ang, Ji-Dong Fu, Renee N. Rivas, Tamer M. A. Mohamed, Gadryn C. Higgs, Deepak Srivastava, and Beth L. Pruitt. Proc Natl Acad Sci U S A. 2015 112(41)

Ke Wei, PhD

Epicardial FSTL1 reconstitution Regenerates the Adult Mammalian Heart

Ke Wei, Vahid Serpooshan, Cecilia Hurtado, Marta Diez-Cunado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura4, Xueying Tian, Qiaozhen Liu, AndrewWang,Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano. Nature 525, 479–485

Haodi Wu, PhD

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

Haodi Wu, Jaecheol Lee, Ludovic G. Vincent, Qingtong Wang, Mingxia Gu, Feng Lan, Jared M. Churko, Karim I. Sallam, Elena Matsa, Arun Sharma, Joseph D. Gold, Adam J. Engler, Yang K. Xiang, Donald M. Bers, and Joseph C. Wu. Cell Stem Cell: 17, 89–100

Yuhei Kobayashi, MD

The Prognostic Value of Residual Coronary Stenoses After Functionally Complete Revascularization

Yuhei Kobayashi, Chang-Wook Nam, Pim A.L. Tonino, Takumi Kimura, Bernard De Bruyne, Nico H.J. Pijls, William F. Fearon, on behalf of the FAME Study Investigators. J Am Coll Cardiol. 2016;67(14)

2014