Research
Research: The Comparative Approach
The concept of “One medicine, one health” is based upon a fundamental idea: advances in both human and veterinary medicine are dependent on overlapping technologies and research discoveries. This is the essence of comparative medicine—the study of the close connections between human and animal health and disease.
The faculty in the Department of Comparative Medicine at Stanford are basic researchers and veterinary clinician scientists, all working toward one health. For example, our faculty study animal models of epilepsy, neuronal reorganization and recovery after injury, and cortical neuronal circuitry to study physiological and patho-physiological processes. The veterinary clinical faculty in the department also have research interests that focus on topics pertaining to laboratory animal and wildlife health and animal models of human and animal diseases.
Recent faculty publications typical of the comparative approach
Animal Model: Mouse
SETD3 is an Actin Histidine Methyltransferase that Prevents Primary Dystocia
Wilkinson A, Diep J, Ooi Y, Li T, Dai S, Zhang X, Vilches-Moure J, Casey KM, Mak J, Cowan T, Elias J, Cheng X, Nagamine C, Carette J, Liu S, Song D, Horton J, Liu C, Trivedi D, Ruppel K, Spudich J, Gozani O. SETD3 is an Actin Histidine Methyltransferase that Prevents Primary Dystocia. Nature 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10. PMID: 30626964 PMCID: PMC6511263
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. (2022) The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. PMID: 36074821 PMCID: PMC9547973 DOI: 10.1126/science.abn5648
Azetidine-2-carboxylic acid-induced oligodendrogliopathy: relevance to the pathogenesis of multiple sclerosis.
Sobel RA, Albertelli M, Hinojoza JR, Eaton MJ, Grimes KV, Rubenstein E. Azetidine-2-carboxylic acid-induced oligodendrogliopathy: relevance to the pathogenesis of multiple sclerosis. Journal of Neuropathology and Experimental Neurology. 2022, May 20;81(6):414-433. doi: 10.1093/jnen/nlac028. PMID: 35521963 PMCID: PMC9123080
Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Adamska JZ, Verma R, Gupta S, Hagan T, Wimmers F, Floyd K, Li Q, Valore EV, Wang Y, Trisal M, Vilches-Moure JG, Subramaniam S, Walkley CR, Suthar MS, Li JB, Pulendran B, “Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens immunity against SARS-CoV-2.” Cell Reports. 2023 Jan 31. 42(1): 112038. DOI: 10.1016/j.celrep.2023.112038. PMCID: PMC9842623 NIHMSID: NIHMS1870550 PMID: 36732946
Animal Model: Rat
Ventral hippocampal formation is the primary epileptogenic zone in a rat model of temporal lobe epilepsy
Buckmaster PS, Reyes B, Kahn T, Wyeth M (2022) Ventral hippocampal formation is the primary epileptogenic zone in a rat model of temporal lobe epilepsy. Journal of Neuroscience. 42:7482-7495. doi: 10.1523/JNEUROSCI.0429-22.2022. PMID: 35995562 PMCID: PMC9525166
Focused ultrasound-induced inhibition of peripheral nerve fibers in an animal model of acute pain.
Anderson TA, Pacharinsak C, Vilches-Moure JG, Zuchero JB, Butts-Pauly K, Yeomans D, “Focused ultrasound induced inhibition of peripheral nerve fibers in an animal model of acute pain.” Regional Anesthesia & Pain Medicine. 2023 Sep;48(9):462-470. doi: 10.1136/rapm-2022-104060. Epub 2023 Feb 23. PMID: 36822815.
Animal Model: Nonhuman Primate
Behavioral recovery after a spinal deafferentation injury in monkeys does not correlate with extent of corticospinal sprouting
Crowley, M., Lilak, A., Garner, J.P. & Darian-Smith, C. (2022). "Behavioral recovery after a spinal deafferentation injury in monkeys does not correlate with extent of corticospinal sprouting." Behavioral Brain Research. 2022 Jan 7:416:113533. doi: 10.1016/j.bbr.2021.113533. Epub 2021 Aug 25. PMID: 34453971 PMCID: PMC8492525
Animal Model: Sea Lion
Cannabinoid receptor 1-labeled boutons in the sclerotic dentate gyrus of epileptic sea lions
Seelman A, Vu K, Buckmaster P, Field C, Johnson S, Mackie K, Wyeth M (2022) Cannabinoid receptor 1-labeled boutons in the sclerotic dentate gyrus of epileptic sea lions. Epilepsy Research 2022 Aug:184:106965. doi: 10.1016/j.eplepsyres.2022.106965. Epub 2022 Jun 16. PMID: 35724601
