Publications

Featured Articles

Between Region genetic diversity reflects the mode and tempo of tumor evolution

A quantitative framework to infer signals of selection from cancer genomes.


A Big Bang Model of human colorectal tumor growth

After initiation, a tumor grows predominantly as a single expansion populated by numerous heterogeneous subclones...


2019

Rueda OM, Sammut SJ, Seoane JA, Chin SF, Caswell-Jin J, Ali R, Pereira B, Batra R, Bruna A, Callari M, Provenzano E, Liu B, Wright K, Parisien P, Gillett C, McKinney S, Green AR, Murphy L, Purushotham A, Ellis IO, Pharoah PD, Rueda R, Aparicio S, Caldas C & Curtis C. The dynamics of breast cancer relapse reveal late-recurring ER+ genomic subgroups. Nature, 2019doi: 10.1038/s41586-019-1007-8.

Caswell-Jin JL, McNamara K, Reiter JG, Sun R, Hu Z, Ma Z, Ding J, Suarez CJ, Tilk S, Raghavendra A, Forte V, Chin SF, Bardwell H, Provenzano E, Caldas C, Lang J, West R, Tripathy D, Press MF, Curtis C. Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapyNature Communications 10(1):657, 2019.

2018

Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C; Cancer Genome Atlas Analysis Network, Greenleaf W & Chang HJScience 362(6413) 2018.

Press MF, Seoane JA, Curtis C, Guzman R, Quinaux E, Sauter G, Eiermann W, Mackey JR, Robert N, Pienkowski T, Crown J, Martin M, Valero V, Bee V, Ma Y, Villalobos I, & Slamon DJ. Assessment of HER2 / ERBB2 Status in “HER2 Equivocal” Breast Cancers and the ASCO-CAP Guidelines:  False-Positives due to Heterozygous Deletions of Alternative Control LociJAMA Oncology JAMA Oncoldoi: 10.1001/jamaoncol.2018.6012 2018.

Probert C, Curtis C. A role for chromatin regulatory dynamics in breast cancer evolution. Nature Medicine, News & Views. 24(9):1309-1311, 2018.

Bhatt AS, Curtis C. AGBT meeting reportGenome Biol. 2018 May 21;19(1):60. doi: 10.1186/s13059-018-1447-8.

Pogrebniak K & Curtis C. Harnessing tumor evolution to circumvent resistance. Trends In Genetics, in press.

Calvin Kuo & Curtis C. Organoids reveal cancer dynamics. Nature, News & Views. 556(7702):441-442, 2018.

Afghahi A, Purington N, Han S, Desai M, Pierson E, Mathur M, Seto T, Thompson C, Rigdon J, Telli M, Badve S, Curtis C, West R, Horst K, Gomez G, Ford J, Sledge G & Kurian A. Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer. Clinical Cancer Research, pii: clincanres.1323.2017. doi: 10.1158/1078-0432.CCR-17-1323, 2018.

Rogers ZN, McFarland CD, Winters IP, Seoane JA, Brady JJ, Curtis C, Petrov D & Winslow MM. The fitness landscape of tumor suppression in lung adenocarcinoma in vivo. Nature Genetics 2018 doi:10.1038/s41588-018-0083-2.

Williams MK, Werner B, Curtis C, Barnes CP, Sottoriva S & Graham TA. Quantification of subclonal selection in cancer from bulk sequencing dataNature Genetics, 50(6);895-903 2018.

Cho S, Xu J, Sun R, Mumbach M, Carter AC, Chen YG, Yost KE, Kim J, Nevins S, Chin SF, Carlos Caldas C, Liu JS, Horbeck M, Lim DA, Weissman JS, Curtis C & Chang HY. Promoter of lncRNA gene PVT1 is a tumor suppressor DNA boundary elementCell, 31;173(6):1398-1412.e22, 2018.

2017

Mello SS, Valente LJ, Raj N, Seoane JA, ... , Curtis C, Attardi LD. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic CancerCancer Cell. 32(4):460-473.e6 2017.

Sun R, Hu Z, Curtis, C. Big Bang tumor dynamics and clonal evolution. In Cancer Evolution. Cold Spring Harbor Perspect Med, Cold Spring Harbor Press. pii: a028381 2017. doi: 10.1101, 2017.

Yan KS, Gevaert O, Zheng GX, Anchang B, Probert CS, ... , Curtis C, Ji HP, Li L, Henning SK, Wong MH & Kuo CJ. Mature enteroendocrine cells possess injury-inducible reserve stem cell function. Cell Stem Cell, 6;21(1):78-90.e6, 2017.

Sun R, Hu Z, Sottoriva A, Graham TA, Harpak A, Ma Z, Shibata D & Curtis C. Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nature Genetics, 2017 doi: 10.1038/ng.3891.

Hu Z, Sun R & Curtis, C. A Population Genetic Perspective on Tumor Evolution. Evolutionary principles – heterogeneity in cancerBiochimica et Biophysica Acta - Reviews on Cancer, pii: S0304-419X(17)30046-X. doi: 10.1016/j.bbcan.2017.03.001, 2017.

Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K & Marjoram P. Early mutation bursts and cancer stem cell division asymmetry in colorectal tumors. PLoS One, 12(3):e0172516, 2017.

TCGA Research Atlas Network, Seoane JA…Curtis, C...  Integrated genomic characterization of oesophageal carcinoma. Nature Jan, 2017 doi: 10.1038/nature20805.

Gendelman R, Xing H, Mirzoeva OK, Sarde P, Curtis C, Feiler HS, McDonagh P, Gray JW, Khalil I, & Korn MW.. Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell cycle progression and survival in cancer cells. Cancer Research, 2017.

2016

Hu Z, Curtis C. Inferring tumor phylogenies from multi-region sequencing. Cell Syst. 3(1):12-4, 2016. 

Hu Z, Mao JH, Curtis C, Huang G, Kuo WL, Lenburg ME, Gu S, Korkola JE, Ziyad S, Bayani N, Samarajiwa S, Seoane JA, Dan M, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, & Gray JW. Genomic co-amplification up-regulates a mitotic gene network whose activity predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Research, 18(1):70, 2016. 

2015

Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathology, 2015.    

Sottoriva A, Kang H, Ma Z, Graham TA, Salomon M, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D & Curtis C. A Big Bang Model of human colorectal tumor growthNature Genetics, 2015.

** Recommended by Faculty of 1000 Prime

Nature Genetics News and Views Commentary: Big Bang and Context Driven Collapse

Nature Reviews Cancer Research Highlight: Explosive Beginnings

Curtis C. Genomic Profiling of breast cancersCurr Opin Obstet Gynecol, 27(1), 2015.

Piccirillo SGM, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, Heywood R, Francis NJ, Collins VP, Venkitaraman AR, Curtis C, Marioni JC, Tavaré S & Watts C. Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zoneCancer Res 75(1), 2015. 

Moen Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah SP, Lingjaerde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, METABRIC Group, Tavaré S, Brenton JD, Pharoah PD, Børrensen-Dale AL, Aparicio S & Caldas C. A tumor DNA complex-arm aberration index is an independent predictor of survival in breast and ovarian cancerMolecular Oncology9(1), 2015. 

2014

Ali HR, Rueda OM, Chin SF, Curtis C, Dunning M, Aparicio S and Caldas C. Genome-driven integrated classification of breast cancer validated in over 7,500 samplesGenome Biology 15(8), 2014. 

2013

2012

    Yuan, Y, Failmezger H, Rueda OM, Ali R, Gräf S, Schwarz R, Chin SF, Curtis C, Bardwell H, Provenzano E, Aparicio S, Caldas C & Markowetz F. Quantitative image analysis of cellular heterogeneity in breast tumorsScience Translational Medicine, 4(157):157ra143, 2012. 

    Lynch AG, Chin SF, Dunning MJ, Caldas C, Tavaré S & Curtis C. Calling sample mixups in cancer population studiesPLoS One, 7(8): e41815, 2012. 

    Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Børrensen-Dale, Brenton JD, Tavaré, Caldas C & Aparicio S. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature, 486(7403):346-52, 2012. 

    Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T,Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancersNature, 486(7403):395-9, 2012. 

    Maia AT, Antoniou AC, O'Reilly M, Samarajiwa S, Dunning M, Kartsonaki C, Chin SF, Curtis C, McGuffog L, Domchek SM, Embrace E, Easton DF, Peock S, Frost D, Evans DG, Eeles R, Izatt L, Adlard J, Eccles D, Gemo G, Sinilnikova OM, Mazoyer S, Stoppa-Lyonnet D, Gauthier-Villars M, Faivre L, Venat-Bouvet L, Delnatte C, Nevanlinna H, Couch FJ, Godwin AK, Caligo MA, Swe-Brca SB, Barkardottir RB, Kconfab K, Chen X, Beesley J, Healey S, Caldas C, Chenevix-Trench G, Ponder BA. Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriersBreast Cancer Res, 18;14(2):R63, 2012. 

2011 & Earlier