Comparative Medicine


The laboratory mouse is the most widely used mammalian model for biomedical research and comprises over 90% of the non-aquatic, laboratory animals at Stanford.  As Director of the Rodent Health Surveillance Program and the Director of Rodent Services, my research and clinical expertise is in mouse reproductive biology, mouse models of mammalian sex determination and sexual differentiation, and mouse models of infectious diseases.  Past research focused on the molecular genetics underpinning a mouse model of XY sex reversal and the effect of the bacterial pathogen Helicobacter hepaticus on chemical and genetic models of colon cancer.  Current collaborative research is the development of a mouse model for dengue virus to study the relationship between autophagy and dengue virus virulence.



Gonads from a hermaphroditic mouse


Claude Nagamine, DVM, PhD

Assistant Professor
(650) 498-4773
(650) 725-0940 (fax)

GI tract of mouse

(A) Whole mount of the gastrointestinal tract of a mouse. Asterisks identify dilatations in the small intestine identifying the location of mucosal tumors. st, stomach; si, small intestine; ce, cecum; co, colon. (B) Mucosal surface of one of the dilatations in panel A, showing the presence of large, sessile adenomas (arrows). (C, D) Immunostaining for Β-catenin showing high expression in the adenomas. (Scale bar = 250 Μm) (Nagamine et al. Infect Immun. 2008. 76:2758-2766).

gonads of mouse

Histology of a gonad with both testicular (left) and ovarian (right) tissues



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