Osteoarthritis (OA) is a major cause of disability - 75% of people over 60 will suffer from OA. In OA, articular cartilage degenerates, leaving no cushion for the joint to articulate, resulting in pain. Acute injuries such as ACL and meniscal tears increase the risk of OA. MRI offers excellent soft tissue contrast, and is the most accurate non-invasive way to image cartilage, menisci, ligaments and tendons.
Our research in OA is directed toward quantitative imaging that can assess OA before symptoms occur. This would be useful to develop, evaluate, and ultimately recommend treatments for OA. We have developed numerous 3D methods for high-resolution acquisition of knee images that can be used to quantitatively map T2, T2*, diffusion and sodium content.
Super-Resolution Musculoskeletal MRI Using Deep Learning
In this manuscript, we have demonstrated a method termed ‘DeepResolve’, which can transform low-resolution magnetic resonance images (MRI) into higher-resolution images.
Simultaneous Bilateral Knee MR Imaging
Osteoarthritis (OA) remains a tremendous burden to society, affecting the majority of the population by age 65.
MRI of Peripheral Nerves
This work enables high-resolution depiction of nerve fascicular structure - evaluation of such structure can be useful in diagnosing subtle nerve damage.
Five-Minute Knee MRI for Simultaneous Morphometry and T2 Relaxometry Using DESS
We have developed a method for knee MRI that can acquire MRI-based biomarkers in a single 5-minute scan.
Imaging and T2 Relaxometry of Short-T2 Connective Tissues in the Knee using UTEDESS
Osteoarthritis is a whole-joint disease, but it is currently challenging to image some of the tissues in the knee.
Imaging of Metabolic Activity in Osteoarthritis with PET/MRI
Osteoarthritis (OA) is a chronic, degenerative disease of the joint that is characterized by degeneration affecting all tissues in the joint.
Cluster Analysis for Identifying Focal Cartilage Defects
A new visualization and cluster analysis tool helps identify focal cartilage T2 and T1rho relaxation time defects in the femoral condyles of an ACL-injured population.
Rapid Volumetric Quantification of Cartilage Biochemistry with MRI
Detection of changes in cartilage glycosaminoglycan (GAG) content and distribution are vital for early diagnosis of osteoarthritis (OA) and potential treatment monitoring.
Knee Cartilage MRI T1rho (CubeQuant), T2 (qDESS) and Sodium (Cones) Variability
T1rho and T2 relaxation times as well as sodium MRI are parameters that are correlated with cartilage proteoglycan and collagen macromolecules.
Estimation of Multiple Tissue Parameters Using the DESS Sequence
The Double-Echo Steady-State (DESS) sequence, which produces undistorted, SNR-efficient 3D scans, can provide estimates of multiple tissue parameters.