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Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma
Not Recruiting
Trial ID: NCT00027846
Purpose
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to
the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in
chemotherapy use different ways to stop tumor cells from dividing so they stop growing or
die. Giving chemotherapy before surgery may shrink the tumor so that it can be removed during
surgery.
PURPOSE: Phase II trial to determine the effectiveness of specialized radiation therapy
either alone or after chemotherapy and second surgery in treating children who have undergone
surgery for localized ependymoma.
Official Title
A Phase II Trial of Conformal Radiation Therapy for Pediatric Patients With Localized Ependymoma, Chemotherapy Prior to Second Surgery for Incompletely Resected Ependymoma and Observation for Completely Resected, Differentiated, Supratentorial Ependymoma
Stanford Investigator(s)
Eligibility
DISEASE CHARACTERISTICS:
- Histologically confirmed intracranial ependymoma
- Differentiated ependymoma or anaplastic ependymoma
- No primary spinal cord ependymoma, myxopapillary ependymoma, subependymoma,
ependymoblastoma, or mixed glioma
- No evidence of noncontiguous spread beyond primary site
- Initial surgical resection within the past 56 days
PATIENT CHARACTERISTICS:
Age:
- 1 to 21
Performance status:
- No restrictions
Life expectancy:
- At least 2 months
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Able to undergo MRI
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Prior or concurrent corticosteroids allowed
Radiotherapy:
- No prior radiotherapy
Surgery:
- See Disease Characteristics
- More than 1 prior surgery allowed
Other:
- No other prior treatment for ependymoma
Intervention(s):
biological: filgrastim
drug: vincristine sulfate
procedure: therapeutic conventional surgery
radiation: radiation therapy
drug: carboplatin
drug: cyclophosphamide
drug: etoposide
drug: Mesna
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Peds Hem/Onc CRAs
650-723-5535