Imaging and T2 Relaxometry of Short-T2 Connective Tissues in the Knee using Ultrashort Echo-Time Double-Echo Steady-State (UTEDESS)

Osteoarthritis is a whole-joint disease, however, it is currently challenging to image several tissues in the joint such as the menisci, tendons, and ligaments. This is because such tissues have short-T2 relaxation times which means that they lose energy rapidly following a radiofrequency excitation. More recently, there has been compelling evidence suggesting that measuring the T2 of tissues may be beneficial in assessing their biochemical integrity. Thus, in this study, we propose a new method, termed Ultrashort Echo-Time Double-Echo Steady-State (UTEDESS) which utilizes a 3D-radial k-space acquisition scheme instead of traditional Cartesian sampling. UTEDESS allows imaging and quantification of the T2 of the meniscus, tendons, and ligaments while also providing a retrospective water/far separation as well as images with high-isotropic resolution. This new method is promising for quantitative MRI of the whole knee and may be useful in detecting new biomarkers of osteoarthritis activity.

Chaudhari AS, Sveinsson B, Moran CJ, McWalter EJ, Johnson EM, Zhang T, Gold GE, Hargreaves BA. Imaging and T2 Relaxometry of Short-T2 Connective Tissues in the Knee using Ultrashort Echo-Time Double-Echo Steady-State (UTEDESS). Magn Reson Med. 2017 Jan 11. doi:10.1002/mrm.26577.

Online Journal Article

Panels a-f indicate the different contrasts that can be obtained with UTEDESS while panels g-i show how T2 mapping can be performed for short-T2 tissues in arbitrary scan planes.

Postdoctoral Research Fellow, Radiological Sciences Laboratory
Physical Sci Res Assoc, Rad/Radiological Sciences Laboratory
Professor of Radiology (General Radiology)
(650) 724-0361
Associate Professor of Radiology (Radiological Sciences Laboratory) and, by courtesy, of Electrical Engineering and of Bioengineering
(650) 498-5368

Bragi Sveinsson and Emily McWalter are alumni of the BMR group

Brian Hargreaves PhD

Associate Professor of Radiology, and (by courtesy) Electrical Engineering and Bioengineering

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