Osteoarthritis (OA) is a major cause of disability - 75% of people over 60 will suffer from OA. In OA, articular cartilage degenerates, leaving no cushion for the joint to articulate, resulting in pain. Acute injuries such as ACL and meniscal tears increase the risk of OA. MRI offers excellent soft tissue contrast, and is the most accurate non-invasive way to image cartilage, menisci, ligaments and tendons.
Our research in OA is directed toward quantitative imaging that can assess OA before symptoms occur. This would be useful to develop, evaluate, and ultimately recommend treatments for OA. We have developed numerous 3D methods for high-resolution acquisition of knee images that can be used to quantitatively map T2, T2*, diffusion and sodium content.
Knee Cartilage MRI T1rho (CubeQuant), T2 (qDESS) and Sodium (Cones) Variability
T1rho and T2 relaxation times as well as sodium MRI are parameters that are correlated with cartilage proteoglycan and collagen macromolecules.
Cluster Analysis for Identifying Focal Cartilage Defects
A new visualization and cluster analysis tool helps identify focal cartilage T2 and T1rho relaxation time defects in the femoral condyles of an ACL-injured population.
Imaging of Metabolic Activity in Osteoarthritis with PET/MRI
Osteoarthritis (OA) is a chronic, degenerative disease of the joint that is characterized by degeneration affecting all tissues in the joint.
Imaging and T2 Relaxometry of Short-T2 Connective Tissues in the Knee using Ultrashort Echo-Time Double-Echo Steady-State (UTEDESS)
Osteoarthritis is a whole-joint disease, however, it is currently challenging to image several tissues in the joint such as the menisci, tendons, and ligaments.
Rapid Volumetric Quantification of Cartilage Biochemistry with MRI
Detection of changes in cartilage glycosaminoglycan (GAG) content and distribution are vital for early diagnosis of osteoarthritis (OA) and potential treatment monitoring.
Estimation of Multiple Tissue Parameters Using the DESS Sequence
The Double-Echo Steady-State (DESS) sequence, which produces undistorted, SNR-efficient 3D scans, can provide estimates of multiple tissue parameters.
A Simple Analytic Method for Estimating T2 in the Knee from DESS
MRI measurements of the relaxation time T2 can help estimate the progression of diseases such as osteoarthritis and its associated tissue deterioration. The Double-Echo Steady-State (DESS) sequence is often used for radiographic images of the knee.
Five-Minute Knee MRI for Simultaneous Morphometry and T2 Relaxometry Using DESS
We have developed a method for knee MRI that can acquire MRI-based biomarkers in a single 5-minute scan.
Simultaneous Bilateral Knee MR Imaging
Osteoarthritis (OA) remains a tremendous burden to society, affecting the majority of the population by age 65.
MRI of Peripheral Nerves
This work enables high-resolution depiction of nerve fascicular structure - evaluation of such structure can be useful in diagnosing subtle nerve damage.