MRI of Peripheral Nerves

Evaluation of the nerve fascicular structure can be useful in diagnosing subtle nerve damage. Ultra-high-resolution MRI with in-plane resolution of about 100um has the potential to improve the visualization of nerve fascicles. However, it is a very challenging task with 3T MRI due to resolution limit imposed by its available signal-to-noise ratio. 7T MRI has the potential for higher resolution than 3T MRI due to the signal boost with higher proton polarization. Our comparison study demonstrated much sharper delineation of nerve fascicular structures can be obtained at 7T MRI than at 3T MRI.

Yoon D, Biswal S, Rutt B, Lutz A, Hargreaves B. Feasibility of 7T MRI for imaging fascicular structures of peripheral nerves. Muscle Nerve. 2017 Dec 6. doi: 10.1002/mus.26035.

Online Journal Article

The fascicles of the tibial nerve at high resolution (0.13mm) images acquired at 3T and 7T. Tibial nerve fascicles are enclosed in a dotted line in (C) and (D), and they are more sharply presented at 7T than 3T. Also, the perineurium (the bright rim of each fascicle) is more easily identified at 7T than 3T.

Physical Sci Res Assoc, Rad/Radiological Sciences Laboratory
Associate Professor of Radiology (General Radiology) at the Stanford University Medical Center
Professor of Radiology (General Radiology)
(650) 721-6230
Assistant Professor of Radiology (Musculoskeletal Imaging) at the Stanford University Medical Center
Associate Professor of Radiology (Radiological Sciences Laboratory) and, by courtesy, of Electrical Engineering and of Bioengineering
(650) 498-5368

Brian Hargreaves PhD

Associate Professor of Radiology, and (by courtesy) Electrical Engineering and Bioengineering

Contact Information

Lucas Center for Imaging 
1201 Welch Rd, Stanford, CA 94305-5488

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