Join a Study

Neuroimaging of HIV Infection and Alcoholism

The Neuroimaging of HIV Infection and Alcoholism study has been ongoing for upwards of 15 years. Scientists have learned that the aging brain is highly sensitive to the combined effects of HIV/AIDS, alcoholism, and hepatitis C infection. This study uses longitudinal neuroimaging to identify brain insults underlying the interaction of HIV infection and alcohol abuse with aging and explore how they contribute to the deterioration in clinical, cognitive, and motor abilities in the context of the ultimate frailty of old age. These studies take place at SRI International in Menlo Park.

Who can participate:

  • Men and Women aged 50 – 75 in good health
  • Men and Women aged 50 – 75 recently abstinent from alcohol
  • Men and Women aged 50 – 75 infected with HIV
  • Men and Women aged 50 – 75 recently abstinent from alcohol + HIV infected

Minimal criteria for participation:

  • Completed at least 8 years of education
  • Age-normal corrected hearing and visual acuity
  • No metal implantation (e.g., pacemakers) or other factors that preclude magnetic resonance imaging (MRI) scanning
  • No documented loss of consciousness of over 30 minutes, documented compound skull fracture, or clear neurological sequelae of head trauma
  • No space-occupying lesions detected on clinical reading of MRI
  • No history of medical or neurological illness or trauma potentially affecting the brain, e.g., stroke, multiple sclerosis, epilepsy, psychosurgery, insulin coma, or opportunistic infection
  • No active tuberculosis, active opportunistic infection, or history of any malignancy requiring chemotherapy
  • No history of schizophrenia or bipolar disorder

What participation involves:

  • Typically 2 days in the laboratory, scheduled at your convenience (including weekends)
  • Interviews and questionnaires
  • Computerized and pen and paper tests to evaluate cognition and tests to evaluate motor function
  • Collection of biospecimens (such as blood) for analysis
  • Collection of MRI data for in vivo brain data analysis
  • Potential for follow-up visits with similar activities

Benefits of participating:

  • Contributing to a better understanding of the HIV infected and alcoholic brain.
  • A small stipend for time spent participating.

For more information:

Please contact the study coordinator:

Priya Asok
(650) 859-2585
priya.asok@sri.com
brainaddictionlab@sri.com

This study recruits for NIAAA-funded grant:

Tracking HIV Infection and Alcohol Abuse CNS Comorbidity with Neuroimaging

Neuroimaging of Alcoholism

The Neuroimaging of Alcoholism studies have been ongoing for several decades. Scientists have learned that the marked variability in neuropathology among alcoholics, even with similar consumption histories, is likely due to factors in addition to excessive alcohol consumption, including dietary deficiency, hematopoietic effects, age at exposure, and genetic factors. These studies are aimed at elucidating factors in addition to alcohol per se that contribute to chronic "alcoholic brain damage." These studies take place at SRI International in Menlo Park.

Who can participate:

  • Men and Women aged 40 – 75 in good health
  • Men and Women aged 40 – 75 recently abstinent from alcohol

Minimal criteria for participation:

  • Completed at least 8 years of education
  • Age-normal corrected hearing and visual acuity
  • No metal implantation (e.g., pacemakers) or other factors that preclude magnetic resonance imaging (MRI) scanning
  • No documented loss of consciousness of over 30 minutes, documented compound skull fracture, or clear neurological sequelae of head trauma
  • No space-occupying lesions detected on clinical reading of structural MRI
  • No history of medical or neurological illness or trauma potentially affecting the brain, e.g., stroke, multiple sclerosis, epilepsy, psychosurgery, insulin coma, or opportunistic infection
  • No active tuberculosis, active opportunistic infection, or history of any malignancy requiring chemotherapy
  • No history of schizophrenia or bipolar disorder

What participation involves:

  • Interviews and questionnaires
  • Computerized and pen and paper tests to evaluate cognition and tests to evaluate motor function
  • Collection of biospecimens (such as blood) for analysis
  • Collection of MRI data for in vivo brain data analysis
  • Potential for follow-up visits with similar activities

What are the benefits of participating:

  • Contributing to a better understanding of the alcoholic brain.
  • A small stipend for time spent participating.

For more information:

Please contact the study coordinator:

Priya Asok
(650) 859-2585
priya.asok@sri.com
brainaddictionlab@sri.com

This study recruits for NIAAA-funded grants:

Neuroimaging of HIV and Parkinson’s disease

The Neuroimaging of HIV and Parkinson’s disease study explores similarities and differences in neurocircuitry disrupted in HIV and Parkinson’s disease (PD). The study elucidates the effects of aging on the functional and structural subcortical-cortical brain circuits that subserve cognition and motor functions in individuals with HIV-infection relative to normal aging in healthy participants, and abnormal aging in PD patients.

Who can participate:

  • Men and Women aged 45 – 75 in good health
  • Men and Women aged 45 – 75 infected with HIV
  • Men and Women aged 45 – 75 diagnosed with PD

Where:

This collaborative study will take place at:

  • SRI International Neuroscience Program at the Center for Health Sciences
  • Stanford Neurology, Comprehensive Movement Disorder Center (Brontë-Stewart lab)

Time commitment:

  • HIV and control subjects participate in 1.5 days of testing.
  • PD subjects complete 2.5 days of testing ON and OFF medication.

What participation involves:

  • Interviews and questionnaires
  • Computerized and pen and paper tests to evaluate cognitive and motor function
  • Collection of magnetic resonance imaging (MRI) data for in vivo brain data analysis

Benefits of participating:

  • Contributing to a better understanding of the aging brain
  • A small stipend for time spent participating

For more information:

Individuals with HIV infection and healthy volunteers:

Please contact the study coordinator:

Priya Asok
(650) 859-2585
priya.asok@sri.com
brainaddictionlab@sri.com

Individuals with Parkinson’s disease and healthy volunteers:

Please call the Brontë-Stewart lab:

Phone:           (650) 723-6709

This study recruits for NIAAA-funded grant:

Neurodegeneration and Brain Function in Aging with HIV and Parkinson’s disease