Cluster Analysis for Identifying Focal Cartilage Defects

A new visualization and cluster analysis tool helps identify focal cartilage T2 and T1rho relaxation time defects in the femoral condyles of an ACL-injured population. Focal defects in cartilage are an important pathological change in Osteoarthritis that has received relatively little attention in the quantitative cartilage MRI literature. We first created projection maps of the 3D cartilage surface within the femoral condyles using a best-fit cylinder to the cartilage-bone interface and radial bins of 1o increments. We then used intensity and area thresholds from cartilage quantitative changes within a healthy population, to identify elevated T2 and T1rho relaxation times over a 1-year follow up period of an ACL-injured population. This proposed tool shows promise for better detecting and tracking early degenerative changes. It may also be used for understanding the cartilage degenerative process and effectively evaluating and monitoring therapeutic approaches for OA. 

Monu UD, Jordan CD, Samuelson BL, Hargreaves BA, Gold GE, McWalter EJ.   Cluster Analysis of Quantitative MRI T2 and T1ρ Relaxation Times of Cartilage Identifies Differences between Healthy and ACL-injured Individuals. Osteoarthritis and Cartilage 2016 Oct 5. doi: 10.1016/j.joca.2016.09.015.

Online Journal Article

Cluster Maps within ACL-Injured Patients over time

Professor of Radiology (Radiological Sciences Laboratory) and, by courtesy, of Electrical Engineering
(650) 498-5368
Professor of Radiology (Musculoskeletal Imaging)
(650) 724-0361

Caroline Jordan and Emily McWalter are alumni of the BMR group

Contact Information

Lucas Center for Imaging 
1201 Welch Rd, Stanford, CA 94305-5488

Directions: Lucas Ctr. or Porter Dr. Locations