CHRI Faculty Scholars

Gerald Grant, MD, FACS
Arline and Pete Harman Faculty Scholar (2015-2018)
Associate Professor of Neurosurgery and Neurology (by courtesy), Chief of the Pediatric Neurosurgery Division, and Associate Program Director of the Department of Neurosurgery
 
Education:
BS, Duke University, 1989
MD, Stanford University School of Medicine, 1994
Internship and Residency, University of Washington, 2001
Fellowship, Seattle Children’s Hospital, 2002

Research focus:
With his scholarly activity primarily in the field of pediatric brain tumors and epilepsy, Dr. Grant directs a translational research laboratory focusing on the blood-brain barrier (BBB). His current research involves studying the unique differences of the tumor BBB from the normal BBB, as the treatment of pediatric brain tumors in children remains a challenge irrespective of recent improvements. Chemotherapeutic agents for malignant pediatric brain tumors have been particularly inefficient due to the existence of the BBB, which, despite serving primarily as a line of defense against toxic substances entering the brain, hampers the accumulation and uptake of drugs into the tumor. Dr. Grant uses novel, sophisticated techniques to microdissect the blood-brain barrier in tumors and normal brains in order to compare their molecular profile. His work has the potential to translate into the discovery of new targets on brain tumor blood vessels. These proteins could then be targeted to modulate the gate guarding the brain tumor and improve drug delivery and survival.


Matthew Lungren, MD, MPH
Stanford Child Health Research Institute Faculty Scholar (2016-2019)
Assistant Professor of Radiology – Pediatric Radiology

Education:
BA, Arizona State University, 2002
MD, University of Michigan Medical School, 2007
Residency, Duke University, 2012
Fellowship (Adult Interventional Radiology), Duke University, 2013
Fellowship (Pediatric Radiology & Pediatric Interventional Radiology), Cincinnati Children’s Hospital, 2014
MPH, University of North Carolina, Gillings School of Global Public Health, 2014

Research focus:
Dr. Lungren’s research interests include machine learning in imaging outcome prediction and imaging utilization and appropriate use and developing minimally invasive procedures for children, including oncologic and vascular anomaly interventions. Dr. Lungren believes that imaging report narratives can be correlated with clinical data to devise accurate predictive models of medical imaging yield, particularly for diagnosing pulmonary embolism (PE), a condition in which one or more arteries in the lungs become blocked by a blood clot. Given the growing burden and life-long complications of PE, there is an urgent need for guidelines for the surveillance of PE in children. However, an evidence-based diagnostic approach for imaging of PE has not been established in pediatric literature nor has evidence from adult studies been proven applicable for children. Childhood PE risk factors are also shown in small series to be disparate, some overlapping, and not all factors can be accounted for in routine clinical decision making. Dr. Lungren recognizes that the availability of vast clinical electronic medical records (EMR) can provide a treasure trove of point-of-care, relevant, actionable data that can generate practice-based evidence to inform clinical management. In his project, Dr. Lungren will create a predictive model that leverages real-time EMR clinical and laboratory data and prior imaging report data to arrive at a patient-specific imaging prediction, providing pediatricians with the ability to leverage aggregate patient data for improved decision making when treating children.

Mentor: Curtis Langlotz, MD, PhD


Derrick C. Wan, MD
Lucile Packard Foundation for Children’s Health Faculty Scholar (2013-2018)
Assistant Professor of Surgery (Plastic and Reconstructive Surgery)

Education: 
BS, Stanford University, 1997
MD, Columbia University, 2001
Residency, University of California San Francisco – General Surgery, 2007
Residency, University of California Los Angeles, 2009
Fellowship, University of California Los Angeles, 2010
Fellowship, Chang Gung Memorial Hospital, Taiwan, 2011

Research focus:  
Craniofacial skeletal defects following trauma, tumor resection, or due to congenital anomalies in children often present a significant reconstructive challenge.  Limitations in current treatment options have highlighted the need for development of novel approaches for regenerative medicine with the ability to dramatically improve tissue repair.  My research has focused on the use of cell-based strategies to address this need. By understanding fundamental processes guiding bone formation, strategies may one day be developed in which transplanted progenitor cells may be employed to facilitate repair of large bone defects in children.


Virginia D. Winn, MD, PhD
Arline and Pete Harman Faculty Scholar (2015-2018)
Associate Professor of Obstetrics and Gynecology and Director of Perinatal Biology

Education:
BS, Trinity University, 1988
PhD, University of Rochester, 1994
MD, University of Rochester, 1996  
Residency, University of California, San Francisco, 2000
Fellowship, University of California, San Francisco, 2003

Research focus:
Dr. Winn’s primary research focuses on studying the process of human placental development, which is critical for sustaining a pregnancy and supporting the growth and development of a fetus. Studying placental development not only requires understanding the fundamental transport and endocrine functions of the organ, but also entails understanding the physiologic process of immune tolerance, vascular remodeling, and cellular invasion. Understanding both normal and abnormal human placental development is key to understanding placenta-related obstetrical complications such as preeclampsia, intrauterine growth restriction, placenta accreta spectrum disorders, and placenta previa. Dr. Winn’s ultimate goal is to see her discoveries translated into improved health.


Sean M. (Ming) Wu, MD, PhD, FACC
Lucile Packard Foundation for Children’s Health Faculty Scholar (2013-2018)
Assistant Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Pediatrics

Education:
BS, Stanford University, 1992
PhD, Duke University School of Arts and Sciences, 1998
MD, Duke University School of Medicine, 1999
Residency, Duke University Hospital, Internal Medicine, 2001
Fellowship, Massachusetts General Hospital, 2004
Fellowship, Boston Children’s Hospital – Division of Hematology/Oncology/Harvard Medical School, Stem Cell Biology, 2006

Research focus: http://seanwulab.stanford.edu/


Fan Yang, PhD
Lucile Packard Foundation for Children's Health Faculty Scholar (2015-2018)
Mission for Learning Faculty Scholar (2013-2015)
Assistant Professor of Orthopaedic Surgery and of Bioengineering

Education:
BS, Shanghai Jiaotong University, Biomedical Engineering, 2001
PhD, Johns Hopkins University, Biomedical Engineering, 2006

Past Holders

  • Brendan Carvalho, MBBCh, MDCH, FRCA
    Arline and Pete Harman Faculty Scholar (2012-2015)
    Associate Professor of Anesthesiology (Perioperative and Pain)
  • Carol Conrad, MD
    Arline and Pete Harman Faculty Scholar (2011-2014)
    Associate Professor of Pediatrics (Pulmonary Medicine)
  • Ricardo Dolmetsch, PhD
    Barbara and John Packard Faculty Scholar (2011-2014)
    Novartis Institutes for BioMedical Research
  • Sanjeev Dutta, MD, MBA, MA,FRCS(C),FAAP, FACS
    Arline and Pete Harman Faculty Scholar (2009-2012)
    Associate Professor of Surgery (Pediatric Surgery) and of Pediatrics
  • Susan Ruth Hintz, MD, MS, Epi, FAAP
    Arline and Pete Harman Faculty Scholar (2009-2015)
    Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology
  • Deirdre Lyell, MD
    Arline and Pete Harman Faculty Scholar (2011-2014)
    Associate Professor of Obstetrics and Gynecology (Maternal Fetal Medicine)
  • Hsi-Yang Wu, MD
    Arline and Pete Harman Faculty Scholar (2012-2015)
    Associate Professor of Urology