Cancer Biology Program

About Cancer Biology

The Cancer Biology Program is focused on investigating the mechanisms and signaling pathways involved in the development and progression of cancer. The goals are to advance basic understanding of cancer pathogenesis and to facilitate the translation of basic science discoveries into the clinical arena in order to improve the outcomes of patients with cancer.

Program researchers focus on three major scientific themes: 

  • Mechanisms and Pathways of Oncogenesis. Studying the roles of oncogenes and tumor suppressor genes, as well as cell division regulation, genomic stability and DNA damage and repair processes. 
  • Epigenetics. Investigating the causes and impacts of epigenetic (genetic changes caused by external factors) alteration that are increasingly associated with cancer. 
  • Epithelial Neoplasia.  Analyzing the molecular and cellular biology of solid tumors through use of a variety of in vitro and in vivo model systems. 

Program Directors

Lindhard Family Professor in Pediatric Cancer Biology and Professor of Pathology
Maureen Lyles D'Ambrogio Professor and Professor, by courtesy, of Chemical and Systems Biology