Claude Nagamine, DVM, PhD, Associate Professor received his D.V.M. from the University of Tennessee in 2004 and completed his residency training in Laboratory Animal Medicine at the Massachusetts Institute of Technology in 2007. He joined the Department of Comparative Medicine at Stanford in 2008.
Prior to entering veterinary school, Dr. Nagamine obtained a Ph.D. in Ecology from the University of California, Davis (1979), obtained postdoctoral training in endocrinology, developmental genetics, immunology, and molecular biology of the mouse at the Memorial Sloan-Kettering Cancer Center (NYC), Institut Pasteur (France), and the Howard Hughes Medical Institute at the University of California, San Francisco and was an Assistant Professor of Cell Biology at the Vanderbilt University School of Medicine. His research focuses on using mouse models to study murine and human infectious diseases. These collaborative studies include dengue virus, adeno-associated virus, coxsackie virus, enterohepatic helicobacters, campylobacters, and anaplasma.
The laboratory mouse is the most widely used mammalian model for biomedical research and comprises over 90% of the non-aquatic, laboratory animals at Stanford. As Director of the Rodent Health Surveillance Program and the Director of Rodent Services, my research and clinical expertise is in mouse reproductive biology, mouse models of mammalian sex determination and sexual differentiation, and mouse models of infectious diseases. Past research focused on the molecular genetics underpinning a mouse model of XY sex reversal and the effect of the bacterial pathogen Helicobacter hepaticus on chemical and genetic models of colon cancer. Current collaborative research is the development of a mouse model for dengue virus to study the relationship between autophagy and dengue virus virulence.
(A) Whole mount of the gastrointestinal tract of a mouse. Asterisks identify dilatations in the small intestine identifying the location of mucosal tumors. st, stomach; si, small intestine; ce, cecum; co, colon. (B) Mucosal surface of one of the dilatations in panel A, showing the presence of large, sessile adenomas (arrows). (C, D) Immunostaining for Β-catenin showing high expression in the adenomas. (Scale bar = 250 mm) (Nagamine et al. Infect Immun. 2008. 76:2758-2766).
Gonads from a hermaphroditic mouse
Histology of a gonad with both testicular (left) and ovarian (right) tissues